PLCE1 [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= PLCE1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PLCE1
  * **<color #00a2e8>Official Name</color>**: phospholipase C epsilon 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51196|51196]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9P212|Q9P212]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PLCE1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PLCE1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608414|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a phospholipase enzyme that catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate to generate two second messengers: inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG). These second messengers subsequently regulate various processes affecting cell growth, differentiation, and gene expression. This enzyme is regulated by small monomeric GTPases of the Ras and Rho families and by heterotrimeric G proteins. In addition to its phospholipase C catalytic activity, this enzyme has an N-terminal domain with guanine nucleotide exchange (GEF) activity. Mutations in this gene cause early-onset nephrotic syndrome; characterized by proteinuria, edema, and diffuse mesangial sclerosis or focal and segmental glomerulosclerosis. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Sep 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RasGEF|
|RA|
|efhand like|
|PI-PLC-X|
|C2|
|PI-PLC-Y|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|diacylglycerol biosynthetic process|
|phospholipase C activity|
|Ras GTPase binding|
|inositol trisphosphate biosynthetic process|
|inositol trisphosphate metabolic process|
|neutral lipid biosynthetic process|
|acylglycerol biosynthetic process|
|diacylglycerol metabolic process|
|inositol phosphate-mediated signaling|
|phosphatidylinositol phospholipase C activity|
|inositol phosphate biosynthetic process|
|epidermal growth factor receptor signaling pathway|
|glomerulus development|
|release of sequestered calcium ion into cytosol|
|negative regulation of sequestering of calcium ion|
|inositol phosphate metabolic process|
|polyol biosynthetic process|
|regulation of smooth muscle contraction|
|calcium ion transmembrane import into cytosol|
|ERBB signaling pathway|
|phosphatidylinositol-mediated signaling|
|calcium ion transport into cytosol|
|inositol lipid-mediated signaling|
|cytosolic calcium ion transport|
|phospholipase C-activating G protein-coupled receptor signaling pathway|
|acylglycerol metabolic process|
|neutral lipid metabolic process|
|guanyl-nucleotide exchange factor activity|
|polyol metabolic process|
|alcohol biosynthetic process|
|regulation of sequestering of calcium ion|
|nephron development|
|regulation of G protein-coupled receptor signaling pathway|
|calcium-mediated signaling|
|activation of MAPK activity|
|regulation of muscle contraction|
|organic hydroxy compound biosynthetic process|
|calcium ion transmembrane transport|
|glycerolipid biosynthetic process|
|regulation of muscle system process|
|regulation of Ras protein signal transduction|
|Ras protein signal transduction|
|calcium ion transport|
|positive regulation of MAP kinase activity|
|kidney development|
|positive regulation of cytosolic calcium ion concentration|
|renal system development|
|divalent metal ion transport|
|lipid catabolic process|
|divalent inorganic cation transport|
|alcohol metabolic process|
|urogenital system development|
|small GTPase mediated signal transduction|
|regulation of cytosolic calcium ion concentration|
|activation of protein kinase activity|
|second-messenger-mediated signaling|
|positive regulation of protein serine/threonine kinase activity|
|regulation of MAP kinase activity|
|regulation of small GTPase mediated signal transduction|
|enzyme binding|
|glycerolipid metabolic process|
|regulation of cell growth|
|cellular calcium ion homeostasis|
|calcium ion homeostasis|
|organic hydroxy compound metabolic process|
|cellular divalent inorganic cation homeostasis|
|divalent inorganic cation homeostasis|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|regulation of protein serine/threonine kinase activity|
|heart development|
|positive regulation of protein kinase activity|
|organophosphate biosynthetic process|
|positive regulation of MAPK cascade|
|cell population proliferation|
|cellular metal ion homeostasis|
|inorganic cation transmembrane transport|
|positive regulation of kinase activity|
|lipid biosynthetic process|
|small molecule biosynthetic process|
|regulation of system process|
|cation transmembrane transport|
|Golgi membrane|
|metal ion homeostasis|
|cellular cation homeostasis|
|metal ion transport|
|cellular ion homeostasis|
|inorganic ion transmembrane transport|
|positive regulation of transferase activity|
|regulation of growth|
|cation homeostasis|
|enzyme linked receptor protein signaling pathway|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|regulation of MAPK cascade|
|ion homeostasis|
|regulation of protein kinase activity|
|cation transport|
|circulatory system development|
|regulation of kinase activity|
|organophosphate metabolic process|
|cellular homeostasis|
|ion transmembrane transport|
|cellular lipid metabolic process|
|regulation of transferase activity|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|positive regulation of phosphorylation|
|cytoskeleton organization|
|chemical homeostasis|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|lipid metabolic process|
|positive regulation of protein modification process|
|transmembrane transport|
|G protein-coupled receptor signaling pathway|
|ion transport|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|homeostatic process|
|positive regulation of signal transduction|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|small molecule metabolic process|
|organic substance catabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|establishment of localization in cell|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp11|CCCP 1μM R00 exp11]]|-1.71|
|[[:results:exp393|Resminostat 0.5μM R07 exp393]]|1.79|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|2.11|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7065
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.39 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PLCE1 Expression in NALM6 Cells: 4.39'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>