PLEKHA1 [The Human Chemical-Genetic Interaction Map Project]

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======= PLEKHA1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PLEKHA1
  * **<color #00a2e8>Official Name</color>**: pleckstrin homology domain containing A1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=59338|59338]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9HB21|Q9HB21]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PLEKHA1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PLEKHA1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607772|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a pleckstrin homology domain-containing adapter protein. The encoded protein is localized to the plasma membrane where it specifically binds phosphatidylinositol 3,4-bisphosphate. This protein may be involved in the formation of signaling complexes in the plasma membrane. Polymorphisms in this gene are associated with age-related macular degeneration. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 5.[provided by RefSeq, Sep 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Binds specifically to phosphatidylinositol 3,4- diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane. {ECO:0000269|PubMed:11001876, ECO:0000269|PubMed:11513726, ECO:0000269|PubMed:14516276}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PH|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|luteinization|
|Leydig cell differentiation|
|ruffle organization|
|androgen metabolic process|
|phosphatidylinositol-3,4-bisphosphate binding|
|face morphogenesis|
|estrogen metabolic process|
|phosphatidylinositol 3-kinase signaling|
|platelet-derived growth factor receptor signaling pathway|
|head morphogenesis|
|ovulation cycle process|
|body morphogenesis|
|negative regulation of protein kinase B signaling|
|face development|
|ovulation cycle|
|cellular response to hydrogen peroxide|
|phosphatidylinositol-mediated signaling|
|inositol lipid-mediated signaling|
|multicellular organism growth|
|female gonad development|
|PDZ domain binding|
|post-embryonic development|
|roof of mouth development|
|development of primary female sexual characteristics|
|ruffle membrane|
|female sex differentiation|
|phosphatidylinositol biosynthetic process|
|cellular response to antibiotic|
|response to hydrogen peroxide|
|cellular hormone metabolic process|
|B cell receptor signaling pathway|
|cellular response to reactive oxygen species|
|male gonad development|
|development of primary male sexual characteristics|
|male sex differentiation|
|phosphatidylinositol metabolic process|
|response to reactive oxygen species|
|hormone metabolic process|
|glycerophospholipid biosynthetic process|
|gonad development|
|cellular response to toxic substance|
|development of primary sexual characteristics|
|regulation of protein kinase B signaling|
|glycerolipid biosynthetic process|
|skeletal system morphogenesis|
|cellular response to oxidative stress|
|phospholipid biosynthetic process|
|steroid metabolic process|
|sex differentiation|
|rhythmic process|
|antigen receptor-mediated signaling pathway|
|response to antibiotic|
|glycerophospholipid metabolic process|
|phospholipid metabolic process|
|glycerolipid metabolic process|
|response to oxidative stress|
|developmental growth|
|growth|
|cellular response to drug|
|reproductive structure development|
|reproductive system development|
|immune response-activating cell surface receptor signaling pathway|
|immune response-regulating cell surface receptor signaling pathway|
|skeletal system development|
|negative regulation of intracellular signal transduction|
|response to toxic substance|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|regulation of hormone levels|
|response to inorganic substance|
|organophosphate biosynthetic process|
|spermatogenesis|
|immune response-activating signal transduction|
|male gamete generation|
|lipid biosynthetic process|
|immune response-regulating signaling pathway|
|activation of immune response|
|developmental process involved in reproduction|
|gamete generation|
|enzyme linked receptor protein signaling pathway|
|head development|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|positive regulation of immune response|
|organophosphate metabolic process|
|animal organ morphogenesis|
|cellular lipid metabolic process|
|multi-organism reproductive process|
|response to drug|
|cellular response to oxygen-containing compound|
|plasma membrane bounded cell projection organization|
|positive regulation of immune system process|
|regulation of immune response|
|cell projection organization|
|lipid metabolic process|
|negative regulation of signal transduction|
|negative regulation of cell communication|
|negative regulation of signaling|
|reproductive process|
|reproduction|
|response to oxygen-containing compound|
|establishment of protein localization|
|negative regulation of response to stimulus|
|regulation of immune system process|
|intracellular signal transduction|
|cellular response to stress|
|regulation of intracellular signal transduction|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp280|Daidzin 10μM R06 exp280]]|1.73|
|[[:results:exp159|Docetaxel 0.001 to 0.002μM on day4 R04 exp159]]|1.74|
|[[:results:exp13|Chloramphenicol 20μM R00 exp13]]|1.8|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18149
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.52 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PLEKHA1 Expression in NALM6 Cells: 5.52'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>