PDE4B [The Human Chemical-Genetic Interaction Map Project]

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======= PDE4B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PDE4B
  * **<color #00a2e8>Official Name</color>**: phosphodiesterase 4B
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5142|5142]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q07343|Q07343]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PDE4B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PDE4B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600127|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. The encoded protein regulates the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents. {ECO:0000269|PubMed:10846163, ECO:0000269|PubMed:15003452}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PDEase I|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of relaxation of cardiac muscle|
|negative regulation of relaxation of muscle|
|regulation of relaxation of cardiac muscle|
|cAMP catabolic process|
|neutrophil homeostasis|
|regulation of relaxation of muscle|
|3,5-cyclic-AMP phosphodiesterase activity|
|cellular response to epinephrine stimulus|
|cyclic nucleotide catabolic process|
|gamma-tubulin complex|
|regulation of high voltage-gated calcium channel activity|
|response to epinephrine|
|cAMP metabolic process|
|cAMP binding|
|gamma-tubulin binding|
|voltage-gated calcium channel complex|
|positive regulation of interleukin-2 production|
|excitatory synapse|
|purine ribonucleotide catabolic process|
|ribonucleotide catabolic process|
|regulation of voltage-gated calcium channel activity|
|regulation of cardiac muscle cell contraction|
|cyclic nucleotide metabolic process|
|regulation of actin filament-based movement|
|purine nucleotide catabolic process|
|purine-containing compound catabolic process|
|regulation of interleukin-2 production|
|positive regulation of interferon-gamma production|
|nucleotide catabolic process|
|leukocyte homeostasis|
|nucleoside phosphate catabolic process|
|regulation of cardiac muscle contraction|
|neutrophil chemotaxis|
|regulation of calcium ion transmembrane transporter activity|
|granulocyte chemotaxis|
|regulation of striated muscle contraction|
|neutrophil migration|
|regulation of interferon-gamma production|
|granulocyte migration|
|cellular response to monoamine stimulus|
|cellular response to catecholamine stimulus|
|response to monoamine|
|response to catecholamine|
|nucleobase-containing small molecule biosynthetic process|
|myeloid cell homeostasis|
|synaptic vesicle|
|ion channel binding|
|organophosphate catabolic process|
|myeloid leukocyte migration|
|Z disc|
|leukocyte chemotaxis|
|regulation of calcium ion transmembrane transport|
|dendritic spine|
|regulation of muscle contraction|
|regulation of cation channel activity|
|T cell receptor signaling pathway|
|cellular response to lipopolysaccharide|
|carbohydrate derivative catabolic process|
|cellular response to molecule of bacterial origin|
|homeostasis of number of cells|
|cell chemotaxis|
|cellular response to biotic stimulus|
|regulation of muscle system process|
|regulation of heart contraction|
|regulation of calcium ion transport|
|postsynaptic density|
|regulation of ion transmembrane transporter activity|
|regulation of transmembrane transporter activity|
|regulation of transporter activity|
|regulation of blood circulation|
|antigen receptor-mediated signaling pathway|
|purine ribonucleotide metabolic process|
|response to lipopolysaccharide|
|ribonucleotide metabolic process|
|response to molecule of bacterial origin|
|purine nucleotide metabolic process|
|regulation of cation transmembrane transport|
|ribose phosphate metabolic process|
|purine-containing compound metabolic process|
|nucleobase-containing compound catabolic process|
|leukocyte migration|
|regulation of metal ion transport|
|regulation of actin filament-based process|
|cellular response to drug|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|aromatic compound catabolic process|
|nucleotide metabolic process|
|positive regulation of cytokine production|
|immune response-activating cell surface receptor signaling pathway|
|nucleoside phosphate metabolic process|
|regulation of ion transmembrane transport|
|organic cyclic compound catabolic process|
|immune response-regulating cell surface receptor signaling pathway|
|centrosome|
|cellular response to lipid|
|nucleobase-containing small molecule metabolic process|
|cellular response to organic cyclic compound|
|chemotaxis|
|taxis|
|immune response-activating signal transduction|
|regulation of transmembrane transport|
|small molecule biosynthetic process|
|regulation of system process|
|immune response-regulating signaling pathway|
|cellular response to organonitrogen compound|
|activation of immune response|
|cellular response to nitrogen compound|
|response to bacterium|
|regulation of cytokine production|
|regulation of ion transport|
|response to lipid|
|positive regulation of immune response|
|organophosphate metabolic process|
|response to organic cyclic compound|
|cell migration|
|regulation of cellular component movement|
|response to organonitrogen compound|
|response to drug|
|carbohydrate derivative metabolic process|
|cellular response to oxygen-containing compound|
|organonitrogen compound catabolic process|
|cell motility|
|localization of cell|
|response to nitrogen compound|
|nucleobase-containing compound biosynthetic process|
|positive regulation of immune system process|
|regulation of immune response|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|negative regulation of multicellular organismal process|
|cellular response to endogenous stimulus|
|response to other organism|
|organic cyclic compound biosynthetic process|
|response to external biotic stimulus|
|locomotion|
|G protein-coupled receptor signaling pathway|
|response to biotic stimulus|
|response to endogenous stimulus|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|cellular nitrogen compound biosynthetic process|
|homeostatic process|
|regulation of immune system process|
|positive regulation of multicellular organismal process|
|small molecule metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp475|CyclicAMP 200μM R08 exp475]]|-2.01|
|[[:results:exp273|Cisplatin 0.35μM R06 exp273]]|2.85|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16532
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.75 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PDE4B Expression in NALM6 Cells: 2.75'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>