PLK1 [The Human Chemical-Genetic Interaction Map Project]

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======= PLK1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PLK1
  * **<color #00a2e8>Official Name</color>**: polo like kinase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5347|5347]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P53350|P53350]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PLK1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PLK1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602098|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Serine/threonine-protein kinase that performs several important functions throughout M phase of the cell cycle, including the regulation of centrosome maturation and spindle assembly, the removal of cohesins from chromosome arms, the inactivation of anaphase-promoting complex/cyclosome (APC/C) inhibitors, and the regulation of mitotic exit and cytokinesis. Polo-like kinase proteins acts by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates BORA, BUB1B/BUBR1, CCNB1, CDC25C, CEP55, ECT2, ERCC6L, FBXO5/EMI1, FOXM1, KIF20A/MKLP2, CENPU, NEDD1, NINL, NPM1, NUDC, PKMYT1/MYT1, KIZ, PPP1R12A/MYPT1, PRC1, RACGAP1/CYK4, SGO1, STAG2/SA2, TEX14, TOPORS, p73/TP73, TPT1, WEE1 and HNRNPU. Plays a key role in centrosome functions and the assembly of bipolar spindles by phosphorylating KIZ, NEDD1 and NINL. NEDD1 phosphorylation promotes subsequent targeting of the gamma-tubulin ring complex (gTuRC) to the centrosome, an important step for spindle formation. Phosphorylation of NINL component of the centrosome leads to NINL dissociation from other centrosomal proteins. Involved in mitosis exit and cytokinesis by phosphorylating CEP55, ECT2, KIF20A/MKLP2, CENPU, PRC1 and RACGAP1. Recruited at the central spindle by phosphorylating and docking PRC1 and KIF20A/MKLP2; creates its own docking sites on PRC1 and KIF20A/MKLP2 by mediating phosphorylation of sites subsequently recognized by the POLO box domains. Phosphorylates RACGAP1, thereby creating a docking site for the Rho GTP exchange factor ECT2 that is essential for the cleavage furrow formation. Promotes the central spindle recruitment of ECT2. Plays a central role in G2/M transition of mitotic cell cycle by phosphorylating CCNB1, CDC25C, FOXM1, CENPU, PKMYT1/MYT1, PPP1R12A/MYPT1 and WEE1. Part of a regulatory circuit that promotes the activation of CDK1 by phosphorylating the positive regulator CDC25C and inhibiting the negative regulators WEE1 and PKMYT1/MYT1. Also acts by mediating phosphorylation of cyclin-B1 (CCNB1) on centrosomes in prophase. Phosphorylates FOXM1, a key mitotic transcription regulator, leading to enhance FOXM1 transcriptional activity. Involved in kinetochore functions and sister chromatid cohesion by phosphorylating BUB1B/BUBR1, FBXO5/EMI1 and STAG2/SA2. PLK1 is high on non-attached kinetochores suggesting a role of PLK1 in kinetochore attachment or in spindle assembly checkpoint (SAC) regulation. Required for kinetochore localization of BUB1B. Regulates the dissociation of cohesin from chromosomes by phosphorylating cohesin subunits such as STAG2/SA2. Phosphorylates SGO1: required for spindle pole localization of isoform 3 of SGO1 and plays a role in regulating its centriole cohesion function. Mediates phosphorylation of FBXO5/EMI1, a negative regulator of the APC/C complex during prophase, leading to FBXO5/EMI1 ubiquitination and degradation by the proteasome. Acts as a negative regulator of p53 family members: phosphorylates TOPORS, leading to inhibit the sumoylation of p53/TP53 and simultaneously enhance the ubiquitination and subsequent degradation of p53/TP53. Phosphorylates the transactivation domain of the transcription factor p73/TP73, leading to inhibit p73/TP73-mediated transcriptional activation and pro-apoptotic functions. Phosphorylates BORA, and thereby promotes the degradation of BORA. Contributes to the regulation of AURKA function. Also required for recovery after DNA