PCSK1 [The Human Chemical-Genetic Interaction Map Project]

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======= PCSK1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PCSK1
  * **<color #00a2e8>Official Name</color>**: proprotein convertase subtilisin/kexin type 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5122|5122]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P29120|P29120]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PCSK1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PCSK1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/162150|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER and sorts to subcellular compartments where a second autocatalytic even takes place and the catalytic activity is acquired. The protease is packaged into and activated in dense core secretory granules and expressed in the neuroendocrine system and brain. This gene encodes one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. It functions in the proteolytic activation of polypeptide hormones and neuropeptides precursors. Mutations in this gene have been associated with susceptibility to obesity and proprotein convertase 1/3 deficiency. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene [provided by RefSeq, Jan 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Substrates include POMC, renin, enkephalin, dynorphin, somatostatin, insulin and AGRP. {ECO:0000250|UniProtKB:P63239}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|P proprotein|
|Proho convert|
|Peptidase S8|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|peptide hormone processing|
|transport vesicle|
|secretory granule lumen|
|protein processing|
|serine-type endopeptidase activity|
|hormone metabolic process|
|protein maturation|
|neuron projection|
|peptide biosynthetic process|
|amide biosynthetic process|
|peptide metabolic process|
|regulation of hormone levels|
|cellular amide metabolic process|
|identical protein binding|
|cell-cell signaling|
|proteolysis|
|organonitrogen compound biosynthetic process|
|extracellular space|
|cellular nitrogen compound biosynthetic process|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp27|Pimelic-diphenylamide-106 0.5μM R00 exp27]]|1.73|
|[[:results:exp13|Chloramphenicol 20μM R00 exp13]]|1.76|
|[[:results:exp11|CCCP 1μM R00 exp11]]|1.85|
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|1.96|
|[[:results:exp23|Nocodazole 0.02μM R00 exp23]]|2.18|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5293
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -3.02 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PCSK1 Expression in NALM6 Cells: -3.02'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>