PDIA3 [The Human Chemical-Genetic Interaction Map Project]

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======= PDIA3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PDIA3
  * **<color #00a2e8>Official Name</color>**: protein disulfide isomerase family A member 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2923|2923]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P30101|P30101]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PDIA3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PDIA3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602046|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Thioredoxin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|disulfide oxidoreductase activity|
|MHC class I peptide loading complex|
|peptide disulfide oxidoreductase activity|
|phospholipase C activity|
|protein folding in endoplasmic reticulum|
|protein disulfide isomerase activity|
|cellular response to interleukin-7|
|response to interleukin-7|
|positive regulation of extrinsic apoptotic signaling pathway|
|phagocytic vesicle|
|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|
|cell redox homeostasis|
|antigen processing and presentation of exogenous peptide antigen via MHC class I|
|recycling endosome membrane|
|cysteine-type endopeptidase activity|
|antigen processing and presentation of peptide antigen via MHC class I|
|melanosome|
|regulation of extrinsic apoptotic signaling pathway|
|positive regulation of apoptotic signaling pathway|
|antigen processing and presentation of exogenous peptide antigen|
|antigen processing and presentation of exogenous antigen|
|antigen processing and presentation of peptide antigen|
|antigen processing and presentation|
|protein folding|
|response to endoplasmic reticulum stress|
|endoplasmic reticulum lumen|
|regulation of apoptotic signaling pathway|
|focal adhesion|
|cell surface|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|positive regulation of cell death|
|cellular homeostasis|
|oxidation-reduction process|
|cellular response to cytokine stimulus|
|endoplasmic reticulum|
|identical protein binding|
|response to cytokine|
|proteolysis|
|RNA binding|
|regulation of apoptotic process|
|regulation of programmed cell death|
|extracellular space|
|homeostatic process|
|positive regulation of signal transduction|
|regulation of cell death|
|cellular response to stress|
|positive regulation of cell communication|
|positive regulation of signaling|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp307|Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307]]|-2.17|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|-2|
|[[:results:exp362|GSK-J4 1μM R07 exp362]]|-1.98|
|[[:results:exp464|Calcipotriol 5μM R08 exp464]]|-1.83|
|[[:results:exp363|GSK-J4 1-1.25μM to day4 R07 exp363]]|-1.73|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|2.06|
|[[:results:exp293|Myriocin 25μM R06 exp293]]|2.43|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17347
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 10.17 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PDIA3 Expression in NALM6 Cells: 10.17'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>