damage checkpoint and entry into mitosis. Phosphorylates MISP, leading to stabilization of cortical and astral microtubule attachments required for proper spindle positioning (PubMed:8991084, PubMed:11202906, PubMed:12207013, PubMed:12447691, PubMed:12524548, PubMed:12738781, PubMed:12852856, PubMed:12939256, PubMed:14532005, PubMed:14734534, PubMed:15070733, PubMed:15148369, PubMed:15469984, PubMed:16198290, PubMed:16247472, PubMed:16980960, PubMed:17081991, PubMed:17351640, PubMed:17376779, PubMed:17617734, PubMed:18174154, PubMed:18331714, PubMed:18418051, PubMed:18477460, PubMed:18521620, PubMed:18615013, PubMed:19160488, PubMed:19351716, PubMed:19468300, PubMed:19468302, PubMed:19473992, PubMed:19509060, PubMed:19597481, PubMed:23455478, PubMed:23509069). Together with MEIKIN, acts as a regulator of kinetochore function during meiosis I: required both for mono-orientation of kinetochores on sister chromosomes and protection of centromeric cohesin from separase-mediated cleavage (By similarity). Phosphorylates CEP68 and is required for its degradation (PubMed:25503564). Regulates nuclear envelope breakdown during prophase by phosphorylating DCTN1 resulting in its localization in the nuclear envelope (PubMed:20679239). Phosphorylates the heat shock transcription factor HSF1, promoting HSF1 nuclear translocation upon heat shock (PubMed:15661742). Phosphorylates HSF1 also in the early mitotic period; this phosphorylation regulates HSF1 localization to the spindle pole, the recruitment of the SCF(BTRC) ubiquitin ligase complex induicing HSF1 degradation, and hence mitotic progression (PubMed:18794143). Regulates mitotic progression by phosphorylating RIOK2 (PubMed:21880710). {ECO:0000250|UniProtKB:Q5F2C3, ECO:0000269|PubMed:11202906, ECO:0000269|PubMed:12207013, ECO:0000269|PubMed:12447691, ECO:0000269|PubMed:12524548, ECO:0000269|PubMed:12738781, ECO:0000269|PubMed:12852856, ECO:0000269|PubMed:12939256, ECO:0000269|PubMed:14532005, ECO:0000269|PubMed:14734534, ECO:0000269|PubMed:15070733, ECO:0000269|PubMed:15148369, ECO:0000269|PubMed:15469984, ECO:0000269|PubMed:15661742, ECO:0000269|PubMed:16198290, ECO:0000269|PubMed:16247472, ECO:0000269|PubMed:16980960, ECO:0000269|PubMed:17081991, ECO:0000269|PubMed:17351640, ECO:0000269|PubMed:17376779, ECO:0000269|PubMed:17617734, ECO:0000269|PubMed:18174154, ECO:0000269|PubMed:18331714, ECO:0000269|PubMed:18418051, ECO:0000269|PubMed:18477460, ECO:0000269|PubMed:18521620, ECO:0000269|PubMed:18615013, ECO:0000269|PubMed:18794143, ECO:0000269|PubMed:19160488, ECO:0000269|PubMed:19351716, ECO:0000269|PubMed:19468300, ECO:0000269|PubMed:19468302, ECO:0000269|PubMed:19473992, ECO:0000269|PubMed:19509060, ECO:0000269|PubMed:19597481, ECO:0000269|PubMed:20679239, ECO:0000269|PubMed:21880710, ECO:0000269|PubMed:23455478, ECO:0000269|PubMed:23509069, ECO:0000269|PubMed:25503564, ECO:0000269|PubMed:25986610, ECO:0000269|PubMed:8991084}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pkinase|
|Pkinase Tyr|
|POLO box|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|synaptonemal complex disassembly|
|condensed nuclear chromosome outer kinetochore|
|female meiosis chromosome segregation|
|regulation of protein localization to cell cortex|
|anaphase-promoting complex binding|
|protein localization to nuclear envelope|
|mitotic nuclear envelope disassembly|
|signal transduction involved in G2 DNA damage checkpoint|
|positive regulation of ubiquitin protein ligase activity|
|membrane disassembly|
|nuclear envelope disassembly|
|spindle checkpoint|
|spindle assembly checkpoint|
|regulation of mitotic spindle assembly|
|mitotic spindle checkpoint|
|mitotic spindle assembly checkpoint|
|regulation of ubiquitin protein ligase activity|
|synaptonemal complex organization|
|protein localization to chromatin|
|negative regulation of mitotic metaphase/anaphase transition|
|negative regulation of metaphase/anaphase transition of cell cycle|
|synaptonemal complex|
|spindle midzone|
|negative regulation of mitotic sister chromatid separation|
