PFDN6 [The Human Chemical-Genetic Interaction Map Project]

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======= PFDN6 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PFDN6
  * **<color #00a2e8>Official Name</color>**: prefoldin subunit 6
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10471|10471]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O15212|O15212]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PFDN6&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PFDN6|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605660|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. {ECO:0000269|PubMed:9630229}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Prefoldin 2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|prefoldin complex|
|chaperone-mediated protein complex assembly|
|chaperone binding|
|unfolded protein binding|
|protein folding|
|cellular protein-containing complex assembly|
|protein-containing complex assembly|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp143|Phenformin 20μM R03 exp143]]|-2.07|
|[[:results:exp155|UNC1999 2μM R03 exp155]]|-1.75|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 672/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|25/28|
|blood|25/28|
|bone|23/26|
|breast|29/33|
|central nervous system|52/56|
|cervix|4/4|
|colorectal|15/17|
|esophagus|11/13|
|fibroblast|1/1|
|gastric|15/16|
|kidney|16/21|
|liver|19/20|
|lung|69/75|
|lymphocyte|13/16|
|ovary|25/26|
|pancreas|24/24|
|peripheral nervous system|12/16|
|plasma cell|13/15|
|prostate|0/1|
|skin|22/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|26/29|
|uterus|4/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1187
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.36 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PFDN6 Expression in NALM6 Cells: 5.36'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>