PKD2L1 [The Human Chemical-Genetic Interaction Map Project]

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======= PKD2L1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PKD2L1
  * **<color #00a2e8>Official Name</color>**: polycystin 2 like 1, transient receptor potential cation channel
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9033|9033]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9P0L9|Q9P0L9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PKD2L1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PKD2L1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604532|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the polycystin protein family. The encoded protein contains multiple transmembrane domains, and cytoplasmic N- and C-termini. The protein may be an integral membrane protein involved in cell-cell/matrix interactions. This protein functions as a calcium-regulated nonselective cation channel. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Pore-forming subunit of a ciliary calcium channel that controls calcium concentration within primary cilia without affecting cytoplasmic calcium concentration. Forms a heterodimer with PKD1L1 in primary cilia and forms a calcium-permeant ciliary channel that regulates sonic hedgehog/SHH signaling and GLI2 transcription. May act as a sour taste receptor by forming a calcium channel with PKD1L3 in gustatory cells; however, its contribution to sour taste perception is unclear in vivo and may be indirect. {ECO:0000269|PubMed:10517637, ECO:0000269|PubMed:19812697, ECO:0000269|PubMed:23212381, ECO:0000269|PubMed:24336289}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ion trans|
|PKD channel|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|sour taste receptor activity|
|detection of chemical stimulus involved in sensory perception of sour taste|
|sensory perception of sour taste|
|cation transmembrane transporter activity|
|sodium channel activity|
|cellular response to acidic pH|
|calcium activated cation channel activity|
|calcium-activated potassium channel activity|
|response to water|
|alpha-actinin binding|
|cation channel activity|
|cellular response to pH|
|muscle alpha-actinin binding|
|response to acidic pH|
|calcium channel complex|
|non-motile cilium|
|response to pH|
|detection of mechanical stimulus|
|detection of chemical stimulus involved in sensory perception of taste|
|calcium channel activity|
|ciliary membrane|
|sensory perception of taste|
|smoothened signaling pathway|
|cytoskeletal protein binding|
|sodium ion transmembrane transport|
|protein homotetramerization|
|detection of external stimulus|
|detection of abiotic stimulus|
|protein tetramerization|
|sodium ion transport|
|potassium ion transmembrane transport|
|potassium ion transport|
|calcium ion transmembrane transport|
|receptor complex|
|response to mechanical stimulus|
|calcium ion transport|
|cytoplasmic vesicle|
|divalent metal ion transport|
|divalent inorganic cation transport|
|cellular response to abiotic stimulus|
|cellular response to environmental stimulus|
|protein homooligomerization|
|response to acid chemical|
|monovalent inorganic cation transport|
|detection of chemical stimulus involved in sensory perception|
|protein complex oligomerization|
|detection of chemical stimulus|
|response to inorganic substance|
|sensory perception of chemical stimulus|
|detection of stimulus involved in sensory perception|
|inorganic cation transmembrane transport|
|cation transmembrane transport|
|cell surface|
|metal ion transport|
|inorganic ion transmembrane transport|
|intracellular membrane-bounded organelle|
|detection of stimulus|
|calcium ion binding|
|cation transport|
|ion transmembrane transport|
|sensory perception|
|endoplasmic reticulum|
|identical protein binding|
|response to abiotic stimulus|
|transmembrane transport|
|ion transport|
|nervous system process|
|integral component of plasma membrane|
|response to oxygen-containing compound|
|protein-containing complex assembly|
|protein-containing complex subunit organization|
|system process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp115|A-366 10μM R03 exp115]]|1.96|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7260
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -4.6 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PKD2L1 Expression in NALM6 Cells: -4.6'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>