PBXIP1 [The Human Chemical-Genetic Interaction Map Project]

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======= PBXIP1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PBXIP1
  * **<color #00a2e8>Official Name</color>**: PBX homeobox interacting protein 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=57326|57326]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96AQ6|Q96AQ6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PBXIP1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PBXIP1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/618819|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Regulator of pre-B-cell leukemia transcription factors (BPXs) function. Inhibits the binding of PBX1-HOX complex to DNA and blocks the transcriptional activity of E2A-PBX1. Tethers estrogen receptor-alpha (ESR1) to microtubules and allows them to influence estrogen receptors-alpha signaling. {ECO:0000269|PubMed:10825160, ECO:0000269|PubMed:12360403, ECO:0000269|PubMed:17043237}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|transcription corepressor activity|
|microtubule|
|negative regulation of transcription, DNA-templated|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|negative regulation of gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|-2.12|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|-2.07|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|-2.06|
|[[:results:exp532|TIC10 10μM R08 exp532]]|-1.94|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|-1.85|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|-1.83|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|-1.8|
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|-1.71|
|[[:results:exp141|Nifurtimox 1μM R03 exp141]]|1.81|
|[[:results:exp78|Pterostilbene 16μM R02 exp78]]|1.86|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:twistnb|TWISTNB]]|0.482|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.479|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.475|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.466|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.464|
|[[:human genes:r:rps7|RPS7]]|0.458|
|[[:human genes:c:chd4|CHD4]]|0.456|
|[[:human genes:c:chmp2a|CHMP2A]]|0.455|
|[[:human genes:t:tp53tg3|TP53TG3]]|0.455|
|[[:human genes:t:tp53tg3b|TP53TG3B]]|0.455|
|[[:human genes:t:tp53tg3c|TP53TG3C]]|0.454|
|[[:human genes:p:psma6|PSMA6]]|0.453|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.451|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.451|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.451|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.45|
|[[:human genes:c:col2a1|COL2A1]]|0.443|
|[[:human genes:n:nol10|NOL10]]|0.443|
|[[:human genes:d:ddtl|DDTL]]|0.441|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.44|
|[[:human genes:s:supt5h|SUPT5H]]|0.44|
|[[:human genes:m:med17|MED17]]|0.433|
|[[:human genes:s:stil|STIL]]|0.431|
|[[:human genes:v:vasn|VASN]]|0.431|
|[[:human genes:p:pwp2|PWP2]]|0.43|
|[[:human genes:d:dnttip2|DNTTIP2]]|0.43|
|[[:human genes:t:timeless|TIMELESS]]|0.428|
|[[:human genes:c:cbwd3|CBWD3]]|0.425|
|[[:human genes:p:polr2j3|POLR2J3]]|0.423|
|[[:human genes:p:prim1|PRIM1]]|0.423|
|[[:human genes:s:supt6h|SUPT6H]]|0.422|
|[[:human genes:l:lrr1|LRR1]]|0.422|
|[[:human genes:s:slc6a17|SLC6A17]]|0.419|
|[[:human genes:d:ddx56|DDX56]]|0.419|
|[[:human genes:n:npipb8|NPIPB8]]|0.419|
|[[:human genes:r:rad51|RAD51]]|0.418|
|[[:human genes:c:c14orf93|C14orf93]]|0.414|
|[[:human genes:r:rrp15|RRP15]]|0.412|
|[[:human genes:l:lad1|LAD1]]|0.412|
|[[:human genes:u:upf1|UPF1]]|0.412|
|[[:human genes:s:slc38a7|SLC38A7]]|0.41|
|[[:human genes:p:psmd2|PSMD2]]|0.409|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.409|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.409|
|[[:human genes:p:pan2|PAN2]]|0.408|
|[[:human genes:m:myb|MYB]]|0.407|
|[[:human genes:c:cbwd5|CBWD5]]|0.406|
|[[:human genes:s:slc4a1|SLC4A1]]|0.405|
|[[:human genes:p:psmb2|PSMB2]]|0.405|
|[[:human genes:o:ogfr|OGFR]]|0.404|
|[[:human genes:t:tp53tg3d|TP53TG3D]]|0.403|
|[[:human genes:d:dtl|DTL]]|0.402|
|[[:human genes:c:cope|COPE]]|0.401|
|[[:human genes:m:myo18a|MYO18A]]|0.401|
|[[:human genes:m:mfrp|MFRP]]|0.401|
|[[:human genes:p:psmd3|PSMD3]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2130
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.01 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PBXIP1 Expression in NALM6 Cells: 6.01'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>