PLCB1 [The Human Chemical-Genetic Interaction Map Project]

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======= PLCB1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PLCB1
  * **<color #00a2e8>Official Name</color>**: phospholipase C beta 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23236|23236]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NQ66|Q9NQ66]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PLCB1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PLCB1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607120|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals. This gene is activated by two G-protein alpha subunits, alpha-q and alpha-11. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PLC-beta C|
|efhand like|
|PI-PLC-Y|
|PI-PLC-X|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of CD24 biosynthetic process|
|negative regulation of monocyte extravasation|
|regulation of CD24 biosynthetic process|
|activation of meiosis involved in egg activation|
|regulation of retrograde trans-synaptic signaling by endocanabinoid|
|activation of meiosis|
|regulation of monocyte extravasation|
|egg activation|
|negative regulation of mononuclear cell migration|
|negative regulation of cellular extravasation|
|phospholipase C activity|
|positive regulation of acrosome reaction|
|insulin-like growth factor receptor signaling pathway|
|interleukin-15-mediated signaling pathway|
|cellular response to interleukin-15|
|positive regulation of fertilization|
|response to interleukin-15|
|positive regulation of meiotic nuclear division|
|lamin binding|
|inositol trisphosphate biosynthetic process|
|postsynaptic modulation of chemical synaptic transmission|
|G protein-coupled acetylcholine receptor signaling pathway|
|inositol trisphosphate metabolic process|
|regulation of acrosome reaction|
|positive regulation of glycoprotein biosynthetic process|
|positive regulation of glycoprotein metabolic process|
|positive regulation of myoblast differentiation|
|positive regulation of meiotic cell cycle|
|phosphatidylinositol phospholipase C activity|
|inositol phosphate biosynthetic process|
|regulation of fertilization|
|regulation of cellular extravasation|
|acetylcholine receptor signaling pathway|
|regulation of meiotic nuclear division|
|cellular response to acetylcholine|
|response to acetylcholine|
|positive regulation of interleukin-12 production|
|positive regulation of G1/S transition of mitotic cell cycle|
|positive regulation of embryonic development|
|Wnt signaling pathway, calcium modulating pathway|
|postsynaptic signal transduction|
|regulation of glycoprotein biosynthetic process|
|glutamate receptor signaling pathway|
|regulation of glycoprotein metabolic process|
|negative regulation of leukocyte migration|
|regulation of mononuclear cell migration|
|interleukin-12-mediated signaling pathway|
|positive regulation of cell cycle G1/S phase transition|
|cellular response to interleukin-12|
|response to interleukin-12|
|regulation of meiotic cell cycle|
|regulation of myoblast differentiation|
|regulation of interleukin-12 production|
|release of sequestered calcium ion into cytosol|
|negative regulation of sequestering of calcium ion|
|inositol phosphate metabolic process|
|polyol biosynthetic process|
|positive regulation of nuclear division|
|GABA-ergic synapse|
|calcium ion transmembrane import into cytosol|
|phosphatidylinositol-mediated signaling|
|calcium ion transport into cytosol|
|inositol lipid-mediated signaling|
|phosphatidylinositol-4,5-bisphosphate binding|
|positive regulation of mitotic cell cycle phase transition|
|positive regulation of reproductive process|
|postsynapse|
|cytosolic calcium ion transport|
|signal transduction involved in cellular response to ammonium ion|
|positive regulation of cell cycle phase transition|
|interleukin-1-mediated signaling pathway|
|fat cell differentiation|
|polyol metabolic process|
|alcohol biosynthetic process|
|cerebral cortex development|
|memory|
|regulation of sequestering of calcium ion|
|regulation of embryonic development|
|cellular response to ammonium ion|
|G2/M transition of mitotic cell cycle|
|cell cycle G2/M phase transition|
|non-canonical Wnt signaling pathway|
|positive regulation of JNK cascade|
|single fertilization|
|regulation of G protein-coupled receptor signaling pathway|
|regulation of G1/S transition of mitotic cell cycle|
|positive regulation of mitotic cell cycle|
|regulation of reproductive process|
|regulation of cell cycle G1/S phase transition|
|positive regulation of stress-activated MAPK cascade|
|phosphatidylinositol metabolic process|
|positive regulation of stress-activated protein kinase signaling cascade|
|fertilization|
|positive regulation of developmental growth|
|pallium development|
|cellular response to interleukin-1|
|response to ammonium ion|
|regulation of JNK cascade|
|organic hydroxy compound biosynthetic process|
|regulation of nuclear division|
|regulation of leukocyte migration|
|calcium ion transmembrane transport|
|response to interleukin-1|
|calmodulin binding|
|regulation of stress-activated MAPK cascade|
|regulation of stress-activated protein kinase signaling cascade|
|nuclear chromatin|
|nuclear membrane|
|calcium ion transport|
|telencephalon development|
|negative regulation of cell migration|
