PCF11 [The Human Chemical-Genetic Interaction Map Project]

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======= PCF11 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PCF11
  * **<color #00a2e8>Official Name</color>**: PCF11 cleavage and polyadenylation factor subunit
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51585|51585]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O94913|O94913]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PCF11&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PCF11|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608876|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene binds to CLP1 to form pre-mRNA cleavage factor IIm. The encoded protein is necessary for efficient Pol II transcription termination and may be involved in degradation of the 3' product of polyA site cleavage. [provided by RefSeq, Oct 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Component of pre-mRNA cleavage complex II.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mRNA cleavage factor complex|
|mRNA cleavage|
|mRNA polyadenylation|
|RNA polyadenylation|
|RNA polymerase II complex binding|
|termination of RNA polymerase II transcription|
|DNA-templated transcription, termination|
|mRNA 3-end processing|
|RNA 3-end processing|
|RNA phosphodiester bond hydrolysis|
|mRNA binding|
|RNA splicing, via transesterification reactions with bulged adenosine as nucleophile|
|mRNA splicing, via spliceosome|
|nucleic acid phosphodiester bond hydrolysis|
|RNA splicing, via transesterification reactions|
|RNA splicing|
|mRNA processing|
|transcription by RNA polymerase II|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|mRNA metabolic process|
|RNA processing|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|mitochondrion|
|organic cyclic compound biosynthetic process|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp414|Tozasertib 0.1μM R07 exp414]]|-1.86|
|[[:results:exp521|Salinomycin 3.5μM R08 exp521]]|-1.82|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|-1.71|
|[[:results:exp298|Sucrose 20000μM R06 exp298]]|1.87|
|[[:results:exp52|Ribavirin 10μM R01 exp52]]|1.91|
|[[:results:exp42|BI-6727 0.001μM R01 exp42]]|2.06|
|[[:results:exp225|Celastrol 0.12μM R05 exp225]]|2.11|
|[[:results:exp185|L-BMAA 500 to 750μM on day4 R04 exp185]]|2.13|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.55|
|[[:human genes:o:orc1|ORC1]]|0.528|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.523|
|[[:human genes:s:supt6h|SUPT6H]]|0.523|
|[[:human genes:s:scaf1|SCAF1]]|0.519|
|[[:human genes:c:cbwd3|CBWD3]]|0.516|
|[[:human genes:f:fbxw9|FBXW9]]|0.514|
|[[:human genes:n:npipb5|NPIPB5]]|0.512|
|[[:human genes:r:rps12|RPS12]]|0.511|
|[[:human genes:c:cbwd5|CBWD5]]|0.503|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.501|
|[[:human genes:d:ddtl|DDTL]]|0.498|
|[[:human genes:t:tceb3c|TCEB3C]]|0.494|
|[[:human genes:d:disp2|DISP2]]|0.49|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.488|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.487|
|[[:human genes:o:orc6|ORC6]]|0.487|
|[[:human genes:h:hmgcr|HMGCR]]|0.487|
|[[:human genes:t:tfip11|TFIP11]]|0.481|
|[[:human genes:o:ogfr|OGFR]]|0.48|
|[[:human genes:r:ranbp2|RANBP2]]|0.479|
|[[:human genes:p:pola2|POLA2]]|0.479|
|[[:human genes:r:rps2|RPS2]]|0.477|
|[[:human genes:n:nupl1|NUPL1]]|0.475|
|[[:human genes:t:twistnb|TWISTNB]]|0.471|
|[[:human genes:b:bysl|BYSL]]|0.47|
|[[:human genes:n:nbpf10|NBPF10]]|0.469|
|[[:human genes:p:psmd11|PSMD11]]|0.467|
|[[:human genes:w:wdr43|WDR43]]|0.467|
|[[:human genes:g:gga3|GGA3]]|0.465|
|[[:human genes:c:chd4|CHD4]]|0.465|
|[[:human genes:n:nol12|NOL12]]|0.464|
|[[:human genes:n:nop16|NOP16]]|0.463|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.463|
|[[:human genes:r:rffl|RFFL]]|0.461|
|[[:human genes:r:rpl14|RPL14]]|0.459|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.457|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.455|
|[[:human genes:p:psma6|PSMA6]]|0.454|
|[[:human genes:r:rad51|RAD51]]|0.453|
|[[:human genes:m:med29|MED29]]|0.452|
|[[:human genes:t:tspy8|TSPY8]]|0.451|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.45|
