PDHA1 [The Human Chemical-Genetic Interaction Map Project]

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======= PDHA1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PDHA1
  * **<color #00a2e8>Official Name</color>**: pyruvate dehydrogenase E1 subunit alpha 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5160|5160]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P08559|P08559]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PDHA1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PDHA1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/300502|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle. The PDH complex is composed of multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). The E1 enzyme is a heterotetramer of two alpha and two beta subunits. This gene encodes the E1 alpha 1 subunit containing the E1 active site, and plays a key role in the function of the PDH complex. Mutations in this gene are associated with pyruvate dehydrogenase E1-alpha deficiency and X-linked Leigh syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|E1 dh|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|pyruvate dehydrogenase activity|
|pyruvate dehydrogenase (acetyl-transferring) activity|
|pyruvate dehydrogenase (NAD+) activity|
|mitochondrial acetyl-CoA biosynthetic process from pyruvate|
|pyruvate dehydrogenase complex|
|acetyl-CoA biosynthetic process from pyruvate|
|acetyl-CoA biosynthetic process|
|acetyl-CoA metabolic process|
|tricarboxylic acid cycle|
|acyl-CoA biosynthetic process|
|thioester biosynthetic process|
|ribonucleoside bisphosphate biosynthetic process|
|nucleoside bisphosphate biosynthetic process|
|purine nucleoside bisphosphate biosynthetic process|
|pyruvate metabolic process|
|aerobic respiration|
|thioester metabolic process|
|acyl-CoA metabolic process|
|glucose metabolic process|
|nucleoside bisphosphate metabolic process|
|purine nucleoside bisphosphate metabolic process|
|ribonucleoside bisphosphate metabolic process|
|coenzyme biosynthetic process|
|purine ribonucleotide biosynthetic process|
|purine nucleotide biosynthetic process|
|hexose metabolic process|
|ribonucleotide biosynthetic process|
|cellular respiration|
|ribose phosphate biosynthetic process|
|purine-containing compound biosynthetic process|
|sulfur compound biosynthetic process|
|monosaccharide metabolic process|
|cofactor biosynthetic process|
|energy derivation by oxidation of organic compounds|
|nucleotide biosynthetic process|
|nucleoside phosphate biosynthetic process|
|coenzyme metabolic process|
|purine ribonucleotide metabolic process|
|ribonucleotide metabolic process|
|purine nucleotide metabolic process|
|ribose phosphate metabolic process|
|sulfur compound metabolic process|
|purine-containing compound metabolic process|
|mitochondrial matrix|
|generation of precursor metabolites and energy|
|cofactor metabolic process|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|carbohydrate metabolic process|
|amide biosynthetic process|
|monocarboxylic acid metabolic process|
|organophosphate biosynthetic process|
|nucleobase-containing small molecule metabolic process|
|carbohydrate derivative biosynthetic process|
|cellular amide metabolic process|
|nucleolus|
|organophosphate metabolic process|
|carboxylic acid metabolic process|
|oxidation-reduction process|
|oxoacid metabolic process|
|organic acid metabolic process|
|carbohydrate derivative metabolic process|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|mitochondrion|
|organic cyclic compound biosynthetic process|
|organonitrogen compound biosynthetic process|
|cellular nitrogen compound biosynthetic process|
|small molecule metabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp148|SB202190 10μM R03 exp148]]|1.72|
|[[:results:exp14|Cycloheximide 0.02μM R00 exp14]]|1.75|
|[[:results:exp16|DABN 2μM R00 exp16]]|1.75|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|1.76|
|[[:results:exp432|YM155 0.001μM R08 exp432]]|1.76|
|[[:results:exp239|PFI-2 4μM R05 exp239]]|1.77|
|[[:results:exp301|VER-155008 3.9μM R06 exp301]]|1.8|
|[[:results:exp275|Citral 75μM R06 exp275]]|1.85|
|[[:results:exp358|FK-506 5μM R07 exp358]]|1.85|
|[[:results:exp187|proTAME 5μM R04 exp187]]|1.88|
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|1.88|
|[[:results:exp292|Menadione 5μM R06 exp292]]|1.94|
|[[:results:exp12|Chloramphenicol 2μM R00 exp12]]|1.97|
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|1.98|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|2.04|
|[[:results:exp69|Deguelin 0.05μM R02 exp69]]|2.05|
|[[:results:exp431|Rotenone 0.07μM R08 exp431]]|2.05|
|[[:results:exp249|Vinorelbine 0.001μM R05 exp249]]|2.07|
|[[:results:exp209|Deguelin 0.15μM R05 exp209]]|2.2|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|2.33|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|2.39|
|[[:results:exp248|UM0131023 0.05μM R05 exp248]]|3.02|
|[[:results:exp183|IU1-C 25μM R04 exp183]]|3.37|
|[[:results:exp274|Citral 50μM R06 exp274]]|6.08|
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|8.39|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:pdhb|PDHB]]|0.706|
|[[:human genes:m:mpc1|MPC1]]|0.628|
|[[:human genes:d:dlat|DLAT]]|0.614|
|[[:human genes:p:pdhx|PDHX]]|0.593|
|[[:human genes:m:mdh1|MDH1]]|0.559|
|[[:human genes:c:cs|CS]]|0.521|
|[[:human genes:h:hgc6.3|HGC6.3]]|0.478|
|[[:human genes:m:mpc2|MPC2]]|0.417|
|[[:human genes:p:pdp2|PDP2]]|0.412|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/26|
|bone|0/26|
|breast|1/30|
|central nervous system|0/49|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/11|
|fibroblast|0/1|
|gastric|0/14|
|kidney|0/18|
|liver|0/19|
|lung|0/72|
|lymphocyte|0/16|
|ovary|0/25|
|pancreas|0/22|
|peripheral nervous system|0/15|
|plasma cell|0/12|
|prostate|0/1|
|skin|0/20|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/28|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5641
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.55 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PDHA1 Expression in NALM6 Cells: 6.55'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>