|negative regulation of chromosome separation|
|regulation of spindle assembly|
|establishment of mitotic spindle orientation|
|G2 DNA damage checkpoint|
|negative regulation of cyclin-dependent protein serine/threonine kinase activity|
|positive regulation of peptidyl-threonine phosphorylation|
|negative regulation of cyclin-dependent protein kinase activity|
|negative regulation of mitotic sister chromatid segregation|
|centriolar satellite|
|female meiotic nuclear division|
|negative regulation of sister chromatid segregation|
|positive regulation of ubiquitin-protein transferase activity|
|negative regulation of chromosome segregation|
|establishment of mitotic spindle localization|
|establishment of spindle orientation|
|spindle microtubule|
|regulation of mitotic spindle organization|
|negative regulation of mitotic nuclear division|
|establishment of spindle localization|
|regulation of spindle organization|
|regulation of peptidyl-threonine phosphorylation|
|protein destabilization|
|negative regulation of nuclear division|
|spindle localization|
|sister chromatid cohesion|
|regulation of ubiquitin-protein transferase activity|
|regulation of mitotic metaphase/anaphase transition|
|nuclear envelope organization|
|regulation of metaphase/anaphase transition of cell cycle|
|regulation of mitotic sister chromatid separation|
|homologous chromosome segregation|
|regulation of chromosome separation|
|protein localization to chromosome|
|regulation of mitotic sister chromatid segregation|
|mitotic cytokinesis|
|signal transduction involved in DNA integrity checkpoint|
|signal transduction involved in DNA damage checkpoint|
|signal transduction involved in cell cycle checkpoint|
|positive regulation of protein localization to nucleus|
|kinase activity|
|regulation of sister chromatid segregation|
|anaphase-promoting complex-dependent catabolic process|
|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|
|centrosome cycle|
|kinetochore|
|meiotic chromosome segregation|
|regulation of cytokinesis|
|microtubule bundle formation|
|microtubule organizing center organization|
|ciliary basal body-plasma membrane docking|
|cytoskeleton-dependent cytokinesis|
|positive regulation of ubiquitin-dependent protein catabolic process|
|regulation of cyclin-dependent protein serine/threonine kinase activity|
|cytokinesis|
|negative regulation of cell cycle G2/M phase transition|
|regulation of chromosome segregation|
|regulation of cyclin-dependent protein kinase activity|
|microtubule cytoskeleton organization involved in mitosis|
|positive regulation of proteasomal protein catabolic process|
|signal transduction in response to DNA damage|
|mitotic sister chromatid segregation|
|meiosis I|
|meiosis I cell cycle process|
|chromatin|
|regulation of protein localization to cell periphery|
|positive regulation of protein ubiquitination|
|regulation of protein localization to nucleus|
|establishment of cell polarity|
|spindle|
|positive regulation of proteolysis involved in cellular protein catabolic process|
|spindle pole|
|regulation of proteasomal ubiquitin-dependent protein catabolic process|
|female gamete generation|
|G2/M transition of mitotic cell cycle|
|DNA damage checkpoint|
|nucleus organization|
|negative regulation of protein serine/threonine kinase activity|
|cell cycle G2/M phase transition|
|positive regulation of protein modification by small protein conjugation or removal|
|negative regulation of chromosome organization|
|positive regulation of cellular protein catabolic process|
|centriole|
|sister chromatid segregation|
|DNA integrity checkpoint|
|mitotic nuclear division|
|meiotic nuclear division|
|microtubule cytoskeleton|
|mitotic cell cycle checkpoint|
|regulation of ubiquitin-dependent protein catabolic process|
|midbody|
|protein localization to nucleus|
|meiotic cell cycle process|
|regulation of mitotic nuclear division|
|regulation of cell division|
|organelle localization by membrane tethering|
