PLRG1 [The Human Chemical-Genetic Interaction Map Project]

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======= PLRG1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PLRG1
  * **<color #00a2e8>Official Name</color>**: pleiotropic regulator 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5356|5356]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O43660|O43660]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PLRG1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PLRG1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605961|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. {ECO:0000250, ECO:0000269|PubMed:11544257}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|WD40|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Prp19 complex|
|DNA replication factor A complex|
|Cul4-RING E3 ubiquitin ligase complex|
|U2-type catalytic step 2 spliceosome|
|positive regulation of G1/S transition of mitotic cell cycle|
|positive regulation of cell cycle G1/S phase transition|
|positive regulation of mitotic cell cycle phase transition|
|catalytic step 2 spliceosome|
|positive regulation of cell cycle phase transition|
|fibrillar center|
|regulation of G1/S transition of mitotic cell cycle|
|positive regulation of mitotic cell cycle|
|protein localization to nucleus|
|regulation of cell cycle G1/S phase transition|
|nuclear membrane|
|positive regulation of cell cycle process|
|RNA splicing, via transesterification reactions with bulged adenosine as nucleophile|
|mRNA splicing, via spliceosome|
|RNA splicing, via transesterification reactions|
|positive regulation of cell cycle|
|RNA splicing|
|nuclear speck|
|regulation of mitotic cell cycle phase transition|
|regulation of cell cycle phase transition|
|mRNA processing|
|regulation of mitotic cell cycle|
|mRNA metabolic process|
|protein localization to organelle|
|regulation of cell cycle process|
|RNA processing|
|regulation of cell cycle|
|cellular protein localization|
|cellular macromolecule localization|
|RNA metabolic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|1.7|
|[[:results:exp393|Resminostat 0.5μM R07 exp393]]|1.72|
|[[:results:exp310|2-Methoxyestradiol 0.55μM R07 exp310]]|1.9|
|[[:results:exp73|LJH685 5μM R02 exp73]]|1.98|
|[[:results:exp272|CHIR-124 0.04μM R06 exp272]]|2.07|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|2.2|
|[[:results:exp318|ABT-702 5μM R07 exp318]]|2.21|
|[[:results:exp462|Cadmium 60μM R08 exp462]]|2.22|
|[[:results:exp336|Asunaprenir 3μM R07 exp336]]|2.34|
|[[:results:exp375|Lenalidomide 20μM R07 exp375]]|2.38|
|[[:results:exp341|BRD2 inhibitor II 20μM R07 exp341]]|2.47|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:psmb4|PSMB4]]|0.437|
|[[:human genes:c:cwc22|CWC22]]|0.435|
|[[:human genes:c:cdc5l|CDC5L]]|0.426|
|[[:human genes:c:cd6|CD6]]|0.425|
|[[:human genes:r:rrp7a|RRP7A]]|0.424|
|[[:human genes:n:nup160|NUP160]]|0.423|
|[[:human genes:r:rps2|RPS2]]|0.423|
|[[:human genes:c:c14orf93|C14orf93]]|0.419|
|[[:human genes:r:rrp15|RRP15]]|0.416|
|[[:human genes:z:znf148|ZNF148]]|0.414|
|[[:human genes:p:prpf8|PRPF8]]|0.409|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.408|
|[[:human genes:t:tfip11|TFIP11]]|0.405|
|[[:human genes:c:chd4|CHD4]]|0.404|
|[[:human genes:a:atp6v1c1|ATP6V1C1]]|0.403|
|[[:human genes:m:mcoln1|MCOLN1]]|0.402|
|[[:human genes:p:polr2f|POLR2F]]|0.4|
|[[:human genes:t:tceb3c|TCEB3C]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 279/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|9/28|
|blood|14/28|
|bone|11/25|
|breast|17/33|
|central nervous system|25/56|
|cervix|0/4|
|colorectal|8/17|
|esophagus|5/13|
|fibroblast|0/1|
|gastric|8/15|
|kidney|10/21|
|liver|7/20|
|lung|24/75|
|lymphocyte|6/14|
|ovary|8/26|
|pancreas|5/24|
|peripheral nervous system|8/16|
|plasma cell|7/15|
|prostate|1/1|
|skin|6/24|
|soft tissue|2/7|
|thyroid|1/2|
|upper aerodigestive|8/22|
|urinary tract|10/29|
|uterus|3/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1938
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.23 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PLRG1 Expression in NALM6 Cells: 6.23'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>