PCDHB12 [The Human Chemical-Genetic Interaction Map Project]

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======= PCDHB12 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: N/A
  * **<color #00a2e8>Official Name</color>**: N/A
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: N/A
  * **<color #00a2e8>UniProt</color>**: N/A
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PCDHB12&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PCDHB12|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: N/A

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Cadherin 2|
|Cadherin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|homophilic cell adhesion via plasma membrane adhesion molecules|
|cell-cell adhesion via plasma-membrane adhesion molecules|
|cell-cell adhesion|
|calcium ion binding|
|cell adhesion|
|biological adhesion|
|integral component of plasma membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp191|Hypoxia 5%O2 R04 exp191]]|-2.07|
|[[:results:exp133|MKC9989 10μM R03 exp133]]|-1.98|
|[[:results:exp279|D-Fructose 10000μM R06 exp279]]|-1.94|
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|-1.84|
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|-1.77|
|[[:results:exp432|YM155 0.001μM R08 exp432]]|-1.74|
|[[:results:exp4|Actinomycin-D 0.01μM R00 exp4]]|-1.72|
|[[:results:exp54|Taxol 0.002μM R01 exp54]]|1.77|
|[[:results:exp8|Brefeldin A 0.02μM R00 exp8]]|1.79|
|[[:results:exp112|S-DABN 8μM R03 exp112]]|1.84|
|[[:results:exp537|WNT3A 44ng/ml R08 exp537]]|1.89|
|[[:results:exp40|2-Methoxyestradiol 0.2μM R01 exp40]]|2.06|
|[[:results:exp426|FBS-Wisent 0.1 R07 exp426]]|2.06|
|[[:results:exp425|Beta-Estradiol 0.55μM R07 exp425]]|2.12|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: N/A
^Tissue^Fraction Of Cell Lines Where Essential^
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18122
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -2.08 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PCDHB12 Expression in NALM6 Cells: -2.08'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>