PLA2R1 [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= PLA2R1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PLA2R1
  * **<color #00a2e8>Official Name</color>**: phospholipase A2 receptor 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=22925|22925]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q13018|Q13018]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PLA2R1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PLA2R1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604939|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Receptor for secretory phospholipase A2 (sPLA2). Acts as a receptor for phosholipase sPLA2-IB/PLA2G1B but not sPLA2- IIA/PLA2G2A. Also able to bind to snake PA2-like toxins. Although its precise function remains unclear, binding of sPLA2 to its receptor participates in both positive and negative regulation of sPLA2 functions as well as clearance of sPLA2. Binding of sPLA2- IB/PLA2G1B induces various effects depending on the cell type, such as activation of the mitogen-activated protein kinase (MAPK) cascade to induce cell proliferation, the production of lipid mediators, selective release of arachidonic acid in bone marrow- derived mast cells. In neutrophils, binding of sPLA2-IB/PLA2G1B can activate p38 MAPK to stimulate elastase release and cell adhesion. May be involved in responses in proinflammatory cytokine productions during endotoxic shock. Also has endocytic properties and rapidly internalizes sPLA2 ligands, which is particularly important for the clearance of extracellular sPLA2s to protect their potent enzymatic activities. The soluble secretory phospholipase A2 receptor form is circulating and acts as a negative regulator of sPLA2 functions by blocking the biological functions of sPLA2-IB/PLA2G1B. {ECO:0000269|PubMed:15611272, ECO:0000269|PubMed:7721806}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|fn2|
|Lectin C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of arachidonic acid secretion|
|oxidative stress-induced premature senescence|
|negative regulation of icosanoid secretion|
|negative regulation of phospholipase A2 activity|
|positive regulation of arachidonic acid secretion|
|stress-induced premature senescence|
|regulation of arachidonic acid secretion|
|negative regulation of fatty acid transport|
|negative regulation of phospholipase activity|
|replicative senescence|
|regulation of phospholipase A2 activity|
|positive regulation of DNA damage response, signal transduction by p53 class mediator|
|phospholipase binding|
|positive regulation of icosanoid secretion|
|negative regulation of lipase activity|
|positive regulation of fatty acid transport|
|regulation of icosanoid secretion|
|negative regulation of organic acid transport|
|positive regulation of signal transduction by p53 class mediator|
|negative regulation of lipid transport|
|regulation of fatty acid transport|
|negative regulation of anion transport|
|cellular senescence|
|positive regulation of organic acid transport|
|regulation of DNA damage response, signal transduction by p53 class mediator|
|negative regulation of lipid localization|
|positive regulation of anion transport|
|regulation of organic acid transport|
|positive regulation of lipid transport|
|cell aging|
|regulation of phospholipase activity|
|positive regulation of lipid localization|
|regulation of anion transport|
|regulation of lipase activity|
|positive regulation of response to DNA damage stimulus|
|regulation of lipid transport|
|reactive oxygen species metabolic process|
|transmembrane signaling receptor activity|
|regulation of lipid localization|
|negative regulation of ion transport|
|cytokine production|
|carbohydrate binding|
|regulation of signal transduction by p53 class mediator|
|receptor complex|
|regulation of response to DNA damage stimulus|
|negative regulation of secretion|
|receptor-mediated endocytosis|
|cellular response to oxidative stress|
|positive regulation of ion transport|
|aging|
|response to oxidative stress|
|positive regulation of secretion|
|negative regulation of hydrolase activity|
|negative regulation of transport|
|endocytosis|
|cell surface|
|import into cell|
|regulation of ion transport|
|regulation of cellular response to stress|
|negative regulation of catalytic activity|
|regulation of secretion|
|positive regulation of transport|
|positive regulation of intracellular signal transduction|
|negative regulation of molecular function|
|regulation of hydrolase activity|
|regulation of response to stress|
|positive regulation of signal transduction|
|cellular response to stress|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of transport|
|extracellular region|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|1.75|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9130
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.5 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PLA2R1 Expression in NALM6 Cells: 1.5'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>