|peptidyl-serine phosphorylation|
|membrane docking|
|regulation of proteasomal protein catabolic process|
|regulation of microtubule cytoskeleton organization|
|regulation of nuclear division|
|cell cycle checkpoint|
|regulation of G2/M transition of mitotic cell cycle|
|establishment or maintenance of cell polarity|
|peptidyl-serine modification|
|regulation of protein ubiquitination|
|regulation of cell cycle G2/M phase transition|
|negative regulation of mitotic cell cycle phase transition|
|magnesium ion binding|
|regulation of proteolysis involved in cellular protein catabolic process|
|positive regulation of protein catabolic process|
|nuclear chromosome segregation|
|regulation of protein binding|
|regulation of organelle assembly|
|regulation of microtubule-based process|
|meiotic cell cycle|
|negative regulation of protein kinase activity|
|regulation of protein modification by small protein conjugation or removal|
|negative regulation of cell cycle phase transition|
|microtubule binding|
|protein kinase activity|
|negative regulation of kinase activity|
|regulation of cellular protein catabolic process|
|mitotic cell cycle phase transition|
|chromosome segregation|
|negative regulation of transferase activity|
|cell cycle phase transition|
|nuclear division|
|regulation of protein stability|
|negative regulation of mitotic cell cycle|
|organelle fission|
|proteasome-mediated ubiquitin-dependent protein catabolic process|
|positive regulation of cellular protein localization|
|negative regulation of cell cycle process|
|cilium assembly|
|regulation of chromosome organization|
|proteasomal protein catabolic process|
|cellular process involved in reproduction in multicellular organism|
|positive regulation of proteolysis|
|establishment of organelle localization|
|protein serine/threonine kinase activity|
|positive regulation of cellular catabolic process|
|cilium organization|
|negative regulation of organelle organization|
|regulation of binding|
|regulation of protein catabolic process|
|cellular component disassembly|
|negative regulation of protein phosphorylation|
|regulation of mitotic cell cycle phase transition|
|endomembrane system organization|
|positive regulation of catabolic process|
|negative regulation of phosphorylation|
|plasma membrane bounded cell projection assembly|
|regulation of cell cycle phase transition|
|cell projection assembly|
|protein kinase binding|
|microtubule cytoskeleton organization|
|centrosome|
|cell division|
|regulation of protein serine/threonine kinase activity|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|regulation of cellular protein localization|
|regulation of cytoskeleton organization|
|modification-dependent macromolecule catabolic process|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|negative regulation of cell cycle|
|organelle localization|
|proteolysis involved in cellular protein catabolic process|
|negative regulation of protein modification process|
|mitotic cell cycle process|
|cellular protein catabolic process|
|regulation of mitotic cell cycle|
|positive regulation of transferase activity|
|microtubule-based process|
|protein catabolic process|
|mitotic cell cycle|
|protein ubiquitination|
|gamete generation|
|negative regulation of cellular component organization|
|regulation of proteolysis|
|protein localization to organelle|
|regulation of cell cycle process|
|organelle assembly|
|protein modification by small protein conjugation|
|cellular response to DNA damage stimulus|
|negative regulation of catalytic activity|
|regulation of protein kinase activity|
|multicellular organismal reproductive process|
|sexual reproduction|
|regulation of cellular catabolic process|
|multicellular organism reproduction|
|membrane organization|
|negative regulation of transcription by RNA polymerase II|
|regulation of kinase activity|
|peptidyl-amino acid modification|
|negative regulation of apoptotic process|
|cellular macromolecule catabolic process|
