PML [The Human Chemical-Genetic Interaction Map Project]

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======= PML =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PML
  * **<color #00a2e8>Official Name</color>**: promyelocytic leukemia
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5371|5371]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P29590|P29590]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PML&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PML|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/102578|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions; all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|zf-B box|
|DUF3583|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|common-partner SMAD protein phosphorylation|
|PML body organization|
|extrinsic component of endoplasmic reticulum membrane|
|fibroblast migration|
|SUMO binding|
|negative regulation of viral release from host cell|
|negative regulation of interleukin-1 beta secretion|
|nuclear body organization|
|intrinsic apoptotic signaling pathway in response to oxidative stress|
|retinoic acid receptor signaling pathway|
|negative regulation of interleukin-1 secretion|
|cell death in response to oxidative stress|
|entrainment of circadian clock by photoperiod|
|endoplasmic reticulum calcium ion homeostasis|
|maintenance of protein location in nucleus|
|branching involved in mammary gland duct morphogenesis|
|photoperiodism|
|heterochromatin|
|negative regulation of interleukin-1 beta production|
|entrainment of circadian clock|
|cellular response to interleukin-4|
|intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|
|response to interleukin-4|
|mammary gland duct morphogenesis|
|regulation of viral release from host cell|
|cellular senescence|
|intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress|
|negative regulation of interleukin-1 production|
|maintenance of protein localization in organelle|
|mammary gland morphogenesis|
|regulation of interleukin-1 beta secretion|
|negative regulation of ubiquitin-dependent protein catabolic process|
|positive regulation of extrinsic apoptotic signaling pathway|
|positive regulation of telomere maintenance|
|intrinsic apoptotic signaling pathway by p53 class mediator|
|positive regulation of fibroblast proliferation|
|SMAD binding|
|regulation of interleukin-1 secretion|
|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|
|response to gamma radiation|
|signal transduction involved in mitotic cell cycle checkpoint|
|signal transduction involved in mitotic DNA damage checkpoint|
|signal transduction involved in mitotic G1 DNA damage checkpoint|
|signal transduction involved in mitotic DNA integrity checkpoint|
|intracellular signal transduction involved in G1 DNA damage checkpoint|
|mammary gland epithelium development|
|circadian regulation of gene expression|
|mitotic G1 DNA damage checkpoint|
|mitotic G1/S transition checkpoint|
|cell aging|
|G1 DNA damage checkpoint|
|negative regulation of cytokine secretion|
|intrinsic apoptotic signaling pathway in response to DNA damage|
|signal transduction involved in DNA integrity checkpoint|
|signal transduction involved in DNA damage checkpoint|
|negative regulation of proteolysis involved in cellular protein catabolic process|
|interferon-gamma-mediated signaling pathway|
|signal transduction involved in cell cycle checkpoint|
|maintenance of protein location in cell|
|regulation of double-strand break repair|
|DNA damage response, signal transduction by p53 class mediator|
|positive regulation of cell cycle arrest|
|negative regulation of viral life cycle|
|regulation of interleukin-1 beta production|
|regulation of fibroblast proliferation|
|regulation of telomere maintenance|
|activation of cysteine-type endopeptidase activity involved in apoptotic process|
|negative regulation of cellular protein catabolic process|
|regulation of interleukin-1 production|
|mitotic DNA damage checkpoint|
|protein import into nucleus|
|maintenance of location in cell|
|cellular response to leukemia inhibitory factor|
|response to leukemia inhibitory factor|
|extrinsic apoptotic signaling pathway|
|negative regulation of viral process|
|gland morphogenesis|
|regulation of calcium ion transport into cytosol|
|PML body|
|negative regulation of G1/S transition of mitotic cell cycle|
|transforming growth factor beta receptor signaling pathway|
|negative regulation of angiogenesis|
|mitotic DNA integrity checkpoint|
|signal transduction in response to DNA damage|
|negative regulation of blood vessel morphogenesis|
|maintenance of protein location|
|negative regulation of cell cycle G1/S phase transition|
|regulation of cell cycle arrest|
|nuclear chromosome, telomeric region|
|nuclear matrix|
|import into nucleus|
|regulation of circadian rhythm|
|negative regulation of vasculature development|
|signal transduction by p53 class mediator|
|regulation of DNA repair|
|mammary gland development|
|branching morphogenesis of an epithelial tube|
|negative regulation of protein secretion|
|DNA damage checkpoint|
|nucleus organization|
|negative regulation of protein catabolic process|
