PHACTR3 [The Human Chemical-Genetic Interaction Map Project]

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======= PHACTR3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PHACTR3
  * **<color #00a2e8>Official Name</color>**: phosphatase and actin regulator 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=116154|116154]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96KR7|Q96KR7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PHACTR3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PHACTR3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608725|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the phosphatase and actin regulator protein family. The encoded protein is associated with the nuclear scaffold in proliferating cells, and binds to actin and the catalytic subunit of protein phosphatase-1, suggesting that it functions as a regulatory subunit of protein phosphatase-1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RPEL|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|protein phosphatase 1 binding|
|protein phosphatase inhibitor activity|
|negative regulation of phosphoprotein phosphatase activity|
|negative regulation of protein dephosphorylation|
|negative regulation of phosphatase activity|
|nuclear matrix|
|negative regulation of dephosphorylation|
|regulation of phosphoprotein phosphatase activity|
|regulation of protein dephosphorylation|
|regulation of phosphatase activity|
|regulation of dephosphorylation|
|actin binding|
|negative regulation of hydrolase activity|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|negative regulation of protein modification process|
|negative regulation of catalytic activity|
|negative regulation of cellular protein metabolic process|
|negative regulation of protein metabolic process|
|negative regulation of molecular function|
|regulation of hydrolase activity|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp269|Bisphenol A 100μM R06 exp269]]|-2.33|
|[[:results:exp414|Tozasertib 0.1μM R07 exp414]]|-2.01|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4853
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.62 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PHACTR3 Expression in NALM6 Cells: 4.62'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>