PES1 [The Human Chemical-Genetic Interaction Map Project]

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======= PES1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PES1
  * **<color #00a2e8>Official Name</color>**: pescadillo ribosomal biogenesis factor 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23481|23481]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O00541|O00541]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PES1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PES1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605819|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. {ECO:0000255|HAMAP-Rule:MF_03028, ECO:0000269|PubMed:16738141, ECO:0000269|PubMed:17189298, ECO:0000269|PubMed:17353269}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|BRCT|
|Pescadillo N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|PeBoW complex|
|nucleolus organization|
|maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|
|maturation of LSU-rRNA|
|maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|
|preribosome, large subunit precursor|
|condensed chromosome|
|maturation of 5.8S rRNA|
|ribonucleoprotein complex binding|
|ribosomal large subunit biogenesis|
|nucleus organization|
|rRNA processing|
|rRNA metabolic process|
|ribosome biogenesis|
|ncRNA processing|
|ribonucleoprotein complex biogenesis|
|ncRNA metabolic process|
|cell population proliferation|
|protein localization to organelle|
|nucleolus|
|RNA processing|
|regulation of cell cycle|
|RNA binding|
|cellular protein localization|
|cellular macromolecule localization|
|RNA metabolic process|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|-1.72|
|[[:results:exp211|AICAR 240μM R05 exp211]]|-1.71|
|[[:results:exp286|HMS-I2 1μM R06 exp286]]|1.72|
|[[:results:exp219|A-395N 10μM R05 exp219]]|1.76|
|[[:results:exp519|RS-1 10μM R08 exp519]]|1.78|
|[[:results:exp283|Glyphosate 1000μM R06 exp283]]|1.82|
|[[:results:exp151|SGC0946 7μM R03 exp151]]|1.87|
|[[:results:exp533|TNF-alpha 44ng/ml R08 exp533]]|1.91|
|[[:results:exp271|CCT251545 0.2μM R06 exp271]]|1.94|
|[[:results:exp462|Cadmium 60μM R08 exp462]]|1.99|
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|2|
|[[:results:exp281|Disulfiram 4.3μM R06 exp281]]|2.01|
|[[:results:exp148|SB202190 10μM R03 exp148]]|2.01|
|[[:results:exp412|THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412]]|2.03|
|[[:results:exp298|Sucrose 20000μM R06 exp298]]|2.13|
|[[:results:exp242|Radicicol 0.16μM R05 exp242]]|2.19|
|[[:results:exp133|MKC9989 10μM R03 exp133]]|2.25|
|[[:results:exp537|WNT3A 44ng/ml R08 exp537]]|2.25|
|[[:results:exp391|Pomalidomide 20μM R07 exp391]]|2.28|
|[[:results:exp437|Ethanol 0.003 R08 exp437]]|2.46|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:g:golga6l1|GOLGA6L1]]|0.499|
|[[:human genes:z:znf622|ZNF622]]|0.41|
|[[:human genes:n:nip7|NIP7]]|0.41|
|[[:human genes:k:kctd17|KCTD17]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 413/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|13/28|
|blood|10/28|
|bone|14/26|
|breast|21/33|
|central nervous system|38/56|
|cervix|4/4|
|colorectal|8/17|
|esophagus|8/13|
|fibroblast|1/1|
|gastric|10/16|
|kidney|13/21|
|liver|11/20|
|lung|42/75|
|lymphocyte|8/16|
|ovary|17/26|
|pancreas|11/24|
|peripheral nervous system|7/16|
|plasma cell|9/15|
|prostate|1/1|
|skin|12/24|
|soft tissue|7/9|
|thyroid|1/2|
|upper aerodigestive|8/22|
|urinary tract|13/29|
|uterus|4/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 317
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.96 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PES1 Expression in NALM6 Cells: 6.96'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>