|positive regulation of growth|
|learning or memory|
|mitotic cell cycle phase transition|
|negative regulation of cell motility|
|cell cycle phase transition|
|GTPase activator activity|
|positive regulation of cytosolic calcium ion concentration|
|positive regulation of cell cycle process|
|divalent metal ion transport|
|lipid catabolic process|
|cognition|
|divalent inorganic cation transport|
|glycerophospholipid metabolic process|
|negative regulation of cellular component movement|
|alcohol metabolic process|
|negative regulation of locomotion|
|regulation of cytosolic calcium ion concentration|
|regulation of developmental growth|
|glutamatergic synapse|
|enzyme binding|
|Wnt signaling pathway|
|cell-cell signaling by wnt|
|phospholipid metabolic process|
|positive regulation of cell cycle|
|glycerolipid metabolic process|
|forebrain development|
|nuclear speck|
|cellular response to drug|
|regulation of mitotic cell cycle phase transition|
|positive regulation of GTPase activity|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|cellular calcium ion homeostasis|
|modulation of chemical synaptic transmission|
|negative regulation of immune system process|
|regulation of trans-synaptic signaling|
|regulation of cell cycle phase transition|
|positive regulation of cytokine production|
|calcium ion homeostasis|
|organic hydroxy compound metabolic process|
|synaptic signaling|
|cellular divalent inorganic cation homeostasis|
|regulation of GTPase activity|
|divalent inorganic cation homeostasis|
|positive regulation of multi-organism process|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|organophosphate biosynthetic process|
|positive regulation of MAPK cascade|
|cellular metal ion homeostasis|
|inorganic cation transmembrane transport|
|behavior|
|small molecule biosynthetic process|
|protein-containing complex|
|mitotic cell cycle process|
|cellular response to hormone stimulus|
|cation transmembrane transport|
|positive regulation of organelle organization|
|metal ion homeostasis|
|regulation of mitotic cell cycle|
|cellular cation homeostasis|
|metal ion transport|
|cellular ion homeostasis|
|inorganic ion transmembrane transport|
|cellular response to nitrogen compound|
|regulation of growth|
|cytokine-mediated signaling pathway|
|mitotic cell cycle|
|regulation of cytokine production|
|cation homeostasis|
|enzyme linked receptor protein signaling pathway|
|inorganic ion homeostasis|
|calcium ion binding|
|regulation of cellular response to stress|
|brain development|
|cellular chemical homeostasis|
|regulation of cell cycle process|
|regulation of MAPK cascade|
|positive regulation of hydrolase activity|
|regulation of multi-organism process|
|head development|
|ion homeostasis|
|cation transport|
|sexual reproduction|
|regulation of cell migration|
|protein homodimerization activity|
|organophosphate metabolic process|
|cellular homeostasis|
|response to hormone|
|regulation of cell motility|
|ion transmembrane transport|
|cellular lipid metabolic process|
|positive regulation of cell differentiation|
|central nervous system development|
|regulation of locomotion|
|regulation of cellular component movement|
|multi-organism reproductive process|
|cell cycle process|
|cellular response to cytokine stimulus|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|response to drug|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|cell activation|
|response to nitrogen compound|
|response to cytokine|
|chemical homeostasis|
|cell-cell signaling|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|regulation of cell cycle|
|negative regulation of transcription, DNA-templated|
|positive regulation of cellular component organization|
|lipid metabolic process|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|transmembrane transport|
|regulation of hydrolase activity|
|regulation of organelle organization|
|G protein-coupled receptor signaling pathway|
|negative regulation of RNA metabolic process|
|cell cycle|
|positive regulation of developmental process|
|ion transport|
|nervous system process|
|negative regulation of cellular macromolecule biosynthetic process|
|reproductive process|
|reproduction|
|positive regulation of catalytic activity|
|negative regulation of nucleobase-containing compound metabolic process|
|regulation of protein phosphorylation|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|regulation of response to stress|
|negative regulation of cellular biosynthetic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|response to oxygen-containing compound|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|homeostatic process|
|positive regulation of signal transduction|
|regulation of immune system process|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|small molecule metabolic process|
|organic substance catabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|establishment of localization in cell|
|regulation of protein modification process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|system process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15631
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.67 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PLCB1 Expression in NALM6 Cells: 4.67'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>