PLTP [The Human Chemical-Genetic Interaction Map Project]

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======= PLTP =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PLTP
  * **<color #00a2e8>Official Name</color>**: phospholipid transfer protein
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5360|5360]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P55058|P55058]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PLTP&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PLTP|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/172425|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is one of at least two lipid transfer proteins found in human plasma. The encoded protein transfers phospholipids from triglyceride-rich lipoproteins to high density lipoprotein (HDL). In addition to regulating the size of HDL particles, this protein may be involved in cholesterol metabolism. At least two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|LBP BPI CETP|
|LBP BPI CETP C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|phosphatidylethanolamine transfer activity|
|vitamin E biosynthetic process|
|ceramide transfer activity|
|vitamin E metabolic process|
|phosphatidylglycerol binding|
|ceramide binding|
|phosphatidic acid transfer activity|
|fat-soluble vitamin biosynthetic process|
|phosphatidylcholine transporter activity|
|phosphatidylethanolamine binding|
|diacylglycerol binding|
|ceramide transport|
|phospholipid transporter activity|
|positive regulation of cholesterol efflux|
|vitamin biosynthetic process|
|high-density lipoprotein particle remodeling|
|phosphatidic acid binding|
|high-density lipoprotein particle|
|positive regulation of cholesterol transport|
|regulation of cholesterol efflux|
|positive regulation of sterol transport|
|protein-lipid complex remodeling|
|plasma lipoprotein particle remodeling|
|phosphatidylcholine binding|
|protein-containing complex remodeling|
|lipid transporter activity|
|fat-soluble vitamin metabolic process|
|plasma lipoprotein particle organization|
|regulation of cholesterol transport|
|regulation of sterol transport|
|protein-lipid complex subunit organization|
|positive regulation of lipid transport|
|flagellated sperm motility|
|sperm motility|
|regulation of plasma lipoprotein particle levels|
|positive regulation of lipid localization|
|phospholipid transport|
|cilium or flagellum-dependent cell motility|
|cilium-dependent cell motility|
|regulation of lipid transport|
|organophosphate ester transport|
|vitamin metabolic process|
|regulation of lipid localization|
|organic hydroxy compound biosynthetic process|
|lipid transport|
|lipid localization|
|extracellular structure organization|
|organic hydroxy compound metabolic process|
|organic anion transport|
|anion transport|
|small molecule biosynthetic process|
|positive regulation of transport|
|localization of cell|
|cell motility|
|heterocycle biosynthetic process|
|lipid metabolic process|
|organic cyclic compound biosynthetic process|
|locomotion|
|ion transport|
|reproductive process|
|reproduction|
|movement of cell or subcellular component|
|amide transport|
|extracellular space|
|small molecule metabolic process|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|regulation of transport|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8029
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.99 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PLTP Expression in NALM6 Cells: 3.99'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>