PMAIP1 [The Human Chemical-Genetic Interaction Map Project]

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======= PMAIP1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PMAIP1
  * **<color #00a2e8>Official Name</color>**: phorbol-12-myristate-13-acetate-induced protein 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5366|5366]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q13794|Q13794]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PMAIP1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PMAIP1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604959|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BAK1 for binding to MCL1 and can displace BAK1 from its binding site on MCL1 (By similarity). Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11 from its binding site on MCL1. {ECO:0000250, ECO:0000269|PubMed:10807576, ECO:0000269|PubMed:15694340, ECO:0000269|PubMed:15705586, ECO:0000269|PubMed:17374615, ECO:0000269|PubMed:17389404}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|protein insertion into mitochondrial membrane involved in apoptotic signaling pathway|
|positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway|
|negative regulation of mitochondrial membrane potential|
|negative regulation of membrane potential|
|mitochondrial outer membrane permeabilization|
|positive regulation of extrinsic apoptotic signaling pathway via death domain receptors|
|positive regulation of DNA damage response, signal transduction by p53 class mediator|
|positive regulation of mitochondrial membrane permeability involved in apoptotic process|
|mitochondrial outer membrane permeabilization involved in programmed cell death|
|positive regulation of mitochondrial membrane permeability|
|protein insertion into mitochondrial membrane|
|positive regulation of signal transduction by p53 class mediator|
|release of cytochrome c from mitochondria|
|regulation of mitochondrial membrane permeability involved in apoptotic process|
|positive regulation of membrane permeability|
|positive regulation of protein oligomerization|
|regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway|
|positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway|
|positive regulation of release of cytochrome c from mitochondria|
|regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway|
|T cell homeostasis|
|regulation of DNA damage response, signal transduction by p53 class mediator|
|positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway|
|protein insertion into membrane|
|positive regulation of response to endoplasmic reticulum stress|
|positive regulation of glucose metabolic process|
|cellular response to glucose starvation|
|regulation of protein oligomerization|
|regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway|
|regulation of release of cytochrome c from mitochondria|
|positive regulation of extrinsic apoptotic signaling pathway|
|intrinsic apoptotic signaling pathway by p53 class mediator|
|response to dsRNA|
|lymphocyte homeostasis|
|regulation of extrinsic apoptotic signaling pathway via death domain receptors|
|positive regulation of intrinsic apoptotic signaling pathway|
|positive regulation of establishment of protein localization to mitochondrion|
|positive regulation of cellular carbohydrate metabolic process|
|apoptotic mitochondrial changes|
|leukocyte homeostasis|
|regulation of mitochondrial membrane potential|
|establishment of protein localization to mitochondrion|
|regulation of mitochondrial membrane permeability|
|regulation of establishment of protein localization to mitochondrion|
|protein localization to mitochondrion|
|positive regulation of carbohydrate metabolic process|
|regulation of membrane permeability|
|regulation of response to endoplasmic reticulum stress|
|activation of cysteine-type endopeptidase activity involved in apoptotic process|
|positive regulation of response to DNA damage stimulus|
|reactive oxygen species metabolic process|
|regulation of glucose metabolic process|
|positive regulation of mitochondrion organization|
|signal transduction by p53 class mediator|
|positive regulation of protein localization to membrane|
|mitochondrial membrane organization|
|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|positive regulation of small molecule metabolic process|
|regulation of cellular carbohydrate metabolic process|
|intrinsic apoptotic signaling pathway|
|cellular response to starvation|
|positive regulation of cysteine-type endopeptidase activity|
|regulation of extrinsic apoptotic signaling pathway|
|regulation of intrinsic apoptotic signaling pathway|
|mitochondrial outer membrane|
|positive regulation of endopeptidase activity|
|positive regulation of apoptotic signaling pathway|
|regulation of signal transduction by p53 class mediator|
|regulation of mitochondrion organization|
|cellular response to hypoxia|
|regulation of protein localization to membrane|
|defense response to virus|
|positive regulation of peptidase activity|
|response to starvation|
|cellular response to decreased oxygen levels|
|homeostasis of number of cells|
|regulation of carbohydrate metabolic process|
|mitochondrial transport|
|cellular response to oxygen levels|
|regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|regulation of response to DNA damage stimulus|
|cellular response to nutrient levels|
|regulation of cysteine-type endopeptidase activity|
|positive regulation of protein complex assembly|
