PFN1 [The Human Chemical-Genetic Interaction Map Project]

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======= PFN1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PFN1
  * **<color #00a2e8>Official Name</color>**: profilin 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5216|5216]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P07737|P07737]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PFN1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PFN1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/176610|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the profilin family of small actin-binding proteins. The encoded protein plays an important role in actin dynamics by regulating actin polymerization in response to extracellular signals. Deletion of this gene is associated with Miller-Dieker syndrome, and the encoded protein may also play a role in Huntington disease. Multiple pseudogenes of this gene are located on chromosome 1. [provided by RefSeq, Jul 2012]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Inhibits androgen receptor (AR) and HTT aggregation and binding of G-actin is essential for its inhibition of AR. {ECO:0000269|PubMed:18573880}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Profilin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|modification of postsynaptic actin cytoskeleton|
|modification of postsynaptic structure|
|adenyl-nucleotide exchange factor activity|
|synapse maturation|
|modification of synaptic structure|
|positive regulation of ruffle assembly|
|proline-rich region binding|
|negative regulation of stress fiber assembly|
|negative regulation of actin filament bundle assembly|
|actin monomer binding|
|regulation of ruffle assembly|
|Rho GTPase binding|
|negative regulation of actin filament polymerization|
|positive regulation of ATPase activity|
|positive regulation of actin filament bundle assembly|
|negative regulation of protein polymerization|
|phosphatidylinositol-4,5-bisphosphate binding|
|regulation of stress fiber assembly|
|regulation of ATPase activity|
|regulation of actomyosin structure organization|
|neural tube closure|
|positive regulation of actin filament polymerization|
|tube closure|
|regulation of actin filament bundle assembly|
|Wnt signaling pathway, planar cell polarity pathway|
|primary neural tube formation|
|positive regulation of plasma membrane bounded cell projection assembly|
|neural tube formation|
|regulation of establishment of planar polarity|
|embryonic epithelial tube formation|
|positive regulation of protein polymerization|
|negative regulation of supramolecular fiber organization|
|negative regulation of protein complex assembly|
|epithelial tube formation|
|non-canonical Wnt signaling pathway|
|cell cortex|
|negative regulation of cytoskeleton organization|
|positive regulation of epithelial cell migration|
|blood microparticle|
|morphogenesis of embryonic epithelium|
|tube formation|
|neural tube development|
|regulation of actin filament polymerization|
|protein stabilization|
|regulation of morphogenesis of an epithelium|
|regulation of actin polymerization or depolymerization|
|regulation of actin filament length|
|positive regulation of supramolecular fiber organization|
|regulation of plasma membrane bounded cell projection assembly|
|regulation of cell projection assembly|
|positive regulation of cytoskeleton organization|
|regulation of epithelial cell migration|
|regulation of protein polymerization|
|developmental maturation|
|positive regulation of protein complex assembly|
|regulation of animal organ morphogenesis|
|regulation of actin filament organization|
|actin binding|
|synapse organization|
|regulation of protein stability|
|epithelial tube morphogenesis|
|cadherin binding|
|regulation of actin cytoskeleton organization|
|glutamatergic synapse|
|regulation of supramolecular fiber organization|
|Wnt signaling pathway|
|cell-cell signaling by wnt|
|cytoskeleton|
|negative regulation of organelle organization|
|regulation of cellular component size|
|positive regulation of cell projection organization|
|regulation of actin filament-based process|
|focal adhesion|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|morphogenesis of an epithelium|
|regulation of protein complex assembly|
|actin cytoskeleton organization|
|positive regulation of cell migration|
|regulation of anatomical structure size|
|positive regulation of cellular component biogenesis|
|positive regulation of cell motility|
|positive regulation of cellular component movement|
|regulation of cytoskeleton organization|
|positive regulation of locomotion|
|tissue morphogenesis|
|embryonic morphogenesis|
|actin filament-based process|
|positive regulation of organelle organization|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|tube morphogenesis|
|regulation of plasma membrane bounded cell projection organization|
|negative regulation of cellular component organization|
|regulation of cell projection organization|
|positive regulation of hydrolase activity|
|tube development|
|regulation of cell migration|
|anatomical structure formation involved in morphogenesis|
|regulation of cell motility|
|regulation of cellular component biogenesis|
|embryo development|
|regulation of locomotion|
|regulation of cellular component movement|
|regulation of anatomical structure morphogenesis|
|cytoskeleton organization|
|epithelium development|
|cell-cell signaling|
|positive regulation of cellular component organization|
|regulation of hydrolase activity|
|regulation of organelle organization|
|RNA binding|
|positive regulation of catalytic activity|
|positive regulation of multicellular organismal process|
|tissue development|
|positive regulation of molecular function|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp534|Trientine 500μM R08 exp534]]|-2.15|
|[[:results:exp42|BI-6727 0.001μM R01 exp42]]|-2.03|
|[[:results:exp291|LLY-284 2.6μM R06 exp291]]|-2.03|
|[[:results:exp31|Rifampicin 1μM R00 exp31]]|-1.98|
|[[:results:exp54|Taxol 0.002μM R01 exp54]]|-1.98|
|[[:results:exp1|5-Fluorouracil 2μM R00 exp1]]|-1.94|
|[[:results:exp348|Cyclosporin-A 3μM R07 exp348]]|-1.93|
|[[:results:exp52|Ribavirin 10μM R01 exp52]]|-1.85|
|[[:results:exp289|Hydroxyurea 15μM R06 exp289]]|-1.81|
|[[:results:exp58|UM131593 0.1μM R01 exp58]]|-1.8|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|-1.78|
|[[:results:exp41|BI-2536 0.001μM R01 exp41]]|-1.73|
|[[:results:exp463|Caffeine 2600μM R08 exp463]]|-1.72|
|[[:results:exp446|4-Nitroquinoline-1-oxide 0.5μM R08 exp446]]|-1.71|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|-1.71|
|[[:results:exp72|LB-100 4.1μM R02 exp72]]|1.75|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|1.85|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|2.05|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|2.09|
|[[:results:exp343|Centrinone 0.5μM R07 exp343]]|2.13|
|[[:results:exp135|MS023 7μM R03 exp135]]|2.85|
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|2.88|
|[[:results:exp536|Vitamin-D3 40μM R08 exp536]]|3.49|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|3.68|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:trim28|TRIM28]]|0.484|
|[[:human genes:f:flii|FLII]]|0.469|
|[[:human genes:c:cmtr1|CMTR1]]|0.465|
|[[:human genes:b:bap1|BAP1]]|0.435|
|[[:human genes:p:pam16|PAM16]]|0.416|
|[[:human genes:w:wdr1|WDR1]]|0.409|
|[[:human genes:d:dohh|DOHH]]|0.408|
|[[:human genes:d:ddx42|DDX42]]|0.408|
|[[:human genes:c:c14orf80|C14orf80]]|0.406|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 308/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|13/28|
|blood|19/28|
|bone|11/26|
|breast|14/33|
|central nervous system|18/56|
|cervix|0/4|
|colorectal|13/17|
|esophagus|3/13|
|fibroblast|1/1|
|gastric|7/16|
|kidney|8/21|
|liver|13/20|
|lung|27/75|
|lymphocyte|10/16|
|ovary|10/26|
|pancreas|14/24|
|peripheral nervous system|3/16|
|plasma cell|11/15|
|prostate|1/1|
|skin|8/24|
|soft tissue|6/9|
|thyroid|2/2|
|upper aerodigestive|10/22|
|urinary tract|9/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1922
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.63 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PFN1 Expression in NALM6 Cells: 8.63'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>