PCCA [The Human Chemical-Genetic Interaction Map Project]

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======= PCCA =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PCCA
  * **<color #00a2e8>Official Name</color>**: propionyl-CoA carboxylase subunit alpha
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5095|5095]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P05165|P05165]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PCCA&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PCCA|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/232000|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is the alpha subunit of the heterodimeric mitochondrial enzyme Propionyl-CoA carboxylase. PCCA encodes the biotin-binding region of this enzyme. Mutations in either PCCA or PCCB (encoding the beta subunit) lead to an enzyme deficiency resulting in propionic acidemia. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Biotin carb C|
|RimK|
|Dala Dala lig C|
|Biotin lipoyl|
|CPSase L D2|
|ATP-grasp|
|CPSase L chain|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|propionyl-CoA carboxylase activity|
|biotin binding|
|short-chain fatty acid catabolic process|
|biotin metabolic process|
|short-chain fatty acid metabolic process|
|water-soluble vitamin metabolic process|
|fatty acid catabolic process|
|monocarboxylic acid catabolic process|
|vitamin metabolic process|
|cellular lipid catabolic process|
|coenzyme metabolic process|
|carboxylic acid catabolic process|
|organic acid catabolic process|
|lipid catabolic process|
|fatty acid metabolic process|
|enzyme binding|
|sulfur compound metabolic process|
|mitochondrial matrix|
|small molecule catabolic process|
|cofactor metabolic process|
|drug metabolic process|
|monocarboxylic acid metabolic process|
|cellular amide metabolic process|
|carboxylic acid metabolic process|
|cellular lipid metabolic process|
|oxoacid metabolic process|
|organic acid metabolic process|
|lipid metabolic process|
|ATP binding|
|small molecule metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|-1.82|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|-1.82|
|[[:results:exp145|PNU96415E 10μM R03 exp145]]|2.02|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:prim1|PRIM1]]|0.435|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6327
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.42 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PCCA Expression in NALM6 Cells: 3.42'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>