|establishment of protein localization to membrane|
|cellular response to extracellular stimulus|
|response to virus|
|apoptotic signaling pathway|
|positive regulation of cellular protein localization|
|cellular response to external stimulus|
|response to hypoxia|
|proteasomal protein catabolic process|
|response to decreased oxygen levels|
|positive regulation of proteolysis|
|response to oxygen levels|
|regulation of apoptotic signaling pathway|
|regulation of endopeptidase activity|
|regulation of small molecule metabolic process|
|regulation of membrane potential|
|establishment of protein localization to organelle|
|mitochondrion organization|
|regulation of peptidase activity|
|regulation of protein complex assembly|
|positive regulation of establishment of protein localization|
|protein localization to membrane|
|response to nutrient levels|
|positive regulation of cellular component biogenesis|
|response to extracellular stimulus|
|regulation of cellular protein localization|
|proteolysis involved in cellular protein catabolic process|
|cellular protein catabolic process|
|positive regulation of organelle organization|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|protein catabolic process|
|positive regulation of cell death|
|regulation of proteolysis|
|protein localization to organelle|
|regulation of cellular response to stress|
|regulation of establishment of protein localization|
|positive regulation of hydrolase activity|
|cellular response to DNA damage stimulus|
|membrane organization|
|cellular macromolecule catabolic process|
|regulation of cellular localization|
|response to organic cyclic compound|
|apoptotic process|
|defense response to other organism|
|regulation of cellular component biogenesis|
|positive regulation of transport|
|positive regulation of intracellular signal transduction|
|regulation of protein localization|
|macromolecule catabolic process|
|programmed cell death|
|organonitrogen compound catabolic process|
|response to nitrogen compound|
|cell death|
|immune effector process|
|response to abiotic stimulus|
|positive regulation of cellular component organization|
|mitochondrion|
|proteolysis|
|regulation of hydrolase activity|
|regulation of organelle organization|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|positive regulation of catalytic activity|
|regulation of response to stress|
|regulation of apoptotic process|
|regulation of programmed cell death|
|cellular protein localization|
|cellular macromolecule localization|
|positive regulation of cellular protein metabolic process|
|establishment of protein localization|
|homeostatic process|
|positive regulation of signal transduction|
|regulation of cell death|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of protein metabolic process|
|organic substance catabolic process|
|positive regulation of molecular function|
|cellular catabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|establishment of localization in cell|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp8|Brefeldin A 0.02μM R00 exp8]]|-2.26|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|-2.11|
|[[:results:exp458|Bisphenol S 100μM R08 exp458]]|1.71|
|[[:results:exp150|SGC0649 7μM R03 exp150]]|1.72|
|[[:results:exp525|Sulforaphane 9μM R08 exp525]]|1.73|
|[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|1.74|
|[[:results:exp526|Sulforaphane 9μM R08 exp526 no dilution day6]]|1.8|
|[[:results:exp455|Benzoate 10000μM R08 exp455]]|1.81|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|1.81|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|1.82|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|2|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|2.01|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|2.06|
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|2.13|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|2.14|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|2.17|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|2.22|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|2.22|
|[[:results:exp414|Tozasertib 0.1μM R07 exp414]]|2.23|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|2.3|
|[[:results:exp431|Rotenone 0.07μM R08 exp431]]|2.41|
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|2.42|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|2.59|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|2.67|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|2.89|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|3.44|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|4.26|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|4.75|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:b:bcl2l11|BCL2L11]]|0.556|
|[[:human genes:p:prim1|PRIM1]]|0.477|
|[[:human genes:m:march5|MARCH5]]|0.458|
|[[:human genes:z:zfc3h1|ZFC3H1]]|0.45|
|[[:human genes:b:bak1|BAK1]]|0.431|
|[[:human genes:p:ptma|PTMA]]|0.43|
|[[:human genes:d:dgkd|DGKD]]|0.427|
|[[:human genes:r:rictor|RICTOR]]|0.426|
|[[:human genes:p:pcif1|PCIF1]]|0.416|
|[[:human genes:c:cd19|CD19]]|0.412|
|[[:human genes:p:prrc2c|PRRC2C]]|0.41|
|[[:human genes:e:eif4a1|EIF4A1]]|0.408|
|[[:human genes:w:wdr37|WDR37]]|0.405|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 19078
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.9 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PMAIP1 Expression in NALM6 Cells: 5.9'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>