|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|negative regulation of peptide secretion|
|circadian rhythm|
|protein import|
|response to UV|
|DNA integrity checkpoint|
|regulation of viral life cycle|
|cell cycle arrest|
|intrinsic apoptotic signaling pathway|
|response to ionizing radiation|
|regulation of G1/S transition of mitotic cell cycle|
|positive regulation of cysteine-type endopeptidase activity|
|early endosome membrane|
|mitotic cell cycle checkpoint|
|regulation of ubiquitin-dependent protein catabolic process|
|regulation of extrinsic apoptotic signaling pathway|
|cellular response to transforming growth factor beta stimulus|
|morphogenesis of a branching epithelium|
|cellular response to interferon-gamma|
|protein localization to nucleus|
|response to transforming growth factor beta|
|intracellular receptor signaling pathway|
|maintenance of location|
|regulation of cell cycle G1/S phase transition|
|morphogenesis of a branching structure|
|ameboidal-type cell migration|
|positive regulation of endopeptidase activity|
|positive regulation of apoptotic signaling pathway|
|positive regulation of chromosome organization|
|regulation of signal transduction by p53 class mediator|
|negative regulation of protein transport|
|response to interferon-gamma|
|negative regulation of cell growth|
|negative regulation of establishment of protein localization|
|defense response to virus|
|positive regulation of peptidase activity|
|cell cycle checkpoint|
|positive regulation of DNA metabolic process|
|transmembrane receptor protein serine/threonine kinase signaling pathway|
|negative regulation of secretion by cell|
|regulation of cytokine secretion|
|regulation of viral process|
|negative regulation of mitotic cell cycle phase transition|
|regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|negative regulation of multi-organism process|
|regulation of proteolysis involved in cellular protein catabolic process|
|regulation of response to DNA damage stimulus|
|myeloid cell differentiation|
|regulation of symbiosis, encompassing mutualism through parasitism|
|negative regulation of cell cycle phase transition|
|negative regulation of secretion|
|cellular response to oxidative stress|
|regulation of cysteine-type endopeptidase activity|
|negative regulation of growth|
|cell fate commitment|
|regulation of cellular protein catabolic process|
|regulation of calcium ion transport|
|negative regulation of cellular catabolic process|
|response to endoplasmic reticulum stress|
|nucleocytoplasmic transport|
|nuclear transport|
|negative regulation of cytokine production|
|rhythmic process|
|aging|
|response to virus|
|transcription coactivator activity|
|apoptotic signaling pathway|
|positive regulation of cell cycle process|
|regulation of angiogenesis|
|ubiquitin protein ligase binding|
|response to light stimulus|
|epithelial tube morphogenesis|
|negative regulation of mitotic cell cycle|
|negative regulation of catabolic process|
|regulation of vasculature development|
|negative regulation of locomotion|
|proteasome-mediated ubiquitin-dependent protein catabolic process|
|negative regulation of cell cycle process|
|response to hypoxia|
|regulation of chromosome organization|
|proteasomal protein catabolic process|
|negative regulation of proteolysis|
|regulation of DNA metabolic process|
|response to decreased oxygen levels|
|positive regulation of proteolysis|
|positive regulation of cell cycle|
|response to oxygen levels|
|regulation of protein catabolic process|
|regulation of metal ion transport|
|response to oxidative stress|
|regulation of apoptotic signaling pathway|
|gland development|
|regulation of mitotic cell cycle phase transition|
|regulation of cell growth|
|regulation of endopeptidase activity|
|establishment of protein localization to organelle|
|morphogenesis of an epithelium|
|cellular calcium ion homeostasis|
|response to radiation|
|regulation of peptidase activity|
|regulation of cell cycle phase transition|
|calcium ion homeostasis|
|regulation of protein secretion|
|cellular divalent inorganic cation homeostasis|
|negative regulation of transport|
|divalent inorganic cation homeostasis|
|regulation of peptide secretion|
|cellular response to growth factor stimulus|
|ubiquitin-dependent protein catabolic process|
|response to growth factor|
|modification-dependent protein catabolic process|
|modification-dependent macromolecule catabolic process|
|cellular metal ion homeostasis|
|hemopoiesis|
|tissue morphogenesis|
|negative regulation of cell cycle|
|proteolysis involved in cellular protein catabolic process|
|mitotic cell cycle process|
|hematopoietic or lymphoid organ development|
|cellular protein catabolic process|
|positive regulation of organelle organization|
|metal ion homeostasis|
|regulation of mitotic cell cycle|
|cellular cation homeostasis|
|positive regulation of apoptotic process|
|cellular ion homeostasis|
|immune system development|
|positive regulation of programmed cell death|
|tube morphogenesis|
|regulation of growth|
|cytokine-mediated signaling pathway|
