PEX14 [The Human Chemical-Genetic Interaction Map Project]

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======= PEX14 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PEX14
  * **<color #00a2e8>Official Name</color>**: peroxisomal biogenesis factor 14
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5195|5195]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O75381|O75381]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PEX14&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PEX14|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601791|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes an essential component of the peroxisomal import machinery. The protein is integrated into peroxisome membranes with its C-terminus exposed to the cytosol, and interacts with the cytosolic receptor for proteins containing a PTS1 peroxisomal targeting signal. The protein also functions as a transcriptional corepressor and interacts with a histone deacetylase. A mutation in this gene results in one form of Zellweger syndrome. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Peroxisome membrane protein that is an essential component of the peroxisomal import machinery. Functions as a docking factor for the predominantly cytoplasmic PTS1 receptor (PEX5). Plays a key role for peroxisome movement through a direct interaction with tubulin. {ECO:0000269|PubMed:21525035, ECO:0000269|PubMed:9653144}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pex14 N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|protein import into peroxisome matrix, substrate release|
|peroxisome transport along microtubule|
|regulation of protein homotetramerization|
|negative regulation of protein homotetramerization|
|protein import into peroxisome matrix, translocation|
|negative regulation of protein tetramerization|
|regulation of protein tetramerization|
|peroxisomal importomer complex|
|protein import into peroxisome matrix, docking|
|negative regulation of protein homooligomerization|
|protein import into peroxisome matrix|
|negative regulation of protein oligomerization|
|peroxisomal membrane transport|
|regulation of protein homooligomerization|
|microtubule anchoring|
|protein transmembrane import into intracellular organelle|
|beta-tubulin binding|
|regulation of protein oligomerization|
|intracellular protein transmembrane transport|
|peroxisomal membrane|
|protein transmembrane transport|
|protein targeting to peroxisome|
|protein localization to peroxisome|
|establishment of protein localization to peroxisome|
|peroxisomal transport|
|organelle transport along microtubule|
|peroxisome organization|
|negative regulation of protein binding|
|protein N-terminus binding|
|peroxisome|
|negative regulation of protein complex assembly|
|fibrillar center|
|cellular protein complex disassembly|
|protein import|
|transport along microtubule|
|negative regulation of DNA-binding transcription factor activity|
|negative regulation of binding|
|cytoskeleton-dependent intracellular transport|
|microtubule-based transport|
|regulation of protein binding|
|microtubule binding|
|protein-containing complex disassembly|
|transcription corepressor activity|
|microtubule-based movement|
|signaling receptor binding|
|protein homooligomerization|
|protein targeting|
|establishment of organelle localization|
|regulation of binding|
|cellular component disassembly|
|regulation of DNA-binding transcription factor activity|
|establishment of protein localization to organelle|
|regulation of protein complex assembly|
|microtubule cytoskeleton organization|
|protein complex oligomerization|
|organelle localization|
|protein-containing complex|
|microtubule-based process|
|protein ubiquitination|
|negative regulation of cellular component organization|
|protein localization to organelle|
|protein modification by small protein conjugation|
|regulation of cellular component biogenesis|
|protein modification by small protein conjugation or removal|
|intracellular protein transport|
|cytoskeleton organization|
|negative regulation of molecular function|
|negative regulation of transcription, DNA-templated|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|transmembrane transport|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|protein transport|
|negative regulation of cellular biosynthetic process|
|intracellular transport|
|peptide transport|
|negative regulation of biosynthetic process|
|movement of cell or subcellular component|
|protein-containing complex assembly|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|negative regulation of gene expression|
|establishment of localization in cell|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp485|GSK626616 14μM R08 exp485]]|1.73|
|[[:results:exp504|MK2206 4μM R08 exp504]]|1.93|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|2.34|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|2.36|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:pex1|PEX1]]|0.522|
|[[:human genes:p:pex6|PEX6]]|0.481|
|[[:human genes:p:pex12|PEX12]]|0.448|
|[[:human genes:p:pex26|PEX26]]|0.438|
|[[:human genes:p:pex10|PEX10]]|0.43|
|[[:human genes:p:pex7|PEX7]]|0.429|
|[[:human genes:a:agps|AGPS]]|0.423|
|[[:human genes:p:pex5|PEX5]]|0.402|
|[[:human genes:p:pex13|PEX13]]|0.402|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11742
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.08 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PEX14 Expression in NALM6 Cells: 4.08'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>