PLEKHG5 [The Human Chemical-Genetic Interaction Map Project]

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======= PLEKHG5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PLEKHG5
  * **<color #00a2e8>Official Name</color>**: pleckstrin homology and RhoGEF domain containing G5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=57449|57449]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O94827|O94827]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PLEKHG5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PLEKHG5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611101|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a protein that activates the nuclear factor kappa B (NFKB1) signaling pathway. Mutations in this gene are associated with autosomal recessive distal spinal muscular atrophy. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RhoGEF|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of protein catabolic process at presynapse, modulating synaptic transmission|
|endothelial cell chemotaxis|
|presynaptic modulation of chemical synaptic transmission|
|endocytic vesicle|
|endothelial cell migration|
|Rho guanyl-nucleotide exchange factor activity|
|epithelial cell migration|
|epithelium migration|
|tissue migration|
|presynapse|
|regulation of Rho protein signal transduction|
|ameboidal-type cell migration|
|cell-cell junction|
|lamellipodium|
|positive regulation of I-kappaB kinase/NF-kappaB signaling|
|cell chemotaxis|
|regulation of I-kappaB kinase/NF-kappaB signaling|
|regulation of Ras protein signal transduction|
|regulation of small GTPase mediated signal transduction|
|regulation of protein catabolic process|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|chemotaxis|
|taxis|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|positive regulation of cell death|
|perinuclear region of cytoplasm|
|cell migration|
|regulation of catabolic process|
|positive regulation of intracellular signal transduction|
|cell motility|
|localization of cell|
|locomotion|
|G protein-coupled receptor signaling pathway|
|regulation of apoptotic process|
|movement of cell or subcellular component|
|regulation of programmed cell death|
|positive regulation of signal transduction|
|regulation of cell death|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2731
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.33 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PLEKHG5 Expression in NALM6 Cells: 0.33'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>