|[[:human genes:c:cdc6|CDC6]]|0.45|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.45|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.45|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.45|
|[[:human genes:m:med17|MED17]]|0.449|
|[[:human genes:s:ssh2|SSH2]]|0.449|
|[[:human genes:p:plk4|PLK4]]|0.448|
|[[:human genes:t:ticrr|TICRR]]|0.447|
|[[:human genes:c:ccdc94|CCDC94]]|0.447|
|[[:human genes:l:lrr1|LRR1]]|0.447|
|[[:human genes:s:srrm2|SRRM2]]|0.446|
|[[:human genes:n:nol10|NOL10]]|0.445|
|[[:human genes:d:dtl|DTL]]|0.445|
|[[:human genes:p:pan3|PAN3]]|0.444|
|[[:human genes:i:ik|IK]]|0.444|
|[[:human genes:k:kctd17|KCTD17]]|0.443|
|[[:human genes:c:c14orf93|C14orf93]]|0.443|
|[[:human genes:c:copa|COPA]]|0.443|
|[[:human genes:n:nup205|NUP205]]|0.442|
|[[:human genes:t:traip|TRAIP]]|0.442|
|[[:human genes:h:hivep3|HIVEP3]]|0.441|
|[[:human genes:c:cbwd6|CBWD6]]|0.44|
|[[:human genes:r:rpl35|RPL35]]|0.44|
|[[:human genes:i:igfn1|IGFN1]]|0.44|
|[[:human genes:h:hinfp|HINFP]]|0.439|
|[[:human genes:r:rad21|RAD21]]|0.437|
|[[:human genes:z:zfand5|ZFAND5]]|0.437|
|[[:human genes:p:psmb4|PSMB4]]|0.436|
|[[:human genes:s:sfpq|SFPQ]]|0.435|
|[[:human genes:m:mt1e|MT1E]]|0.435|
|[[:human genes:g:golga6l1|GOLGA6L1]]|0.434|
|[[:human genes:t:tsr1|TSR1]]|0.433|
|[[:human genes:v:vasn|VASN]]|0.432|
|[[:human genes:a:aqr|AQR]]|0.432|
|[[:human genes:r:riok2|RIOK2]]|0.431|
|[[:human genes:t:timeless|TIMELESS]]|0.431|
|[[:human genes:s:smg1|SMG1]]|0.43|
|[[:human genes:t:top1mt|TOP1MT]]|0.429|
|[[:human genes:t:terf1|TERF1]]|0.429|
|[[:human genes:r:rps9|RPS9]]|0.428|
|[[:human genes:s:sult2b1|SULT2B1]]|0.425|
|[[:human genes:r:rpl6|RPL6]]|0.425|
|[[:human genes:r:rps3a|RPS3A]]|0.424|
|[[:human genes:h:hist1h3i|HIST1H3I]]|0.424|
|[[:human genes:p:pan2|PAN2]]|0.423|
|[[:human genes:z:znf655|ZNF655]]|0.423|
|[[:human genes:h:hnrnpa1|HNRNPA1]]|0.423|
|[[:human genes:s:supt5h|SUPT5H]]|0.421|
|[[:human genes:p:paf1|PAF1]]|0.421|
|[[:human genes:a:ankle1|ANKLE1]]|0.419|
|[[:human genes:i:iscu|ISCU]]|0.419|
|[[:human genes:d:dido1|DIDO1]]|0.418|
|[[:human genes:z:znf830|ZNF830]]|0.418|
|[[:human genes:s:s1pr4|S1PR4]]|0.418|
|[[:human genes:m:micu2|MICU2]]|0.417|
|[[:human genes:r:rpl38|RPL38]]|0.417|
|[[:human genes:m:myo1h|MYO1H]]|0.416|
|[[:human genes:r:rpl34|RPL34]]|0.416|
|[[:human genes:m:madcam1|MADCAM1]]|0.416|
|[[:human genes:p:psmc6|PSMC6]]|0.416|
|[[:human genes:s:slc6a17|SLC6A17]]|0.414|
|[[:human genes:c:cactin|CACTIN]]|0.414|
|[[:human genes:e:elmod3|ELMOD3]]|0.414|
|[[:human genes:r:rps14|RPS14]]|0.414|
|[[:human genes:p:prim1|PRIM1]]|0.414|
|[[:human genes:a:ankle2|ANKLE2]]|0.414|
|[[:human genes:r:rps19bp1|RPS19BP1]]|0.414|
|[[:human genes:f:fbxo5|FBXO5]]|0.412|
|[[:human genes:g:gprin2|GPRIN2]]|0.409|
|[[:human genes:o:or10g3|OR10G3]]|0.409|
|[[:human genes:h:hist1h2be|HIST1H2BE]]|0.408|
|[[:human genes:c:ccna2|CCNA2]]|0.408|
|[[:human genes:c:cdt1|CDT1]]|0.407|
|[[:human genes:g:gosr2|GOSR2]]|0.407|
|[[:human genes:s:sf3a3|SF3A3]]|0.407|
|[[:human genes:z:znf541|ZNF541]]|0.407|
|[[:human genes:t:terf2|TERF2]]|0.405|
|[[:human genes:s:slc4a1|SLC4A1]]|0.404|
|[[:human genes:t:topbp1|TOPBP1]]|0.404|
|[[:human genes:a:akirin2|AKIRIN2]]|0.404|
|[[:human genes:m:med14|MED14]]|0.403|
|[[:human genes:c:cdc45|CDC45]]|0.402|
|[[:human genes:c:copb2|COPB2]]|0.402|
|[[:human genes:c:cep192|CEP192]]|0.402|
|[[:human genes:e:exd1|EXD1]]|0.4|
|[[:human genes:a:atp6v0b|ATP6V0B]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 615/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|23/28|
|blood|25/28|
|bone|25/25|
|breast|30/33|
|central nervous system|47/56|
|cervix|2/4|
|colorectal|15/17|
|esophagus|11/13|
|fibroblast|1/1|
|gastric|10/15|
|kidney|18/21|
|liver|16/20|
|lung|67/75|
|lymphocyte|13/14|
|ovary|21/26|
|pancreas|19/24|
|peripheral nervous system|16/16|
|plasma cell|12/15|
|prostate|1/1|
|skin|21/24|
|soft tissue|7/7|
|thyroid|2/2|
|upper aerodigestive|16/22|
|urinary tract|22/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 706
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.43 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PCF11 Expression in NALM6 Cells: 7.43'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>