PDCD11 [The Human Chemical-Genetic Interaction Map Project]

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======= PDCD11 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PDCD11
  * **<color #00a2e8>Official Name</color>**: programmed cell death 11
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=22984|22984]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q14690|Q14690]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PDCD11&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PDCD11|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/612333|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Essential for the generation of mature 18S rRNA, specifically necessary for cleavages at sites A0, 1 and 2 of the 47S precursor. Directly interacts with U3 snoRNA. {ECO:0000269|PubMed:17654514}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Suf|
|S1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|small-subunit processome|
|rRNA processing|
|rRNA metabolic process|
|ribosome biogenesis|
|transcription factor binding|
|ncRNA processing|
|ribonucleoprotein complex biogenesis|
|ncRNA metabolic process|
|mRNA processing|
|mRNA metabolic process|
|nucleolus|
|RNA processing|
|RNA binding|
|RNA metabolic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|-2.68|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|-1.77|
|[[:results:exp208|Vinblastine 0.015μM R05 exp208]]|-1.76|
|[[:results:exp23|Nocodazole 0.02μM R00 exp23]]|1.74|
|[[:results:exp224|CB-839 10μM R05 exp224]]|1.78|
|[[:results:exp182|IU1-47 25μM R04 exp182]]|1.78|
|[[:results:exp409|THZ531 0.11μM R07 exp409]]|1.78|
|[[:results:exp210|LB-100 2μM R05 exp210]]|1.81|
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|1.95|
|[[:results:exp307|Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307]]|1.99|
|[[:results:exp308|Rapamycin 2μM plus FK-506 5μM R07 exp308]]|2|
|[[:results:exp477|DKK1 89ng/ml R08 exp477]]|2.51|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:ctage4|CTAGE4]]|0.487|
|[[:human genes:c:chaf1a|CHAF1A]]|0.476|
|[[:human genes:p:psmb2|PSMB2]]|0.465|
|[[:human genes:g:golga6l1|GOLGA6L1]]|0.462|
|[[:human genes:z:znf830|ZNF830]]|0.461|
|[[:human genes:h:hgc6.3|HGC6.3]]|0.454|
|[[:human genes:d:ddt|DDT]]|0.44|
|[[:human genes:c:ctage9|CTAGE9]]|0.439|
|[[:human genes:p:psmd11|PSMD11]]|0.438|
|[[:human genes:p:psmc2|PSMC2]]|0.436|
|[[:human genes:n:nsf|NSF]]|0.428|
|[[:human genes:p:psmb4|PSMB4]]|0.425|
|[[:human genes:p:paf1|PAF1]]|0.423|
|[[:human genes:d:ddtl|DDTL]]|0.422|
|[[:human genes:r:rps12|RPS12]]|0.419|
|[[:human genes:p:pole|POLE]]|0.417|
|[[:human genes:i:ik|IK]]|0.415|
|[[:human genes:d:dimt1|DIMT1]]|0.415|
|[[:human genes:p:psma6|PSMA6]]|0.411|
|[[:human genes:s:scgb1c1|SCGB1C1]]|0.41|
|[[:human genes:c:cope|COPE]]|0.41|
|[[:human genes:l:lrr1|LRR1]]|0.409|
|[[:human genes:c:cdca3|CDCA3]]|0.409|
|[[:human genes:t:tceb3c|TCEB3C]]|0.409|
|[[:human genes:p:psmd1|PSMD1]]|0.409|
|[[:human genes:r:rps3|RPS3]]|0.408|
|[[:human genes:k:krt78|KRT78]]|0.405|
|[[:human genes:c:cbwd3|CBWD3]]|0.402|
|[[:human genes:r:rps19|RPS19]]|0.402|
|[[:human genes:c:cbwd5|CBWD5]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 715/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|27/28|
|blood|24/28|
|bone|25/26|
|breast|31/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|15/16|
|kidney|20/21|
|liver|18/20|
|lung|74/75|
|lymphocyte|16/16|
|ovary|26/26|
|pancreas|23/24|
|peripheral nervous system|15/16|
|plasma cell|14/15|
|prostate|0/1|
|skin|24/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|29/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 51
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.57 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PDCD11 Expression in NALM6 Cells: 8.57'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>