PAX8 [The Human Chemical-Genetic Interaction Map Project]

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======= PAX8 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PAX8
  * **<color #00a2e8>Official Name</color>**: paired box 8
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7849|7849]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q06710|Q06710]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PAX8&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PAX8|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/167415|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the paired box (PAX) family of transcription factors. Members of this gene family typically encode proteins that contain a paired box domain, an octapeptide, and a paired-type homeodomain. This nuclear protein is involved in thyroid follicular cell development and expression of thyroid-specific genes. Mutations in this gene have been associated with thyroid dysgenesis, thyroid follicular carcinomas and atypical follicular thyroid adenomas. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Mar 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Transcription factor for the thyroid-specific expression of the genes exclusively expressed in the thyroid cell type, maintaining the functional differentiation of such cells.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PAX|
|Pax2 C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of thyroid-stimulating hormone secretion|
|positive regulation of metanephric DCT cell differentiation|
|negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis|
|thyroid-stimulating hormone receptor activity|
|thyroid-stimulating hormone signaling pathway|
|regulation of metanephric DCT cell differentiation|
|regulation of apoptotic process involved in metanephric nephron tubule development|
|pronephric field specification|
|negative regulation of apoptotic process involved in metanephric nephron tubule development|
|negative regulation of apoptotic process involved in metanephric collecting duct development|
|regulation of apoptotic process involved in metanephric collecting duct development|
|pattern specification involved in pronephros development|
|kidney field specification|
|regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis|
|regulation of mesenchymal cell apoptotic process involved in metanephros development|
|metanephric comma-shaped body morphogenesis|
|positive regulation of thyroid hormone generation|
|kidney rudiment formation|
|negative regulation of mesenchymal cell apoptotic process involved in metanephros development|
|regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis|
|positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis|
|negative regulation of somatic stem cell population maintenance|
|negative regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis|
|metanephric nephron tubule formation|
|regulation of thyroid hormone generation|
|comma-shaped body morphogenesis|
|metanephric distal convoluted tubule development|
|distal convoluted tubule development|
|metanephric S-shaped body morphogenesis|
|negative regulation of apoptotic process involved in morphogenesis|
|negative regulation of apoptotic process involved in development|
|metanephric tubule formation|
|regulation of somatic stem cell population maintenance|
|negative regulation of stem cell population maintenance|
|S-shaped body morphogenesis|
|mesenchymal to epithelial transition involved in metanephros morphogenesis|
|regulation of metanephric nephron tubule epithelial cell differentiation|
|metanephric distal tubule development|
|positive regulation of epithelial cell differentiation involved in kidney development|
|metanephric nephron tubule morphogenesis|
|regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis|
|pronephros development|
|renal system pattern specification|
|pattern specification involved in kidney development|
|negative regulation of metanephros development|
|negative regulation of mesenchymal cell apoptotic process|
|metanephric renal vesicle morphogenesis|
|metanephric tubule morphogenesis|
|regulation of apoptotic process involved in development|
|distal tubule development|
|regulation of apoptotic process involved in morphogenesis|
|renal vesicle morphogenesis|
|regulation of mesenchymal cell apoptotic process|
|regulation of nephron tubule epithelial cell differentiation|
|renal vesicle development|
|otic vesicle development|
|positive regulation of metanephros development|
|metanephric nephron tubule development|
|mesenchymal to epithelial transition|
|positive regulation of hormone metabolic process|
|specification of animal organ identity|
|negative regulation of kidney development|
|metanephric nephron epithelium development|
|nephron tubule formation|
|cell differentiation involved in metanephros development|
|cellular response to gonadotropin stimulus|
|metanephric tubule development|
|positive regulation of branching involved in ureteric bud morphogenesis|
|regulation of epithelial cell differentiation involved in kidney development|
|metanephric nephron morphogenesis|
|positive regulation of mesonephros development|
|metanephric epithelium development|
|thyroid gland development|
|negative regulation of cardiac muscle cell apoptotic process|