|negative regulation of cell population proliferation|
|regulation of cell adhesion|
|protein catabolic process|
|mitotic cell cycle|
|regulation of cytokine production|
|positive regulation of cell death|
|regulation of ion transport|
|viral process|
|cation homeostasis|
|regulation of protein transport|
|enzyme linked receptor protein signaling pathway|
|inorganic ion homeostasis|
|regulation of proteolysis|
|protein localization to organelle|
|regulation of cellular response to stress|
|regulation of peptide transport|
|cellular chemical homeostasis|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of cell cycle process|
|innate immune response|
|positive regulation of hydrolase activity|
|cellular response to DNA damage stimulus|
|regulation of multi-organism process|
|symbiotic process|
|ion homeostasis|
|regulation of secretion|
|interspecies interaction between organisms|
|regulation of cellular catabolic process|
|zinc ion binding|
|tube development|
|nucleolus|
|protein homodimerization activity|
|cellular homeostasis|
|cellular macromolecule catabolic process|
|regulation of cellular localization|
|positive regulation of cell population proliferation|
|apoptotic process|
|negative regulation of developmental process|
|defense response to other organism|
|animal organ morphogenesis|
|cell migration|
|protein phosphorylation|
|regulation of locomotion|
|intracellular protein transport|
|regulation of catabolic process|
|cell cycle process|
|cellular response to cytokine stimulus|
|regulation of protein localization|
|negative regulation of cellular protein metabolic process|
|macromolecule catabolic process|
|programmed cell death|
|organonitrogen compound catabolic process|
|regulation of anatomical structure morphogenesis|
|localization of cell|
|cell motility|
|cell death|
|immune effector process|
|response to cytokine|
|negative regulation of protein metabolic process|
|chemical homeostasis|
|epithelium development|
|response to abiotic stimulus|
|regulation of cell cycle|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|positive regulation of cellular component organization|
|cellular response to endogenous stimulus|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|proteolysis|
|regulation of hydrolase activity|
|phosphorylation|
|regulation of organelle organization|
|response to other organism|
|response to external biotic stimulus|
|locomotion|
|response to biotic stimulus|
|negative regulation of RNA metabolic process|
|cell cycle|
|defense response|
|negative regulation of cellular macromolecule biosynthetic process|
|positive regulation of catalytic activity|
|negative regulation of nucleobase-containing compound metabolic process|
|regulation of protein phosphorylation|
|DNA binding|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|regulation of response to stress|
|protein transport|
|negative regulation of cellular biosynthetic process|
|intracellular transport|
|peptide transport|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|movement of cell or subcellular component|
|protein-containing complex assembly|
|regulation of programmed cell death|
|amide transport|
|cellular protein localization|
|regulation of phosphorylation|
|cellular macromolecule localization|
|positive regulation of cellular protein metabolic process|
|establishment of protein localization|
|regulation of cell population proliferation|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|homeostatic process|
|positive regulation of signal transduction|
|regulation of cell death|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|tissue development|
|organic substance catabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|cellular catabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|establishment of localization in cell|
|regulation of protein modification process|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|regulation of transport|
|immune response|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp418|Tunicamycin 0.04μM R07 exp418]]|1.79|
|[[:results:exp526|Sulforaphane 9μM R08 exp526 no dilution day6]]|1.89|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|1.94|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|1.95|
|[[:results:exp453|B02 10μM R08 exp453]]|2.24|
|[[:results:exp356|Docosahexaenoic-acid 50μM R07 exp356]]|2.49|
|[[:results:exp525|Sulforaphane 9μM R08 exp525]]|2.51|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|2.96|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|3.41|
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|6.61|
|[[:results:exp299|Talazoparib 0.006μM R06 exp299]]|8.22|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rmi1|RMI1]]|0.636|
|[[:human genes:r:rmi2|RMI2]]|0.631|
|[[:human genes:b:blm|BLM]]|0.617|
|[[:human genes:t:top3a|TOP3A]]|0.54|
|[[:human genes:s:slfn11|SLFN11]]|0.463|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|1/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7297
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.8 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PML Expression in NALM6 Cells: 5.8'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>