|negative regulation of programmed cell death|
|regulation of cellular localization|
|regulation of cellular component biogenesis|
|protein phosphorylation|
|regulation of transferase activity|
|protein modification by small protein conjugation or removal|
|negative regulation of cell death|
|multi-organism reproductive process|
|regulation of catabolic process|
|cell cycle process|
|positive regulation of protein phosphorylation|
|regulation of protein localization|
|negative regulation of cellular protein metabolic process|
|macromolecule catabolic process|
|positive regulation of phosphorylation|
|organonitrogen compound catabolic process|
|chromosome organization|
|identical protein binding|
|negative regulation of protein metabolic process|
|cytoskeleton organization|
|plasma membrane bounded cell projection organization|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|negative regulation of molecular function|
|cell projection organization|
|regulation of cell cycle|
|negative regulation of transcription, DNA-templated|
|positive regulation of protein modification process|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|proteolysis|
|phosphorylation|
|regulation of organelle organization|
|negative regulation of RNA metabolic process|
|cell cycle|
|negative regulation of cellular macromolecule biosynthetic process|
|reproductive process|
|reproduction|
|positive regulation of catalytic activity|
|negative regulation of nucleobase-containing compound metabolic process|
|regulation of protein phosphorylation|
|negative regulation of macromolecule biosynthetic process|
|ATP binding|
|negative regulation of cellular biosynthetic process|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|regulation of programmed cell death|
|cellular protein localization|
|regulation of phosphorylation|
|cellular macromolecule localization|
|positive regulation of cellular protein metabolic process|
|establishment of protein localization|
|regulation of cell death|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|organic substance catabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|cellular catabolic process|
|establishment of localization in cell|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp492|iCRT14 30μM R08 exp492]]|-2.6|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|-2.39|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|-2.07|
|[[:results:exp521|Salinomycin 3.5μM R08 exp521]]|-2.07|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|-2.02|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|-1.98|
|[[:results:exp536|Vitamin-D3 40μM R08 exp536]]|-1.97|
|[[:results:exp26|Oligomycin-A 20μM R00 exp26]]|-1.96|
|[[:results:exp183|IU1-C 25μM R04 exp183]]|-1.84|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|-1.75|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|-1.74|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|-1.71|
|[[:results:exp1|5-Fluorouracil 2μM R00 exp1]]|1.81|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|1.81|
|[[:results:exp58|UM131593 0.1μM R01 exp58]]|1.82|
|[[:results:exp61|YM155 0.0002μM R01 exp61]]|1.9|
|[[:results:exp46|HMS-I1 1μM R01 exp46]]|2.02|
|[[:results:exp248|UM0131023 0.05μM R05 exp248]]|2.07|
|[[:results:exp222|Betulinic acid 10 to 15μM on day4 R05 exp222]]|2.09|
|[[:results:exp278|CVT-10216 0.1μM R06 exp278]]|2.11|
|[[:results:exp291|LLY-284 2.6μM R06 exp291]]|2.22|
|[[:results:exp286|HMS-I2 1μM R06 exp286]]|2.3|
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|2.62|
|[[:results:exp54|Taxol 0.002μM R01 exp54]]|3.05|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:m:mt1e|MT1E]]|0.52|
|[[:human genes:p:psmd3|PSMD3]]|0.501|
|[[:human genes:p:polr2j3|POLR2J3]]|0.499|
|[[:human genes:n:nuf2|NUF2]]|0.496|
|[[:human genes:t:ticrr|TICRR]]|0.495|
|[[:human genes:r:rad21|RAD21]]|0.493|
|[[:human genes:t:tceb3c|TCEB3C]]|0.485|
|[[:human genes:c:c14orf93|C14orf93]]|0.481|
|[[:human genes:v:vasn|VASN]]|0.472|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.472|
