PEX7 [The Human Chemical-Genetic Interaction Map Project]

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======= PEX7 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PEX7
  * **<color #00a2e8>Official Name</color>**: peroxisomal biogenesis factor 7
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5191|5191]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O00628|O00628]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PEX7&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PEX7|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601757|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes the cytosolic receptor for the set of peroxisomal matrix enzymes targeted to the organelle by the peroxisome targeting signal 2 (PTS2). Defects in this gene cause peroxisome biogenesis disorders (PBDs), which are characterized by multiple defects in peroxisome function. There are at least 14 complementation groups for PBDs, with more than one phenotype being observed in cases falling into particular complementation groups. Although the clinical features of PBD patients vary, cells from all PBD patients exhibit a defect in the import of one or more classes of peroxisomal matrix proteins into the organelle. Defects in this gene have been associated with PBD complementation group 11 (PBD-CG11) disorders, rhizomelic chondrodysplasia punctata type 1 (RCDP1), and Refsum disease (RD). [provided by RefSeq, Oct 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Binds to the N-terminal PTS2-type peroxisomal targeting signal and plays an essential role in peroxisomal protein import.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|WD40|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|peroxisome matrix targeting signal-2 binding|
|ether lipid biosynthetic process|
|glycerol ether biosynthetic process|
|ether biosynthetic process|
|cellular lipid biosynthetic process|
|ether lipid metabolic process|
|glycerol ether metabolic process|
|protein import into peroxisome matrix|
|ether metabolic process|
|peroxisomal membrane transport|
|replacement ossification|
|endochondral ossification|
|protein transmembrane import into intracellular organelle|
|intracellular protein transmembrane transport|
|peroxisomal matrix|
|fatty acid beta-oxidation|
|peroxisomal membrane|
|protein transmembrane transport|
|establishment of protein localization to peroxisome|
|protein localization to peroxisome|
|protein targeting to peroxisome|
|peroxisomal transport|
|endochondral bone morphogenesis|
|fatty acid oxidation|
|lipid oxidation|
|peroxisome organization|
|fatty acid catabolic process|
|peroxisome|
|bone morphogenesis|
|monocarboxylic acid catabolic process|
|neuron migration|
|protein import|
|cellular lipid catabolic process|
|bone development|
|lipid modification|
|skeletal system morphogenesis|
|ossification|
|carboxylic acid catabolic process|
|organic acid catabolic process|
|lipid catabolic process|
|fatty acid metabolic process|
|enzyme binding|
|protein targeting|
|establishment of protein localization to organelle|
|small molecule catabolic process|
|skeletal system development|
|monocarboxylic acid metabolic process|
|lipid biosynthetic process|
|protein localization to organelle|
|protein homodimerization activity|
|carboxylic acid metabolic process|
|animal organ morphogenesis|
|cellular lipid metabolic process|
|oxidation-reduction process|
|cell migration|
|intracellular protein transport|
|oxoacid metabolic process|
|organic acid metabolic process|
|cell motility|
|localization of cell|
|lipid metabolic process|
|transmembrane transport|
|locomotion|
|protein transport|
|intracellular transport|
|generation of neurons|
|peptide transport|
|movement of cell or subcellular component|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|neurogenesis|
|small molecule metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp436|Dynasore 7μM R08 exp436]]|-3.53|
|[[:results:exp180|Dynasore 10μM R04 exp180]]|-2.85|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|-2.63|
|[[:results:exp247|UM0130462 0.025 to 0.035μM day4 R05 exp247]]|-2.59|
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|-2.52|
|[[:results:exp410|THZ531 0.11 to 0.125μM on day4 R07 exp410]]|-2.41|
|[[:results:exp399|Salubrinal 20μM R07 exp399]]|-2.3|
|[[:results:exp14|Cycloheximide 0.02μM R00 exp14]]|-2.27|
|[[:results:exp490|Hydroxychloroquine 30μM R08 exp490]]|-2.18|
|[[:results:exp124|GSK343 3μM R03 exp124]]|-2.13|
|[[:results:exp219|A-395N 10μM R05 exp219]]|-2.12|
|[[:results:exp508|NN-Dimethylsphingosine 2.5μM R08 exp508]]|-2.1|
|[[:results:exp5|Alpha-Amanitin 0.5μM R00 exp5]]|-2.05|
|[[:results:exp164|Q15 1 to 2μM on day4 R04 exp164]]|-2.04|
|[[:results:exp26|Oligomycin-A 20μM R00 exp26]]|-1.97|
|[[:results:exp344|Chlorpromazine 10μM R07 exp344]]|-1.91|
|[[:results:exp131|L-74142 5μM R03 exp131]]|-1.87|
|[[:results:exp27|Pimelic-diphenylamide-106 0.5μM R00 exp27]]|-1.87|
|[[:results:exp432|YM155 0.001μM R08 exp432]]|-1.87|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|-1.83|
|[[:results:exp533|TNF-alpha 44ng/ml R08 exp533]]|-1.81|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|-1.79|
|[[:results:exp16|DABN 2μM R00 exp16]]|-1.74|
|[[:results:exp233|EPZ-5676 30μM R05 exp233]]|-1.73|
|[[:results:exp379|MSC2530818 10μM R07 exp379]]|-1.73|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|1.7|
|[[:results:exp536|Vitamin-D3 40μM R08 exp536]]|1.74|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|1.79|
|[[:results:exp179|Combretastatin A4 0.002 to 0.003μM day4 R04 exp179]]|1.9|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|1.93|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|1.96|
|[[:results:exp65|Mubritinib 0.2μM R02 exp65]]|2.01|
|[[:results:exp504|MK2206 4μM R08 exp504]]|2.18|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|2.35|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:pex1|PEX1]]|0.61|
|[[:human genes:p:pex12|PEX12]]|0.537|
|[[:human genes:p:pex2|PEX2]]|0.52|
|[[:human genes:p:pex6|PEX6]]|0.516|
|[[:human genes:p:pex13|PEX13]]|0.499|
|[[:human genes:a:agps|AGPS]]|0.472|
|[[:human genes:l:ldlr|LDLR]]|0.438|
|[[:human genes:p:pcyt2|PCYT2]]|0.431|
|[[:human genes:p:pex14|PEX14]]|0.429|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15455
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.39 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PEX7 Expression in NALM6 Cells: -0.39'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>