PLEK [The Human Chemical-Genetic Interaction Map Project]

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======= PLEK =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PLEK
  * **<color #00a2e8>Official Name</color>**: pleckstrin
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5341|5341]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P08567|P08567]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PLEK&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PLEK|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/173570|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Major protein kinase C substrate of platelets.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DEP|
|PH|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of inositol-polyphosphate 5-phosphatase activity|
|phospholipase C-inhibiting G protein-coupled receptor signaling pathway|
|negative regulation of inositol phosphate biosynthetic process|
|regulation of cell diameter|
|regulation of inositol-polyphosphate 5-phosphatase activity|
|protein secretion by platelet|
|positive regulation of platelet activation|
|positive regulation of integrin activation|
|thrombin-activated receptor signaling pathway|
|regulation of integrin activation|
|negative regulation of alcohol biosynthetic process|
|positive regulation of actin filament depolymerization|
|protein kinase C signaling|
|regulation of inositol phosphate biosynthetic process|
|positive regulation of protein depolymerization|
|ruffle organization|
|positive regulation of blood coagulation|
|positive regulation of hemostasis|
|positive regulation of coagulation|
|negative regulation of calcium-mediated signaling|
|phosphatidylinositol-3,4-bisphosphate binding|
|regulation of platelet activation|
|positive regulation of phosphatase activity|
|positive regulation of protein complex disassembly|
|vesicle docking involved in exocytosis|
|cortical actin cytoskeleton organization|
|negative regulation of cellular carbohydrate metabolic process|
|platelet aggregation|
|cortical cytoskeleton organization|
|negative regulation of G protein-coupled receptor signaling pathway|
|negative regulation of carbohydrate metabolic process|
|regulation of actin filament depolymerization|
|protein kinase C binding|
|positive regulation of wound healing|
|positive regulation of dephosphorylation|
|homotypic cell-cell adhesion|
|positive regulation of actin filament bundle assembly|
|vesicle docking|
|positive regulation of response to wounding|
|actin cytoskeleton reorganization|
|exocytic process|
|regulation of alcohol biosynthetic process|
|regulation of blood coagulation|
|regulation of hemostasis|
|regulation of coagulation|
|regulation of protein depolymerization|
|hematopoietic progenitor cell differentiation|
|negative regulation of small molecule metabolic process|
|regulation of actin filament bundle assembly|
|integrin-mediated signaling pathway|
|regulation of carbohydrate biosynthetic process|
|ruffle membrane|
|regulation of calcium-mediated signaling|
|regulation of protein complex disassembly|
|platelet degranulation|
|platelet activation|
|regulation of wound healing|
|regulation of cellular carbohydrate metabolic process|
|regulation of G protein-coupled receptor signaling pathway|
|protein secretion|
|establishment of protein localization to extracellular region|
|protein localization to extracellular region|
|regulation of response to wounding|
|phosphatidylinositol metabolic process|
|organelle localization by membrane tethering|
|peptide secretion|
|regulation of phosphatase activity|
|membrane docking|
|regulation of cell size|
|regulation of actin polymerization or depolymerization|
|regulation of actin filament length|
|positive regulation of supramolecular fiber organization|
|regulation of carbohydrate metabolic process|
|regulation of dephosphorylation|
|positive regulation of cytoskeleton organization|
|positive regulation of protein complex assembly|
|regulation of actin filament organization|
|blood coagulation|
|coagulation|
|hemostasis|
|glycerophospholipid metabolic process|
|regulation of actin cytoskeleton organization|
|regulation of supramolecular fiber organization|
|phospholipid metabolic process|
|regulation of cellular component size|
|glycerolipid metabolic process|
|regulation of actin filament-based process|
|positive regulation of cell activation|
|regulation of small molecule metabolic process|
|regulation of protein complex assembly|
|wound healing|
|actin cytoskeleton organization|
|regulation of body fluid levels|
|cell-cell adhesion|
|negative regulation of intracellular signal transduction|
|regulation of anatomical structure size|
|positive regulation of cellular component biogenesis|
|regulation of cytoskeleton organization|
|hemopoiesis|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|actin filament-based process|
|response to wounding|
|organelle localization|
|hematopoietic or lymphoid organ development|
|positive regulation of organelle organization|
|regulation of cell activation|
|immune system development|
|regulated exocytosis|
|positive regulation of hydrolase activity|
|exocytosis|
|protein homodimerization activity|
|organophosphate metabolic process|
|cell adhesion|
|biological adhesion|
|cellular lipid metabolic process|
|regulation of cellular component biogenesis|
|secretion by cell|
|export from cell|
|cell activation|
|regulation of response to external stimulus|
|cytoskeleton organization|
|plasma membrane bounded cell projection organization|
|secretion|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|cell projection organization|
|positive regulation of cellular component organization|
|lipid metabolic process|
|negative regulation of signal transduction|
|regulation of hydrolase activity|
|regulation of organelle organization|
|G protein-coupled receptor signaling pathway|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of catalytic activity|
|regulation of response to stress|
|protein transport|
|negative regulation of cellular biosynthetic process|
|peptide transport|
|negative regulation of biosynthetic process|
|amide transport|
|establishment of protein localization|
|negative regulation of response to stimulus|
|intracellular signal transduction|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of intracellular signal transduction|
|nitrogen compound transport|
|extracellular region|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9485
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.17 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PLEK Expression in NALM6 Cells: -1.17'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>