PLK2 [The Human Chemical-Genetic Interaction Map Project]

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======= PLK2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PLK2
  * **<color #00a2e8>Official Name</color>**: polo like kinase 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10769|10769]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NYY3|Q9NYY3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PLK2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PLK2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607023|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Tumor suppressor serine/threonine-protein kinase involved in synaptic plasticity, centriole duplication and G1/S phase transition. Polo-like kinases act by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates CENPJ, NPM1, RAPGEF2, RASGRF1, SNCA, SIPA1L1 and SYNGAP1. Plays a key role in synaptic plasticity and memory by regulating the Ras and Rap protein signaling: required for overactivity-dependent spine remodeling by phosphorylating the Ras activator RASGRF1 and the Rap inhibitor SIPA1L1 leading to their degradation by the proteasome. Conversely, phosphorylates the Rap activator RAPGEF2 and the Ras inhibitor SYNGAP1, promoting their activity. Also regulates synaptic plasticity independently of kinase activity, via its interaction with NSF that disrupts the interaction between NSF and the GRIA2 subunit of AMPARs, leading to a rapid rundown of AMPAR-mediated current that occludes long term depression. Required for procentriole formation and centriole duplication by phosphorylating CENPJ and NPM1, respectively. Its induction by p53/TP53 suggests that it may participate in the mitotic checkpoint following stress. {ECO:0000269|PubMed:15242618, ECO:0000269|PubMed:19001868, ECO:0000269|PubMed:20352051, ECO:0000269|PubMed:20531387}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|POLO box|
|Pkinase|
|Pkinase Tyr|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of apoptotic process in bone marrow cell|
|regulation of apoptotic process in bone marrow cell|
|ATP-dependent protein binding|
|Rap protein signal transduction|
|negative regulation of dendritic spine development|
|long-term synaptic depression|
|negative regulation of cellular senescence|
|positive regulation of cell migration involved in sprouting angiogenesis|
|regulation of centriole replication|
|negative regulation of cell aging|
|negative regulation of dendrite development|
|regulation of cell migration involved in sprouting angiogenesis|
|positive regulation of sprouting angiogenesis|
|regulation of cellular senescence|
|regulation of centrosome duplication|
|long-term synaptic potentiation|
|regulation of cell aging|
|positive regulation of blood vessel endothelial cell migration|
|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|
|signal transduction involved in mitotic DNA damage checkpoint|
|signal transduction involved in mitotic cell cycle checkpoint|
|signal transduction involved in mitotic G1 DNA damage checkpoint|
|intracellular signal transduction involved in G1 DNA damage checkpoint|
|signal transduction involved in mitotic DNA integrity checkpoint|
|regulation of centrosome cycle|
|negative regulation of synaptic transmission|
|mitotic G1 DNA damage checkpoint|
|mitotic G1/S transition checkpoint|
|G1 DNA damage checkpoint|
|regulation of sprouting angiogenesis|
|signal transduction involved in DNA integrity checkpoint|
|signal transduction involved in DNA damage checkpoint|
|signal transduction involved in cell cycle checkpoint|
|regulation of dendritic spine development|
|mitotic spindle organization|
|DNA damage response, signal transduction by p53 class mediator|
|positive regulation of cell cycle arrest|
|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|
|regulation of cytokinesis|
|regulation of blood vessel endothelial cell migration|
|positive regulation of protein binding|
|mitotic DNA damage checkpoint|
|positive regulation of ubiquitin-dependent protein catabolic process|
|positive regulation of endothelial cell migration|
|negative regulation of angiogenesis|
|negative regulation of G1/S transition of mitotic cell cycle|
|mitotic DNA integrity checkpoint|
|microtubule cytoskeleton organization involved in mitosis|
|positive regulation of proteasomal protein catabolic process|
|signal transduction in response to DNA damage|
|negative regulation of blood vessel morphogenesis|
|negative regulation of cell cycle G1/S phase transition|
|regulation of cell cycle arrest|
|chromatin|
|negative regulation of vasculature development|
|memory|
|G1/S transition of mitotic cell cycle|
|signal transduction by p53 class mediator|
|cell cycle G1/S phase transition|
|positive regulation of autophagy|
|positive regulation of proteolysis involved in cellular protein catabolic process|
|spindle pole|
|regulation of proteasomal ubiquitin-dependent protein catabolic process|
|DNA damage checkpoint|
|positive regulation of epithelial cell migration|
|positive regulation of cellular protein catabolic process|
|centriole|
|DNA integrity checkpoint|
|regulation of dendrite development|
|regulation of G1/S transition of mitotic cell cycle|
|positive regulation of synaptic transmission|
|mitotic cell cycle checkpoint|
