PDS5B [The Human Chemical-Genetic Interaction Map Project]

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======= PDS5B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PDS5B
  * **<color #00a2e8>Official Name</color>**: PDS5 cohesin associated factor B
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23047|23047]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NTI5|Q9NTI5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PDS5B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PDS5B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605333|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a protein that interacts with the conserved protein complex termed cohesin. The cohesin complex holds together sister chromatids and facilitates accurate chromosome segregation during mitosis and meiosis. This protein is also a negative regulator of cell proliferation and may be a tumor-suppressor gene. [provided by RefSeq, Jul 2015]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Plays a role in androgen-induced proliferative arrest in prostate cells. {ECO:0000269|PubMed:10963680, ECO:0000269|PubMed:15855230, ECO:0000269|PubMed:19696148}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|neuroblast migration|
|mitotic sister chromatid cohesion|
|sister chromatid cohesion|
|chromosome, centromeric region|
|lens development in camera-type eye|
|mitotic sister chromatid segregation|
|chromatin|
|chromosome|
|sister chromatid segregation|
|mitotic nuclear division|
|nuclear chromosome segregation|
|chromosome segregation|
|nuclear division|
|organelle fission|
|camera-type eye development|
|eye development|
|visual system development|
|sensory system development|
|cell division|
|DNA repair|
|sensory organ development|
|cell population proliferation|
|mitotic cell cycle process|
|negative regulation of cell population proliferation|
|mitotic cell cycle|
|DNA metabolic process|
|cellular response to DNA damage stimulus|
|cell migration|
|cell cycle process|
|chromosome organization|
|cell motility|
|localization of cell|
|locomotion|
|cell cycle|
|DNA binding|
|movement of cell or subcellular component|
|regulation of cell population proliferation|
|cellular response to stress|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp125|GSK461364A 0.005μM R03 exp125]]|-3.68|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|-3.6|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|-3.38|
|[[:results:exp17|DABN 20μM R00 exp17]]|-3.35|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|-3.31|
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|-3.27|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|-3.26|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|-3.2|
|[[:results:exp162|BI-D1870 2μM R04 exp162]]|-3.18|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|-3.15|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|-3.14|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|-3.12|
|[[:results:exp59|UMK57 1μM R01 exp59]]|-3.1|
|[[:results:exp312|2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312]]|-3.08|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|-3.07|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|-3|
|[[:results:exp360|Genistein 15μM R07 exp360]]|-3|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|-2.98|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|-2.96|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|-2.93|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|-2.93|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|-2.91|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|-2.87|
|[[:results:exp67|BVD-523 15μM R02 exp67]]|-2.79|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|-2.73|
|[[:results:exp311|2-Methoxyestradiol 0.55 to 0.75μM  on day4 R07 exp311]]|-2.69|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|-2.68|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|-2.58|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|-2.56|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|-2.55|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|-2.49|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|-2.49|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|-2.48|
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|-2.43|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|-2.4|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|-2.36|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|-2.32|
|[[:results:exp343|Centrinone 0.5μM R07 exp343]]|-2.25|
|[[:results:exp179|Combretastatin A4 0.002 to 0.003μM day4 R04 exp179]]|-2.21|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|-2.2|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|-2.19|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|-2.18|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|-2.17|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|-2.14|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|-2.12|
