PEX10 [The Human Chemical-Genetic Interaction Map Project]

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======= PEX10 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PEX10
  * **<color #00a2e8>Official Name</color>**: peroxisomal biogenesis factor 10
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5192|5192]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O60683|O60683]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PEX10&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PEX10|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602859|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a protein involved in import of peroxisomal matrix proteins. This protein localizes to the peroxisomal membrane. Mutations in this gene result in phenotypes within the Zellweger spectrum of peroxisomal biogenesis disorders, ranging from neonatal adrenoleukodystrophy to Zellweger syndrome. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Somewhat implicated in the biogenesis of peroxisomes.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pex2 Pex12|
|zf-C3HC4|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|protein import into peroxisome matrix|
|peroxisomal membrane transport|
|protein transmembrane import into intracellular organelle|
|intracellular protein transmembrane transport|
|peroxisomal membrane|
|protein transmembrane transport|
|protein localization to peroxisome|
|protein targeting to peroxisome|
|establishment of protein localization to peroxisome|
|peroxisomal transport|
|peroxisome organization|
|peroxisome|
|protein import|
|protein targeting|
|establishment of protein localization to organelle|
|protein ubiquitination|
|protein localization to organelle|
|protein modification by small protein conjugation|
|protein modification by small protein conjugation or removal|
|intracellular protein transport|
|transmembrane transport|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|establishment of localization in cell|
|nitrogen compound transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp180|Dynasore 10μM R04 exp180]]|-2.1|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|-1.85|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|-1.8|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|-1.73|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|2.29|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:pex5|PEX5]]|0.578|
|[[:human genes:h:hgc6.3|HGC6.3]]|0.574|
|[[:human genes:p:pex26|PEX26]]|0.535|
|[[:human genes:p:pex12|PEX12]]|0.516|
|[[:human genes:p:pex1|PEX1]]|0.491|
|[[:human genes:p:pex13|PEX13]]|0.479|
|[[:human genes:p:pex6|PEX6]]|0.473|
|[[:human genes:a:agps|AGPS]]|0.444|
|[[:human genes:p:pex14|PEX14]]|0.43|
|[[:human genes:p:pex2|PEX2]]|0.411|
|[[:human genes:p:pex3|PEX3]]|0.406|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|1/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1992
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.93 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PEX10 Expression in NALM6 Cells: 3.93'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>