PFDN1 [The Human Chemical-Genetic Interaction Map Project]

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======= PFDN1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PFDN1
  * **<color #00a2e8>Official Name</color>**: prefoldin subunit 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5201|5201]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O60925|O60925]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PFDN1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PFDN1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604897|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Prefoldin 2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|prefoldin complex|
|protein folding chaperone|
|unfolded protein binding|
|protein folding|
|DNA-binding transcription factor activity|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|-2.49|
|[[:results:exp526|Sulforaphane 9μM R08 exp526 no dilution day6]]|-2.03|
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|-1.98|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|-1.84|
|[[:results:exp243|S-trityl-L-cysteine 0.5μM R05 exp243]]|-1.7|
|[[:results:exp231|Epothilone-B 0.0015μM R05 exp231]]|1.74|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|1.97|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:v:vbp1|VBP1]]|0.528|
|[[:human genes:s:sssca1|SSSCA1]]|0.465|
|[[:human genes:p:pfdn5|PFDN5]]|0.459|
|[[:human genes:p:pfdn4|PFDN4]]|0.418|
|[[:human genes:t:tcp1|TCP1]]|0.415|
|[[:human genes:p:pdcd5|PDCD5]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 333/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|11/28|
|blood|7/28|
|bone|14/26|
|breast|10/33|
|central nervous system|29/56|
|cervix|3/4|
|colorectal|6/17|
|esophagus|6/13|
|fibroblast|1/1|
|gastric|6/16|
|kidney|8/21|
|liver|7/20|
|lung|32/75|
|lymphocyte|4/16|
|ovary|10/26|
|pancreas|16/24|
|peripheral nervous system|4/16|
|plasma cell|5/15|
|prostate|0/1|
|skin|12/24|
|soft tissue|3/9|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|17/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15827
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.98 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PFDN1 Expression in NALM6 Cells: 4.98'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>