|[[:results:exp79|Q15 2.7μM R02 exp79]]|-2.11|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|-2.04|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|-1.93|
|[[:results:exp26|Oligomycin-A 20μM R00 exp26]]|-1.93|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|-1.91|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|-1.88|
|[[:results:exp8|Brefeldin A 0.02μM R00 exp8]]|-1.87|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|-1.85|
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|-1.82|
|[[:results:exp111|R-DABN 8μM R03 exp111]]|-1.81|
|[[:results:exp128|GSK591 2.6μM R03 exp128]]|-1.79|
|[[:results:exp4|Actinomycin-D 0.01μM R00 exp4]]|-1.78|
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|-1.76|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|-1.75|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|-1.74|
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|-1.74|
|[[:results:exp307|Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307]]|1.78|
|[[:results:exp292|Menadione 5μM R06 exp292]]|1.78|
|[[:results:exp458|Bisphenol S 100μM R08 exp458]]|1.79|
|[[:results:exp148|SB202190 10μM R03 exp148]]|1.81|
|[[:results:exp218|A-395 10μM R05 exp218]]|1.88|
|[[:results:exp333|All-trans-Retinoic-Acid 8μM R07 exp333]]|1.89|
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|2.05|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|2.05|
|[[:results:exp222|Betulinic acid 10 to 15μM on day4 R05 exp222]]|2.11|
|[[:results:exp341|BRD2 inhibitor II 20μM R07 exp341]]|2.11|
|[[:results:exp50|Nicotinamide 2000μM R01 exp50]]|2.13|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|2.16|
|[[:results:exp49|NFN1 0.1μM R01 exp49]]|2.16|
|[[:results:exp438|NN-Diethyl-meta-toluamide 500μM R08 exp438]]|2.17|
|[[:results:exp274|Citral 50μM R06 exp274]]|2.18|
|[[:results:exp51|Nifuroxazide 1μM R01 exp51]]|2.18|
|[[:results:exp362|GSK-J4 1μM R07 exp362]]|2.19|
|[[:results:exp306|Rapamycin 2μM R07 exp306]]|2.19|
|[[:results:exp18|Doxycycline 10μM R00 exp18]]|2.2|
|[[:results:exp390|Pifithrin-alpha 20μM R07 exp390]]|2.22|
|[[:results:exp248|UM0131023 0.05μM R05 exp248]]|2.26|
|[[:results:exp418|Tunicamycin 0.04μM R07 exp418]]|2.32|
|[[:results:exp212|Phenformin 20μM R05 exp212]]|2.33|
|[[:results:exp115|A-366 10μM R03 exp115]]|2.36|
|[[:results:exp275|Citral 75μM R06 exp275]]|2.42|
|[[:results:exp380|NMS-873 0.07μM R07 exp380]]|2.6|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|2.67|
|[[:results:exp210|LB-100 2μM R05 exp210]]|2.79|
|[[:results:exp420|Tunicamycin 0.04 to 0.125μM  on day4 R07 exp420]]|2.88|
|[[:results:exp233|EPZ-5676 30μM R05 exp233]]|2.92|
|[[:results:exp316|Geldanamycin 0.015 to 0.025μM on day4 R07 exp316]]|3.05|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|3.16|
|[[:results:exp419|Tunicamycin 0.04 to 0.075μM  on day4 R07 exp419]]|3.28|
|[[:results:exp317|Geldanamycin 0.015 to 0.05μM on day4 R07 exp317]]|3.33|
|[[:results:exp429|Rapamycin 0.001μM R08 exp429]]|3.98|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|4.1|
|[[:results:exp191|Hypoxia 5%O2 R04 exp191]]|5.03|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:a:arid4b|ARID4B]]|0.685|
|[[:human genes:e:esco1|ESCO1]]|0.563|
|[[:human genes:c:cnot2|CNOT2]]|0.563|
|[[:human genes:a:anp32a|ANP32A]]|0.551|
|[[:human genes:k:kdm6a|KDM6A]]|0.545|
|[[:human genes:p:pcgf1|PCGF1]]|0.509|
|[[:human genes:p:psme3|PSME3]]|0.482|
|[[:human genes:n:nelfb|NELFB]]|0.472|
|[[:human genes:b:brd2|BRD2]]|0.47|
|[[:human genes:i:itpk1|ITPK1]]|0.468|
|[[:human genes:c:cnot3|CNOT3]]|0.468|
|[[:human genes:p:psma7|PSMA7]]|0.455|
|[[:human genes:i:ippk|IPPK]]|0.449|
|[[:human genes:c:ckap5|CKAP5]]|0.441|
|[[:human genes:n:naa50|NAA50]]|0.435|
|[[:human genes:s:sap130|SAP130]]|0.434|
|[[:human genes:e:eif4a3|EIF4A3]]|0.432|
|[[:human genes:c:c12orf66|C12orf66]]|0.432|
|[[:human genes:c:ctnnbl1|CTNNBL1]]|0.425|
|[[:human genes:k:klhdc2|KLHDC2]]|0.425|
|[[:human genes:a:armc8|ARMC8]]|0.424|
|[[:human genes:c:cltc|CLTC]]|0.417|
|[[:human genes:n:nelfa|NELFA]]|0.416|
|[[:human genes:n:nelfe|NELFE]]|0.413|
|[[:human genes:p:prmt7|PRMT7]]|0.413|
|[[:human genes:c:ccdc130|CCDC130]]|0.413|
|[[:human genes:i:ints8|INTS8]]|0.411|
|[[:human genes:u:uty|UTY]]|0.409|
|[[:human genes:i:itfg2|ITFG2]]|0.407|
|[[:human genes:p:psmb4|PSMB4]]|0.407|
|[[:human genes:p:prpf3|PRPF3]]|0.407|
|[[:human genes:s:ssr3|SSR3]]|0.406|
|[[:human genes:n:narfl|NARFL]]|0.406|
|[[:human genes:i:ints6|INTS6]]|0.405|
|[[:human genes:t:tspyl1|TSPYL1]]|0.405|
|[[:human genes:r:rbm38|RBM38]]|0.405|
|[[:human genes:s:sesn2|SESN2]]|0.403|
|[[:human genes:t:tbc1d7|TBC1D7]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 19054
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.29 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PDS5B Expression in NALM6 Cells: 7.29'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>