PLA2G4E [The Human Chemical-Genetic Interaction Map Project]

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======= PLA2G4E =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PLA2G4E
  * **<color #00a2e8>Official Name</color>**: phospholipase A2 group IVE
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=123745|123745]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q3MJ16|Q3MJ16]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PLA2G4E&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PLA2G4E|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/620649|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the cytosolic phospholipase A2 group IV family. Members of this family are involved in regulation of membrane tubule-mediated transport. The enzyme encoded by this member of the family plays a role in trafficking through the clathrin-independent endocytic pathway. The enzyme regulates the recycling process via formation of tubules that transport internalized clathrin-independent cargo proteins back to the cell surface. [provided by RefSeq, Jan 2017]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Calcium-dependent phospholipase A2 that selectively hydrolyzes glycerophospholipids in the sn-2 position. {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PLA2 B|
|C2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|calcium-dependent phospholipase A2 activity|
|phosphatidylinositol acyl-chain remodeling|
|glycerophospholipid catabolic process|
|phosphatidylserine acyl-chain remodeling|
|phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine)|
|phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine)|
|phosphatidylethanolamine acyl-chain remodeling|
|phosphatidylcholine acyl-chain remodeling|
|phospholipase A2 activity|
|phosphatidylserine metabolic process|
|phospholipid catabolic process|
|glycerolipid catabolic process|
|calcium-dependent phospholipid binding|
|phosphatidylcholine metabolic process|
|organophosphate catabolic process|
|phosphatidylinositol metabolic process|
|ammonium ion metabolic process|
|cellular lipid catabolic process|
|cellular modified amino acid metabolic process|
|lipid catabolic process|
|lysosomal membrane|
|glycerophospholipid metabolic process|
|phospholipid metabolic process|
|glycerolipid metabolic process|
|calcium ion binding|
|organophosphate metabolic process|
|cellular lipid metabolic process|
|lipid metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp495|IWR1 50μM R08 exp495]]|-2.14|
|[[:results:exp124|GSK343 3μM R03 exp124]]|-1.97|
|[[:results:exp5|Alpha-Amanitin 0.5μM R00 exp5]]|-1.85|
|[[:results:exp120|Dimethyl-Sulfoxide 1pc R03 exp120]]|-1.76|
|[[:results:exp422|Wiskostatin 3μM R07 exp422]]|-1.71|
|[[:results:exp513|ONC212 0.15μM R08 exp513]]|1.7|
|[[:results:exp358|FK-506 5μM R07 exp358]]|1.83|
|[[:results:exp53|Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53]]|2.35|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3609
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.05 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PLA2G4E Expression in NALM6 Cells: 1.05'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>