|regulation of branching involved in ureteric bud morphogenesis|
|regulation of metanephros development|
|negative regulation of striated muscle cell apoptotic process|
|regulation of mesonephros development|
|metanephros morphogenesis|
|regulation of stem cell population maintenance|
|response to gonadotropin|
|epithelial cell differentiation involved in kidney development|
|metanephric nephron development|
|negative regulation of animal organ morphogenesis|
|positive regulation of morphogenesis of an epithelium|
|animal organ formation|
|negative regulation of muscle cell apoptotic process|
|regulation of cardiac muscle cell apoptotic process|
|regulation of hormone metabolic process|
|regulation of striated muscle cell apoptotic process|
|positive regulation of kidney development|
|cell differentiation involved in kidney development|
|branching involved in ureteric bud morphogenesis|
|ureteric bud morphogenesis|
|mesonephric tubule morphogenesis|
|regulation of kidney development|
|regulation of morphogenesis of a branching structure|
|positive regulation of epithelial cell differentiation|
|nephron tubule morphogenesis|
|nephron epithelium morphogenesis|
|nephron morphogenesis|
|regulation of muscle cell apoptotic process|
|renal tubule morphogenesis|
|ventricular septum development|
|nephron tubule development|
|renal tubule development|
|positive regulation of animal organ morphogenesis|
|metanephros development|
|kidney morphogenesis|
|ureteric bud development|
|mesonephric tubule development|
|mesonephric epithelium development|
|mesonephros development|
|nephron epithelium development|
|inner ear morphogenesis|
|cardiac septum development|
|ear morphogenesis|
|endocrine system development|
|embryonic epithelial tube formation|
|nephron development|
|cardiac ventricle development|
|kidney epithelium development|
|branching morphogenesis of an epithelial tube|
|epithelial tube formation|
|regulation of epithelial cell differentiation|
|morphogenesis of embryonic epithelium|
|tube formation|
|morphogenesis of a branching epithelium|
|morphogenesis of a branching structure|
|cardiac chamber development|
|regulation of morphogenesis of an epithelium|
|inner ear development|
|regulation of peptide hormone secretion|
|transcription regulatory region DNA binding|
|ear development|
|sensory organ morphogenesis|
|regulation of animal organ morphogenesis|
|regulation of hormone secretion|
|kidney development|
|renal system development|
|embryonic organ morphogenesis|
|epithelial tube morphogenesis|
|urogenital system development|
|regionalization|
|sulfur compound metabolic process|
|gland development|
|morphogenesis of an epithelium|
|embryonic organ development|
|pattern specification process|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|regulation of peptide secretion|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|heart development|
|regulation of hormone levels|
|sensory organ development|
|tissue morphogenesis|
|embryonic morphogenesis|
|cellular response to hormone stimulus|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|tube morphogenesis|
|DNA-binding transcription factor activity|
|epithelial cell differentiation|
|regulation of peptide transport|
|regulation of secretion by cell|
|regulation of secretion|
|tube development|
|circulatory system development|
|negative regulation of apoptotic process|
|anatomical structure formation involved in morphogenesis|
|negative regulation of programmed cell death|
|response to hormone|
|negative regulation of developmental process|
|animal organ morphogenesis|
|positive regulation of cell differentiation|
|embryo development|
|central nervous system development|
|negative regulation of cell death|
|regulation of anatomical structure morphogenesis|
|nucleobase-containing compound biosynthetic process|
|epithelium development|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|negative regulation of multicellular organismal process|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|organic cyclic compound biosynthetic process|
|G protein-coupled receptor signaling pathway|
|positive regulation of developmental process|
|DNA binding|
|response to endogenous stimulus|
|positive regulation of transcription, DNA-templated|
|regulation of apoptotic process|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of programmed cell death|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|RNA metabolic process|
|regulation of cell death|
|cellular macromolecule biosynthetic process|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|macromolecule biosynthetic process|
|regulation of cell differentiation|
|regulation of transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp46|HMS-I1 1μM R01 exp46]]|2.26|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.453|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 27/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|8/21|
|liver|1/20|
|lung|1/75|
|lymphocyte|0/16|
|ovary|8/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|1/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|3/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9895
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.36 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PAX8 Expression in NALM6 Cells: 2.36'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>