PI4KA [The Human Chemical-Genetic Interaction Map Project]

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======= PI4KA =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PI4KA
  * **<color #00a2e8>Official Name</color>**: phosphatidylinositol 4-kinase alpha
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5297|5297]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P42356|P42356]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PI4KA&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PI4KA|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600286|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a phosphatidylinositol (PI) 4-kinase which catalyzes the first committed step in the biosynthesis of phosphatidylinositol 4,5-bisphosphate. The mammalian PI 4-kinases have been classified into two types, II and III, based on their molecular mass, and modulation by detergent and adenosine. The protein encoded by this gene is a type III enzyme that is not inhibited by adenosine. [provided by RefSeq, Sep 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Acts on phosphatidylinositol (PtdIns) in the first committed step in the production of the second messenger inositol- 1,4,5,-trisphosphate. {ECO:0000269|PubMed:10101268, ECO:0000269|PubMed:23229899}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PI3Ka|
|PI3 PI4 kinase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|viral replication complex formation and maintenance|
|viral replication complex|
|1-phosphatidylinositol 4-kinase activity|
|multi-organism membrane organization|
|viral RNA genome replication|
|Golgi-associated vesicle membrane|
|multi-organism cellular process|
|viral genome replication|
|phosphatidylinositol phosphorylation|
|lipid phosphorylation|
|phosphatidylinositol-mediated signaling|
|inositol lipid-mediated signaling|
|kinase activity|
|phosphatidylinositol biosynthetic process|
|phosphatidylinositol metabolic process|
|viral life cycle|
|lipid modification|
|glycerophospholipid biosynthetic process|
|glycerolipid biosynthetic process|
|phospholipid biosynthetic process|
|glycerophospholipid metabolic process|
|cadherin binding|
|phospholipid metabolic process|
|glycerolipid metabolic process|
|focal adhesion|
|organophosphate biosynthetic process|
|lipid biosynthetic process|
|viral process|
|symbiotic process|
|interspecies interaction between organisms|
|membrane organization|
|organophosphate metabolic process|
|cellular lipid metabolic process|
|lipid metabolic process|
|phosphorylation|
|ATP binding|
|intracellular signal transduction|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp78|Pterostilbene 16μM R02 exp78]]|-1.87|
|[[:results:exp270|Campthothecin 0.001μM R06 exp270]]|-1.72|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|-1.71|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|1.91|
|[[:results:exp475|CyclicAMP 200μM R08 exp475]]|1.96|
|[[:results:exp107|UMK57 0.6μM R03 exp107]]|2.13|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 464/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|16/28|
|blood|11/28|
|bone|16/26|
|breast|25/33|
|central nervous system|34/56|
|cervix|3/4|
|colorectal|13/17|
|esophagus|7/13|
|fibroblast|1/1|
|gastric|15/16|
|kidney|11/21|
|liver|11/20|
|lung|51/75|
|lymphocyte|11/16|
|ovary|22/26|
|pancreas|17/24|
|peripheral nervous system|6/16|
|plasma cell|8/15|
|prostate|0/1|
|skin|11/24|
|soft tissue|6/9|
|thyroid|1/2|
|upper aerodigestive|11/22|
|urinary tract|23/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1138
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.08 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PI4KA Expression in NALM6 Cells: 8.08'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>