|[[:human genes:p:psma6|PSMA6]]|0.471|
|[[:human genes:d:dtl|DTL]]|0.469|
|[[:human genes:k:krt78|KRT78]]|0.468|
|[[:human genes:p:psmb2|PSMB2]]|0.461|
|[[:human genes:s:supt5h|SUPT5H]]|0.456|
|[[:human genes:c:cbwd3|CBWD3]]|0.455|
|[[:human genes:a:aqr|AQR]]|0.452|
|[[:human genes:n:npipb8|NPIPB8]]|0.446|
|[[:human genes:c:clasp1|CLASP1]]|0.445|
|[[:human genes:r:rbm39|RBM39]]|0.444|
|[[:human genes:n:narfl|NARFL]]|0.443|
|[[:human genes:a:aaas|AAAS]]|0.443|
|[[:human genes:p:psmc1|PSMC1]]|0.443|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.441|
|[[:human genes:r:rpl35|RPL35]]|0.441|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.44|
|[[:human genes:s:syt9|SYT9]]|0.44|
|[[:human genes:g:golga6l3|GOLGA6L3]]|0.433|
|[[:human genes:c:cbwd6|CBWD6]]|0.433|
|[[:human genes:s:slc4a1|SLC4A1]]|0.432|
|[[:human genes:n:nup160|NUP160]]|0.432|
|[[:human genes:s:ssh2|SSH2]]|0.432|
|[[:human genes:h:hinfp|HINFP]]|0.431|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.431|
|[[:human genes:s:supt6h|SUPT6H]]|0.429|
|[[:human genes:o:orc6|ORC6]]|0.428|
|[[:human genes:d:dhfr|DHFR]]|0.427|
|[[:human genes:r:rps7|RPS7]]|0.427|
|[[:human genes:a:ahctf1|AHCTF1]]|0.426|
|[[:human genes:i:iscu|ISCU]]|0.425|
|[[:human genes:d:dock6|DOCK6]]|0.425|
|[[:human genes:p:psmb1|PSMB1]]|0.424|
|[[:human genes:n:nupl1|NUPL1]]|0.424|
|[[:human genes:c:cln6|CLN6]]|0.424|
|[[:human genes:h:haus4|HAUS4]]|0.422|
|[[:human genes:h:hist1h2be|HIST1H2BE]]|0.422|
|[[:human genes:u:uqcrh|UQCRH]]|0.422|
|[[:human genes:l:lrr1|LRR1]]|0.422|
|[[:human genes:u:ubl5|UBL5]]|0.421|
|[[:human genes:g:gprin2|GPRIN2]]|0.419|
|[[:human genes:e:exosc9|EXOSC9]]|0.419|
|[[:human genes:c:cdc73|CDC73]]|0.418|
|[[:human genes:p:polr2a|POLR2A]]|0.418|
|[[:human genes:s:snrpa1|SNRPA1]]|0.417|
|[[:human genes:p:pan3|PAN3]]|0.416|
|[[:human genes:m:med15|MED15]]|0.416|
|[[:human genes:m:mat2a|MAT2A]]|0.416|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.416|
|[[:human genes:c:col2a1|COL2A1]]|0.415|
|[[:human genes:r:rps2|RPS2]]|0.415|
|[[:human genes:d:ddtl|DDTL]]|0.414|
|[[:human genes:c:cactin|CACTIN]]|0.414|
|[[:human genes:k:krt2|KRT2]]|0.413|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.413|
|[[:human genes:s:sh3bp1|SH3BP1]]|0.413|
|[[:human genes:r:rad51|RAD51]]|0.412|
|[[:human genes:g:golga6l6|GOLGA6L6]]|0.411|
|[[:human genes:x:xab2|XAB2]]|0.411|
|[[:human genes:c:cdc6|CDC6]]|0.411|
|[[:human genes:t:ttyh1|TTYH1]]|0.411|
|[[:human genes:c:cbwd5|CBWD5]]|0.411|
|[[:human genes:p:psmd6|PSMD6]]|0.411|
|[[:human genes:p:psma7|PSMA7]]|0.41|
|[[:human genes:s:scaf1|SCAF1]]|0.409|
|[[:human genes:k:kpnb1|KPNB1]]|0.408|
|[[:human genes:d:dnm2|DNM2]]|0.408|
|[[:human genes:r:rpsa|RPSA]]|0.408|
|[[:human genes:l:lrrc56|LRRC56]]|0.407|
|[[:human genes:f:fam231a|FAM231A]]|0.406|
|[[:human genes:c:cdc45|CDC45]]|0.405|
|[[:human genes:i:igfn1|IGFN1]]|0.405|
|[[:human genes:f:fam231c|FAM231C]]|0.405|
|[[:human genes:n:ndc80|NDC80]]|0.405|
|[[:human genes:a:atp6v0c|ATP6V0C]]|0.404|
|[[:human genes:s:sec13|SEC13]]|0.404|
|[[:human genes:g:golga6l1|GOLGA6L1]]|0.404|
|[[:human genes:c:chmp2a|CHMP2A]]|0.404|
|[[:human genes:s:sap30bp|SAP30BP]]|0.403|
|[[:human genes:c:chd4|CHD4]]|0.403|
|[[:human genes:f:fam160a1|FAM160A1]]|0.401|
|[[:human genes:g:golga6l4|GOLGA6L4]]|0.401|
|[[:human genes:o:or10g3|OR10G3]]|0.4|
|[[:human genes:b:bora|BORA]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 723/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|28/28|
|bone|25/25|
|breast|33/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|15/15|
|kidney|20/21|
|liver|20/20|
|lung|75/75|
|lymphocyte|14/14|
|ovary|26/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|7/7|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|29/29|
|uterus|4/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 435
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.1 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PLK1 Expression in NALM6 Cells: 7.1'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>