PDCD5 [The Human Chemical-Genetic Interaction Map Project]

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======= PDCD5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PDCD5
  * **<color #00a2e8>Official Name</color>**: programmed cell death 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9141|9141]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O14737|O14737]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PDCD5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PDCD5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604583|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May function in the process of apoptosis.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|dsDNA bind|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of protein import into mitochondrial outer membrane|
|negative regulation of chaperone-mediated protein folding|
|regulation of protein import into mitochondrial outer membrane|
|acetyltransferase activator activity|
|regulation of chaperone-mediated protein folding|
|negative regulation of protein folding|
|regulation of protein folding|
|positive regulation of release of cytochrome c from mitochondria|
|positive regulation of protein targeting to mitochondrion|
|beta-tubulin binding|
|positive regulation of protein import|
|regulation of protein targeting to mitochondrion|
|regulation of release of cytochrome c from mitochondria|
|positive regulation of establishment of protein localization to mitochondrion|
|regulation of protein import|
|regulation of establishment of protein localization to mitochondrion|
|regulation of protein targeting|
|positive regulation of mitochondrion organization|
|positive regulation of protein localization to membrane|
|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|positive regulation of cysteine-type endopeptidase activity|
|positive regulation of intracellular protein transport|
|cellular response to transforming growth factor beta stimulus|
|response to transforming growth factor beta|
|heparin binding|
|positive regulation of endopeptidase activity|
|positive regulation of apoptotic signaling pathway|
|regulation of mitochondrion organization|
|regulation of protein localization to membrane|
|positive regulation of peptidase activity|
|positive regulation of intracellular transport|
|regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|regulation of intracellular protein transport|
|regulation of cysteine-type endopeptidase activity|
|positive regulation of cellular protein localization|
|regulation of intracellular transport|
|positive regulation of proteolysis|
|regulation of apoptotic signaling pathway|
|regulation of endopeptidase activity|
|positive regulation of protein transport|
|regulation of peptidase activity|
|positive regulation of establishment of protein localization|
|cellular response to growth factor stimulus|
|response to growth factor|
|regulation of cellular protein localization|
|positive regulation of organelle organization|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|negative regulation of cell population proliferation|
|positive regulation of cell death|
|regulation of protein transport|
|regulation of proteolysis|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|positive regulation of hydrolase activity|
|regulation of cellular localization|
|apoptotic process|
|positive regulation of transport|
|regulation of protein localization|
|programmed cell death|
|cell death|
|positive regulation of cellular component organization|
|cellular response to endogenous stimulus|
|regulation of hydrolase activity|
|regulation of organelle organization|
|positive regulation of catalytic activity|
|DNA binding|
|response to endogenous stimulus|
|regulation of apoptotic process|
|regulation of programmed cell death|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|positive regulation of signal transduction|
|regulation of cell death|
|positive regulation of protein metabolic process|
|positive regulation of molecular function|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of transport|
|positive regulation of gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|-2.73|
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|-2.63|
|[[:results:exp27|Pimelic-diphenylamide-106 0.5μM R00 exp27]]|-2.45|
|[[:results:exp278|CVT-10216 0.1μM R06 exp278]]|-2.29|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|-2.27|
|[[:results:exp179|Combretastatin A4 0.002 to 0.003μM day4 R04 exp179]]|-2.12|
|[[:results:exp437|Ethanol 0.003 R08 exp437]]|-2.03|
|[[:results:exp225|Celastrol 0.12μM R05 exp225]]|-1.99|
|[[:results:exp238|Parthenolide 2.5μM R05 exp238]]|-1.9|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|-1.83|
|[[:results:exp198|Etoposide 0.1μM R05 exp198]]|1.72|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|1.73|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|1.75|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|1.82|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|1.9|
|[[:results:exp359|FK-506 30μM R07 exp359]]|1.91|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|1.95|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|1.95|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|2.02|
|[[:results:exp47|Lapatinib 5μM R01 exp47]]|2.07|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|2.1|
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|2.13|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|2.14|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|2.15|
|[[:results:exp67|BVD-523 15μM R02 exp67]]|2.33|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|2.34|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|2.58|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hars|HARS]]|0.578|
|[[:human genes:s:sssca1|SSSCA1]]|0.527|
|[[:human genes:v:vbp1|VBP1]]|0.515|
|[[:human genes:v:vezt|VEZT]]|0.465|
|[[:human genes:t:tbcb|TBCB]]|0.453|
|[[:human genes:t:trip12|TRIP12]]|0.452|
|[[:human genes:d:dohh|DOHH]]|0.449|
|[[:human genes:c:c15orf41|C15orf41]]|0.439|
|[[:human genes:d:dhrsx|DHRSX]]|0.437|
|[[:human genes:u:urm1|URM1]]|0.435|
|[[:human genes:g:gemin7|GEMIN7]]|0.429|
|[[:human genes:t:thg1l|THG1L]]|0.427|
|[[:human genes:t:tcp1|TCP1]]|0.425|
|[[:human genes:a:alg13|ALG13]]|0.422|
|[[:human genes:m:msto1|MSTO1]]|0.42|
|[[:human genes:z:zcrb1|ZCRB1]]|0.417|
|[[:human genes:e:elp3|ELP3]]|0.417|
|[[:human genes:m:mrps5|MRPS5]]|0.416|
|[[:human genes:t:tmem242|TMEM242]]|0.416|
|[[:human genes:t:tsen54|TSEN54]]|0.414|
|[[:human genes:p:ppp6c|PPP6C]]|0.411|
|[[:human genes:n:nsd1|NSD1]]|0.409|
|[[:human genes:p:pfdn4|PFDN4]]|0.409|
|[[:human genes:t:ten1|TEN1]]|0.408|
|[[:human genes:e:elac2|ELAC2]]|0.407|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.406|
|[[:human genes:d:dnlz|DNLZ]]|0.405|
|[[:human genes:m:mrps14|MRPS14]]|0.405|
|[[:human genes:b:bcs1l|BCS1L]]|0.401|
|[[:human genes:r:rptor|RPTOR]]|0.401|
|[[:human genes:p:pfdn1|PFDN1]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 33/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|2/28|
|blood|1/28|
|bone|2/26|
|breast|0/33|
|central nervous system|4/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|1/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|1/20|
|lung|4/75|
|lymphocyte|1/16|
|ovary|1/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|1/9|
|thyroid|0/2|
|upper aerodigestive|3/22|
|urinary tract|3/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6266
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.08 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PDCD5 Expression in NALM6 Cells: 6.08'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>