PIK3R5 [The Human Chemical-Genetic Interaction Map Project]

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======= PIK3R5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PIK3R5
  * **<color #00a2e8>Official Name</color>**: phosphoinositide-3-kinase regulatory subunit 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23533|23533]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8WYR1|Q8WYR1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PIK3R5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PIK3R5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611317|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Phosphatidylinositol 3-kinases (PI3Ks) phosphorylate the inositol ring of phosphatidylinositol at the 3-prime position, and play important roles in cell growth, proliferation, differentiation, motility, survival and intracellular trafficking. The PI3Ks are divided into three classes: I, II and III, and only the class I PI3Ks are involved in oncogenesis. This gene encodes the 101 kD regulatory subunit of the class I PI3K gamma complex, which is a dimeric enzyme, consisting of a 110 kD catalytic subunit gamma and a regulatory subunit of either 55, 87 or 101 kD. This protein recruits the catalytic subunit from the cytosol to the plasma membrane through high-affinity interaction with G-beta-gamma proteins. Multiple alternatively spliced transcript variants encoding two distinct isoforms have been found. [provided by RefSeq, Oct 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Regulatory subunit of the PI3K gamma complex. Required for recruitment of the catalytic subunit to the plasma membrane via interaction with beta-gamma G protein dimers. Required for G protein-mediated activation of PIK3CG (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PI3K 1B p101|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|phosphatidylinositol 3-kinase complex, class IB|
|1-phosphatidylinositol-3-kinase regulator activity|
|phosphatidylinositol 3-kinase complex|
|G-protein beta/gamma-subunit complex binding|
|phosphatidylinositol 3-kinase signaling|
|regulation of phosphatidylinositol 3-kinase activity|
|regulation of lipid kinase activity|
|phosphatidylinositol-mediated signaling|
|inositol lipid-mediated signaling|
|regulation of phospholipid metabolic process|
|positive regulation of phosphatidylinositol 3-kinase signaling|
|phosphatidylinositol biosynthetic process|
|regulation of phosphatidylinositol 3-kinase signaling|
|platelet activation|
|microtubule organizing center|
|positive regulation of protein kinase B signaling|
|phosphatidylinositol metabolic process|
|glycerophospholipid biosynthetic process|
|regulation of protein kinase B signaling|
|glycerolipid biosynthetic process|
|phospholipid biosynthetic process|
|positive regulation of MAP kinase activity|
|blood coagulation|
|coagulation|
|hemostasis|
|glycerophospholipid metabolic process|
|positive regulation of protein serine/threonine kinase activity|
|regulation of MAP kinase activity|
|phospholipid metabolic process|
|glycerolipid metabolic process|
|regulation of lipid metabolic process|
|wound healing|
|regulation of body fluid levels|
|regulation of protein serine/threonine kinase activity|
|positive regulation of protein kinase activity|
|organophosphate biosynthetic process|
|positive regulation of MAPK cascade|
|response to wounding|
|positive regulation of kinase activity|
|lipid biosynthetic process|
|positive regulation of transferase activity|
|regulation of MAPK cascade|
|regulation of protein kinase activity|
|regulation of kinase activity|
|organophosphate metabolic process|
|cellular lipid metabolic process|
|regulation of transferase activity|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|positive regulation of phosphorylation|
|cell activation|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|lipid metabolic process|
|positive regulation of protein modification process|
|G protein-coupled receptor signaling pathway|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|positive regulation of signal transduction|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|-1.72|
|[[:results:exp347|Cyclosporin-A 0.8μM R07 exp347]]|2.19|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4293
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.36 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PIK3R5 Expression in NALM6 Cells: 0.36'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>