PDXK [The Human Chemical-Genetic Interaction Map Project]

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======= PDXK =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PDXK
  * **<color #00a2e8>Official Name</color>**: pyridoxal kinase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8566|8566]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O00764|O00764]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PDXK&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PDXK|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/179020|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Required for synthesis of pyridoxal-5-phosphate from vitamin B6.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PfkB|
|Phos pyr kin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|pyridoxal 5-phosphate salvage|
|pyridoxal kinase activity|
|lithium ion binding|
|pyridoxal phosphate biosynthetic process|
|vitamin B6 biosynthetic process|
|pyridoxal phosphate metabolic process|
|vitamin B6 metabolic process|
|aldehyde biosynthetic process|
|sodium ion binding|
|water-soluble vitamin biosynthetic process|
|potassium ion binding|
|vitamin biosynthetic process|
|cellular metabolic compound salvage|
|pyridine-containing compound biosynthetic process|
|pyridine-containing compound metabolic process|
|pyridoxal phosphate binding|
|cellular aldehyde metabolic process|
|specific granule lumen|
|water-soluble vitamin metabolic process|
|secretory granule lumen|
|vitamin metabolic process|
|coenzyme biosynthetic process|
|organic hydroxy compound biosynthetic process|
|cofactor biosynthetic process|
|magnesium ion binding|
|coenzyme metabolic process|
|cofactor metabolic process|
|organic hydroxy compound metabolic process|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|neutrophil mediated immunity|
|drug metabolic process|
|neutrophil activation|
|granulocyte activation|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|myeloid cell activation involved in immune response|
|organophosphate biosynthetic process|
|cell population proliferation|
|myeloid leukocyte activation|
|small molecule biosynthetic process|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|regulated exocytosis|
|leukocyte mediated immunity|
|exocytosis|
|zinc ion binding|
|protein homodimerization activity|
|organophosphate metabolic process|
|leukocyte activation|
|secretion by cell|
|export from cell|
|cell activation|
|immune effector process|
|secretion|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|phosphorylation|
|organic cyclic compound biosynthetic process|
|organonitrogen compound biosynthetic process|
|ATP binding|
|cellular nitrogen compound biosynthetic process|
|small molecule metabolic process|
|immune response|
|extracellular region|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp476|Dihydrosphingosine 8μM R08 exp476]]|-4.45|
|[[:results:exp241|QNZ 0.01μM R05 exp241]]|-3.21|
|[[:results:exp65|Mubritinib 0.2μM R02 exp65]]|-3.01|
|[[:results:exp13|Chloramphenicol 20μM R00 exp13]]|-2.72|
|[[:results:exp212|Phenformin 20μM R05 exp212]]|-2|
|[[:results:exp274|Citral 50μM R06 exp274]]|-1.97|
|[[:results:exp372|Ibrutinib 1μM R07 exp372]]|-1.93|
|[[:results:exp189|Temozolomide 200μM R04 exp189]]|-1.89|
|[[:results:exp143|Phenformin 20μM R03 exp143]]|-1.84|
|[[:results:exp380|NMS-873 0.07μM R07 exp380]]|-1.82|
|[[:results:exp275|Citral 75μM R06 exp275]]|-1.81|
|[[:results:exp139|Nicotinamide Riboside 100μM R03 exp139]]|-1.78|
|[[:results:exp153|SGC2096 2.6μM R03 exp153]]|-1.76|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|-1.71|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|1.82|
|[[:results:exp532|TIC10 10μM R08 exp532]]|1.85|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|2.21|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|3.89|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|6.13|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:cbfb|CBFB]]|0.406|
|[[:human genes:g:glrx5|GLRX5]]|0.404|
|[[:human genes:r:rptor|RPTOR]]|0.402|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6056
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.93 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PDXK Expression in NALM6 Cells: 5.93'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>