PIK3C2G [The Human Chemical-Genetic Interaction Map Project]

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======= PIK3C2G =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PIK3C2G
  * **<color #00a2e8>Official Name</color>**: phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5288|5288]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O75747|O75747]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PIK3C2G&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PIK3C2G|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609001|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. This gene may play a role in several diseases, including type II diabetes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Generates phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) that act as second messengers. May play a role in SDF1A-stimulated chemotaxis (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PI3K rbd|
|PI3 PI4 kinase|
|PI3K C2|
|PI3Ka|
|PX|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|phosphatidylinositol phosphate kinase activity|
|1-phosphatidylinositol-4-phosphate 3-kinase activity|
|1-phosphatidylinositol-3-kinase activity|
|viral RNA genome replication|
|phosphatidylinositol-3-phosphate biosynthetic process|
|phosphatidylinositol 3-kinase complex|
|viral genome replication|
|phosphatidylinositol 3-kinase signaling|
|phosphatidylinositol phosphorylation|
|lipid phosphorylation|
|phosphatidylinositol-mediated signaling|
|inositol lipid-mediated signaling|
|phosphatidylinositol binding|
|phosphatidylinositol biosynthetic process|
|phosphatidylinositol metabolic process|
|viral life cycle|
|lipid modification|
|glycerophospholipid biosynthetic process|
|glycerolipid biosynthetic process|
|phospholipid biosynthetic process|
|glycerophospholipid metabolic process|
|phospholipid metabolic process|
|glycerolipid metabolic process|
|organophosphate biosynthetic process|
|chemotaxis|
|taxis|
|lipid biosynthetic process|
|viral process|
|symbiotic process|
|interspecies interaction between organisms|
|organophosphate metabolic process|
|cellular lipid metabolic process|
|cell migration|
|localization of cell|
|cell motility|
|lipid metabolic process|
|phosphorylation|
|locomotion|
|ATP binding|
|movement of cell or subcellular component|
|intracellular signal transduction|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp120|Dimethyl-Sulfoxide 1pc R03 exp120]]|1.95|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14564
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.76 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PIK3C2G Expression in NALM6 Cells: -1.76'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>