PKD1L2 [The Human Chemical-Genetic Interaction Map Project]

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======= PKD1L2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PKD1L2
  * **<color #00a2e8>Official Name</color>**: polycystin 1 like 2 (gene/pseudogene)
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=114780|114780]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q7Z442|Q7Z442]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PKD1L2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PKD1L2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607894|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the polycystin protein family. The encoded protein contains 11 transmembrane domains, a latrophilin/CL-1-like GPCR proteolytic site (GPS) domain, and a polycystin-1, lipoxygenase, alpha-toxin (PLAT) domain. This protein may function as a component of cation channel pores. This gene appears to be a polymorphic pseudogene in humans, where some individuals contain a non-functional allele. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**:  May function as an ion-channel regulator. May function as a G-protein-coupled receptor. {ECO:0000269|PubMed:15203210}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Lectin C|
|Gal Lectin|
|REJ|
|PLAT|
|PKD channel|
|GPS|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|detection of mechanical stimulus|
|calcium channel activity|
|detection of external stimulus|
|detection of abiotic stimulus|
|carbohydrate binding|
|calcium ion transmembrane transport|
|response to mechanical stimulus|
|calcium ion transport|
|divalent metal ion transport|
|divalent inorganic cation transport|
|inorganic cation transmembrane transport|
|cation transmembrane transport|
|metal ion transport|
|inorganic ion transmembrane transport|
|detection of stimulus|
|calcium ion binding|
|cation transport|
|ion transmembrane transport|
|response to abiotic stimulus|
|transmembrane transport|
|ion transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp54|Taxol 0.002μM R01 exp54]]|1.97|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: N/A
^Tissue^Fraction Of Cell Lines Where Essential^
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17750
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.75 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PKD1L2 Expression in NALM6 Cells: 3.75'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>