PDE5A [The Human Chemical-Genetic Interaction Map Project]

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======= PDE5A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PDE5A
  * **<color #00a2e8>Official Name</color>**: phosphodiesterase 5A
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8654|8654]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O76074|O76074]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PDE5A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PDE5A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603310|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'- GMP (PubMed:9714779, PubMed:15489334). Specifically regulates nitric-oxide-generated cGMP (PubMed:15489334). {ECO:0000269|PubMed:15489334, ECO:0000269|PubMed:9714779}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PDEase I|
|GAF|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of oocyte development|
|positive regulation of oogenesis|
|cGMP catabolic process|
|negative regulation of cardiac muscle contraction|
|3,5-cyclic-nucleotide phosphodiesterase activity|
|negative regulation of striated muscle contraction|
|regulation of oocyte development|
|regulation of oogenesis|
|regulation of nitric oxide mediated signal transduction|
|relaxation of cardiac muscle|
|cyclic nucleotide catabolic process|
|cGMP binding|
|3,5-cyclic-GMP phosphodiesterase activity|
|cGMP metabolic process|
|relaxation of muscle|
|negative regulation of muscle contraction|
|negative regulation of heart contraction|
|positive regulation of cardiac muscle hypertrophy|
|positive regulation of muscle hypertrophy|
|purine ribonucleotide catabolic process|
|negative regulation of blood circulation|
|ribonucleotide catabolic process|
|cyclic nucleotide metabolic process|
|purine nucleotide catabolic process|
|purine-containing compound catabolic process|
|regulation of cardiac muscle hypertrophy|
|regulation of muscle hypertrophy|
|negative regulation of T cell proliferation|
|nucleotide catabolic process|
|nucleoside phosphate catabolic process|
|negative regulation of mononuclear cell proliferation|
|negative regulation of lymphocyte proliferation|
|regulation of cardiac muscle contraction|
|positive regulation of reproductive process|
|negative regulation of leukocyte proliferation|
|regulation of muscle adaptation|
|regulation of striated muscle contraction|
|nucleobase-containing small molecule biosynthetic process|
|negative regulation of T cell activation|
|negative regulation of leukocyte cell-cell adhesion|
|organophosphate catabolic process|
|negative regulation of lymphocyte activation|
|regulation of T cell proliferation|
|regulation of muscle contraction|
|regulation of reproductive process|
|negative regulation of leukocyte activation|
|negative regulation of cell-cell adhesion|
|carbohydrate derivative catabolic process|
|negative regulation of cell activation|
|regulation of lymphocyte proliferation|
|regulation of mononuclear cell proliferation|
|regulation of leukocyte proliferation|
|regulation of muscle system process|
|regulation of heart contraction|
|positive regulation of MAP kinase activity|
|negative regulation of cell adhesion|
|regulation of blood circulation|
|regulation of leukocyte cell-cell adhesion|
|muscle system process|
|purine ribonucleotide metabolic process|
|regulation of T cell activation|
|ribonucleotide metabolic process|
|purine nucleotide metabolic process|
|ribose phosphate metabolic process|
|positive regulation of protein serine/threonine kinase activity|
|regulation of MAP kinase activity|
|purine-containing compound metabolic process|
|nucleobase-containing compound catabolic process|
|regulation of cell-cell adhesion|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|negative regulation of immune system process|
|aromatic compound catabolic process|
|nucleotide metabolic process|
|cellular component|
|nucleoside phosphate metabolic process|
|organic cyclic compound catabolic process|
|positive regulation of multi-organism process|
|regulation of lymphocyte activation|
|regulation of protein serine/threonine kinase activity|
|positive regulation of protein kinase activity|
|nucleobase-containing small molecule metabolic process|
|positive regulation of cell development|
|positive regulation of MAPK cascade|
|positive regulation of kinase activity|
|regulation of system process|
|small molecule biosynthetic process|
|regulation of leukocyte activation|
|regulation of cell activation|
|positive regulation of transferase activity|
|negative regulation of cell population proliferation|
|regulation of cell adhesion|
|regulation of MAPK cascade|
|regulation of multi-organism process|
|regulation of protein kinase activity|
|regulation of kinase activity|
|organophosphate metabolic process|
|regulation of cell development|
|positive regulation of cell differentiation|
|regulation of transferase activity|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|carbohydrate derivative metabolic process|
|positive regulation of phosphorylation|
|organonitrogen compound catabolic process|
|nucleobase-containing compound biosynthetic process|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|negative regulation of multicellular organismal process|
|positive regulation of protein modification process|
|organic cyclic compound biosynthetic process|
|positive regulation of developmental process|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|cellular nitrogen compound biosynthetic process|
|positive regulation of signal transduction|
|regulation of immune system process|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|small molecule metabolic process|
|organic substance catabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|cellular catabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp222|Betulinic acid 10 to 15μM on day4 R05 exp222]]|1.8|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6121
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.99 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PDE5A Expression in NALM6 Cells: 2.99'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>