PIK3C2B [The Human Chemical-Genetic Interaction Map Project]

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======= PIK3C2B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PIK3C2B
  * **<color #00a2e8>Official Name</color>**: phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5287|5287]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O00750|O00750]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PIK3C2B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PIK3C2B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602838|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Phosphorylates PtdIns and PtdIns4P with a preference for PtdIns. Does not phosphorylate PtdIns(4,5)P2. May be involved in EGF and PDGF signaling cascades. {ECO:0000269|PubMed:10805725}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PX|
|PI3Ka|
|C2|
|PI3K C2|
|PI3 PI4 kinase|
|PI3K rbd|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|lipid kinase activity|
|1-phosphatidylinositol-4-phosphate 3-kinase activity|
|1-phosphatidylinositol-3-kinase activity|
|phosphatidylinositol-3-phosphate biosynthetic process|
|phosphatidylinositol 3-kinase complex|
|phosphatidylinositol 3-kinase signaling|
|protein kinase B signaling|
|phosphatidylinositol phosphorylation|
|endocytic vesicle|
|autophagosome organization|
|lipid phosphorylation|
|phosphatidylinositol-mediated signaling|
|inositol lipid-mediated signaling|
|phosphatidylinositol binding|
|phosphatidylinositol biosynthetic process|
|vacuole organization|
|cellular response to starvation|
|macroautophagy|
|phosphatidylinositol metabolic process|
|response to starvation|
|lipid modification|
|glycerophospholipid biosynthetic process|
|glycerolipid biosynthetic process|
|cellular response to nutrient levels|
|phospholipid biosynthetic process|
|process utilizing autophagic mechanism|
|autophagy|
|cellular response to extracellular stimulus|
|glycerophospholipid metabolic process|
|cellular response to external stimulus|
|phospholipid metabolic process|
|glycerolipid metabolic process|
|response to nutrient levels|
|response to extracellular stimulus|
|organophosphate biosynthetic process|
|lipid biosynthetic process|
|organophosphate metabolic process|
|cellular lipid metabolic process|
|cell migration|
|endoplasmic reticulum|
|localization of cell|
|cell motility|
|lipid metabolic process|
|phosphorylation|
|locomotion|
|ATP binding|
|movement of cell or subcellular component|
|intracellular signal transduction|
|cellular response to stress|
|cellular catabolic process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|-1.95|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|-1.92|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|-1.82|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12485
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.36 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PIK3C2B Expression in NALM6 Cells: 6.36'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>