|regulation of ubiquitin-dependent protein catabolic process|
|negative regulation of neuron projection development|
|spindle organization|
|regulation of endothelial cell migration|
|positive regulation of angiogenesis|
|regulation of cell cycle G1/S phase transition|
|regulation of cell division|
|peptidyl-serine phosphorylation|
|positive regulation of binding|
|negative regulation of cell projection organization|
|positive regulation of vasculature development|
|regulation of proteasomal protein catabolic process|
|positive regulation of I-kappaB kinase/NF-kappaB signaling|
|regulation of microtubule cytoskeleton organization|
|regulation of synaptic plasticity|
|cell cycle checkpoint|
|peptidyl-serine modification|
|negative regulation of mitotic cell cycle phase transition|
|regulation of proteolysis involved in cellular protein catabolic process|
|positive regulation of protein catabolic process|
|regulation of protein binding|
|regulation of organelle assembly|
|regulation of epithelial cell migration|
|regulation of microtubule-based process|
|negative regulation of neuron differentiation|
|negative regulation of cell cycle phase transition|
|regulation of I-kappaB kinase/NF-kappaB signaling|
|Ras protein signal transduction|
|regulation of cellular protein catabolic process|
|learning or memory|
|protein-containing complex binding|
|mitotic cell cycle phase transition|
|cell cycle phase transition|
|positive regulation of cell cycle process|
|regulation of angiogenesis|
|negative regulation of neurogenesis|
|cognition|
|negative regulation of mitotic cell cycle|
|negative regulation of nervous system development|
|small GTPase mediated signal transduction|
|regulation of vasculature development|
|negative regulation of cell cycle process|
|regulation of autophagy|
|negative regulation of cell development|
|positive regulation of proteolysis|
|protein serine/threonine kinase activity|
|positive regulation of cellular catabolic process|
|regulation of binding|
|positive regulation of cell cycle|
|regulation of protein catabolic process|
|regulation of mitotic cell cycle phase transition|
|dendrite|
|positive regulation of catabolic process|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|regulation of cell cycle phase transition|
|microtubule cytoskeleton organization|
|centrosome|
|regulation of neuron projection development|
|positive regulation of cell migration|
|positive regulation of cell motility|
|positive regulation of cellular component movement|
|regulation of cytoskeleton organization|
|positive regulation of locomotion|
|behavior|
|negative regulation of cell cycle|
|mitotic cell cycle process|
|regulation of mitotic cell cycle|
|regulation of neuron differentiation|
|microtubule-based process|
|mitotic cell cycle|
|regulation of plasma membrane bounded cell projection organization|
|negative regulation of cellular component organization|
|regulation of cell projection organization|
|negative regulation of cell differentiation|
|regulation of proteolysis|
|regulation of cellular response to stress|
|regulation of cell cycle process|
|cellular response to DNA damage stimulus|
|regulation of neurogenesis|
|regulation of cellular catabolic process|
|regulation of cell migration|
|peptidyl-amino acid modification|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|regulation of cell motility|
|regulation of nervous system development|
|regulation of cell development|
|negative regulation of developmental process|
|regulation of cellular component biogenesis|
|protein phosphorylation|
|regulation of locomotion|
|regulation of cellular component movement|
|regulation of catabolic process|
|negative regulation of cell death|
|cell cycle process|
|positive regulation of intracellular signal transduction|
|regulation of anatomical structure morphogenesis|
|cytoskeleton organization|
|regulation of cell cycle|
|negative regulation of multicellular organismal process|
|phosphorylation|
|regulation of organelle organization|
|cell cycle|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|nervous system process|
|regulation of response to stress|
|ATP binding|
|generation of neurons|
|regulation of apoptotic process|
|regulation of programmed cell death|
|positive regulation of cellular protein metabolic process|
|negative regulation of response to stimulus|
|neurogenesis|
|positive regulation of signal transduction|
|regulation of cell death|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp281|Disulfiram 4.3μM R06 exp281]]|-2.16|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|-1.82|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|-1.71|
|[[:results:exp391|Pomalidomide 20μM R07 exp391]]|-1.7|
|[[:results:exp235|Geldanamycin 0.01μM R05 exp235]]|1.74|
|[[:results:exp242|Radicicol 0.16μM R05 exp242]]|1.83|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|1.91|
|[[:results:exp236|GSK2606414 1μM R05 exp236]]|2.06|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.46|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12213
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -5.28 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PLK2 Expression in NALM6 Cells: -5.28'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>