PLA2G4F [The Human Chemical-Genetic Interaction Map Project]

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======= PLA2G4F =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PLA2G4F
  * **<color #00a2e8>Official Name</color>**: phospholipase A2 group IVF
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=255189|255189]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q68DD2|Q68DD2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PLA2G4F&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PLA2G4F|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**:  N/A

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Calcium-dependent phospholipase A2 that selectively hydrolyzes glycerophospholipids in the sn-2 position. Has higher enzyme activity for phosphatidylethanolamine than phosphatidylcholine (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PLA2 B|
|C2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|calcium-dependent phospholipase A2 activity|
|phosphatidylinositol acyl-chain remodeling|
|phosphatidylglycerol acyl-chain remodeling|
|prostanoid biosynthetic process|
|prostaglandin biosynthetic process|
|glycerophospholipid catabolic process|
|lysophospholipase activity|
|phosphatidylserine acyl-chain remodeling|
|arachidonate transport|
|arachidonic acid secretion|
|phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine)|
|phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine)|
|phosphatidylethanolamine acyl-chain remodeling|
|phosphatidylcholine acyl-chain remodeling|
|icosanoid secretion|
|phospholipase A2 activity|
|phosphatidylglycerol metabolic process|
|icosanoid transport|
|phosphatidylserine metabolic process|
|fatty acid derivative transport|
|prostanoid metabolic process|
|prostaglandin metabolic process|
|phospholipid catabolic process|
|unsaturated fatty acid biosynthetic process|
|icosanoid biosynthetic process|
|glycerolipid catabolic process|
|calcium-dependent phospholipid binding|
|long-chain fatty acid transport|
|fatty acid transport|
|phosphatidylcholine metabolic process|
|acid secretion|
|fatty acid derivative biosynthetic process|
|ruffle membrane|
|unsaturated fatty acid metabolic process|
|icosanoid metabolic process|
|cellular response to antibiotic|
|fatty acid biosynthetic process|
|organophosphate catabolic process|
|monocarboxylic acid transport|
|vesicle|
|fatty acid derivative metabolic process|
|phosphatidylinositol metabolic process|
|monocarboxylic acid biosynthetic process|
|ammonium ion metabolic process|
|cellular lipid catabolic process|
|cellular modified amino acid metabolic process|
|carboxylic acid transport|
|organic acid transport|
|lipid transport|
|lipid catabolic process|
|lysosomal membrane|
|carboxylic acid biosynthetic process|
|organic acid biosynthetic process|
|response to antibiotic|
|glycerophospholipid metabolic process|
|lipid localization|
|fatty acid metabolic process|
|phospholipid metabolic process|
|glycerolipid metabolic process|
|organic anion transport|
|monocarboxylic acid metabolic process|
|cellular response to organic cyclic compound|
|lipid biosynthetic process|
|anion transport|
|small molecule biosynthetic process|
|calcium ion binding|
|organophosphate metabolic process|
|carboxylic acid metabolic process|
|response to organic cyclic compound|
|cellular lipid metabolic process|
|oxoacid metabolic process|
|organic acid metabolic process|
|secretion|
|lipid metabolic process|
|ion transport|
|small molecule metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.635|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.487|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.486|
|[[:human genes:a:acsf2|ACSF2]]|0.475|
|[[:human genes:r:rps12|RPS12]]|0.475|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.468|
|[[:human genes:m:myo1h|MYO1H]]|0.465|
|[[:human genes:d:dtl|DTL]]|0.465|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.465|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.46|
|[[:human genes:c:c14orf93|C14orf93]]|0.458|
|[[:human genes:a:akirin2|AKIRIN2]]|0.458|
|[[:human genes:t:tceb3c|TCEB3C]]|0.455|
|[[:human genes:c:cdc6|CDC6]]|0.454|
|[[:human genes:c:cwc15|CWC15]]|0.451|
|[[:human genes:m:mt1e|MT1E]]|0.451|
|[[:human genes:p:psmd2|PSMD2]]|0.45|
|[[:human genes:t:tfip11|TFIP11]]|0.449|
|[[:human genes:r:rrn3|RRN3]]|0.449|
|[[:human genes:d:ddx56|DDX56]]|0.447|
|[[:human genes:p:psmb2|PSMB2]]|0.447|
|[[:human genes:o:orc6|ORC6]]|0.445|
|[[:human genes:a:ankle1|ANKLE1]]|0.44|
|[[:human genes:l:lrr1|LRR1]]|0.435|
|[[:human genes:u:utp3|UTP3]]|0.435|
|[[:human genes:s:s1pr4|S1PR4]]|0.433|
|[[:human genes:s:sec13|SEC13]]|0.433|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.432|
|[[:human genes:c:cbwd3|CBWD3]]|0.431|
|[[:human genes:r:rps2|RPS2]]|0.43|
|[[:human genes:g:golga6b|GOLGA6B]]|0.43|
|[[:human genes:t:twistnb|TWISTNB]]|0.429|
|[[:human genes:d:ddtl|DDTL]]|0.429|
|[[:human genes:c:ctage4|CTAGE4]]|0.428|
|[[:human genes:r:rpl6|RPL6]]|0.424|
|[[:human genes:r:ranbp2|RANBP2]]|0.423|
|[[:human genes:s:snrpa1|SNRPA1]]|0.423|
|[[:human genes:c:cbwd5|CBWD5]]|0.423|
|[[:human genes:r:rfxank|RFXANK]]|0.422|
|[[:human genes:v:vasn|VASN]]|0.422|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.42|
|[[:human genes:r:rps3a|RPS3A]]|0.42|
|[[:human genes:t:tspy1|TSPY1]]|0.419|
|[[:human genes:c:c2orf27b|C2orf27B]]|0.419|
|[[:human genes:n:narfl|NARFL]]|0.419|
|[[:human genes:t:tspy2|TSPY2]]|0.419|
|[[:human genes:c:csnk1a1|CSNK1A1]]|0.418|
|[[:human genes:r:rpl35|RPL35]]|0.417|
|[[:human genes:c:cdc45|CDC45]]|0.416|
|[[:human genes:r:rps5|RPS5]]|0.414|
|[[:human genes:c:ccna2|CCNA2]]|0.414|
|[[:human genes:c:cbwd6|CBWD6]]|0.413|
|[[:human genes:z:znf219|ZNF219]]|0.413|
|[[:human genes:h:hist1h2be|HIST1H2BE]]|0.412|
|[[:human genes:c:cdc73|CDC73]]|0.412|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.411|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.411|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.411|
|[[:human genes:n:nup54|NUP54]]|0.411|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.411|
|[[:human genes:r:rps14|RPS14]]|0.41|
|[[:human genes:e:eif3g|EIF3G]]|0.41|
|[[:human genes:p:psmd11|PSMD11]]|0.409|
|[[:human genes:r:rps19|RPS19]]|0.409|
|[[:human genes:p:psmc1|PSMC1]]|0.409|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.409|
|[[:human genes:a:arhgef35|ARHGEF35]]|0.409|
|[[:human genes:p:psmd6|PSMD6]]|0.407|
|[[:human genes:h:hap1|HAP1]]|0.405|
|[[:human genes:p:pold1|POLD1]]|0.404|
|[[:human genes:p:polr2f|POLR2F]]|0.403|
|[[:human genes:a:atp6v1c1|ATP6V1C1]]|0.403|
|[[:human genes:t:tspy8|TSPY8]]|0.402|
|[[:human genes:c:ccdc116|CCDC116]]|0.402|
|[[:human genes:w:wdr87|WDR87]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2091
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.03 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PLA2G4F Expression in NALM6 Cells: -0.03'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>