PMM2 [The Human Chemical-Genetic Interaction Map Project]

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======= PMM2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PMM2
  * **<color #00a2e8>Official Name</color>**: phosphomannomutase 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5373|5373]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O15305|O15305]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PMM2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PMM2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601785|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene catalyzes the isomerization of mannose 6-phosphate to mannose 1-phosphate, which is a precursor to GDP-mannose necessary for the synthesis of dolichol-P-oligosaccharides. Mutations in this gene have been shown to cause defects in glycoprotein biosynthesis, which manifests as carbohydrate-deficient glycoprotein syndrome type I. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions. {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PMM|
|Hydrolase 3|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|phosphomannomutase activity|
|GDP-mannose biosynthetic process|
|GDP-mannose metabolic process|
|mannose metabolic process|
|nucleotide-sugar biosynthetic process|
|nucleotide-sugar metabolic process|
|protein N-linked glycosylation|
|protein targeting to ER|
|establishment of protein localization to endoplasmic reticulum|
|protein localization to endoplasmic reticulum|
|hexose metabolic process|
|monosaccharide metabolic process|
|protein glycosylation|
|macromolecule glycosylation|
|glycosylation|
|glycoprotein biosynthetic process|
|protein targeting|
|neuronal cell body|
|glycoprotein metabolic process|
|establishment of protein localization to organelle|
|carbohydrate metabolic process|
|nucleobase-containing small molecule metabolic process|
|carbohydrate derivative biosynthetic process|
|protein localization to organelle|
|intracellular protein transport|
|carbohydrate derivative metabolic process|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|organic cyclic compound biosynthetic process|
|organonitrogen compound biosynthetic process|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|cellular nitrogen compound biosynthetic process|
|cellular macromolecule biosynthetic process|
|small molecule metabolic process|
|macromolecule biosynthetic process|
|establishment of localization in cell|
|nitrogen compound transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|-3.4|
|[[:results:exp176|Apcin 50 to 100μM on day4 R04 exp176]]|-2.36|
|[[:results:exp122|Golgicide-A 4μM R03 exp122]]|-2.11|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|-2.1|
|[[:results:exp236|GSK2606414 1μM R05 exp236]]|-2.07|
|[[:results:exp245|UM0011500 5μM R05 exp245]]|-2.07|
|[[:results:exp421|VHL-ligand-1 20μM R07 exp421]]|-2.06|
|[[:results:exp27|Pimelic-diphenylamide-106 0.5μM R00 exp27]]|-2.05|
|[[:results:exp115|A-366 10μM R03 exp115]]|-2.03|
|[[:results:exp47|Lapatinib 5μM R01 exp47]]|-2.02|
|[[:results:exp54|Taxol 0.002μM R01 exp54]]|-2.02|
|[[:results:exp136|MS094 2μM R03 exp136]]|-1.99|
|[[:results:exp191|Hypoxia 5%O2 R04 exp191]]|-1.98|
|[[:results:exp375|Lenalidomide 20μM R07 exp375]]|-1.94|
|[[:results:exp249|Vinorelbine 0.001μM R05 exp249]]|-1.93|
|[[:results:exp187|proTAME 5μM R04 exp187]]|-1.91|
|[[:results:exp184|Ixabepilone 0.004 to 0.005μM on day4 R04 exp184]]|-1.9|
|[[:results:exp100|NFN1 1μM R03 exp100]]|-1.9|
|[[:results:exp130|JQ1 0.01μM R03 exp130]]|-1.89|
|[[:results:exp248|UM0131023 0.05μM R05 exp248]]|-1.87|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|-1.86|
|[[:results:exp223|Cabazitaxel 0.001μM R05 exp223]]|-1.85|
|[[:results:exp12|Chloramphenicol 2μM R00 exp12]]|-1.85|
|[[:results:exp10|CCCP 0.1μM R00 exp10]]|-1.82|
|[[:results:exp233|EPZ-5676 30μM R05 exp233]]|-1.81|
|[[:results:exp58|UM131593 0.1μM R01 exp58]]|-1.81|
|[[:results:exp143|Phenformin 20μM R03 exp143]]|-1.77|
|[[:results:exp405|Tenofovir 10μM R07 exp405]]|-1.77|
|[[:results:exp142|OICR-9429 10μM R03 exp142]]|-1.73|
|[[:results:exp210|LB-100 2μM R05 exp210]]|-1.72|
|[[:results:exp18|Doxycycline 10μM R00 exp18]]|-1.7|
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|1.72|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|1.73|
|[[:results:exp82|Torin1 0.08μM R02 exp82]]|1.73|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|1.75|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|1.82|
|[[:results:exp513|ONC212 0.15μM R08 exp513]]|1.82|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|1.86|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|1.91|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|1.99|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|2.01|
|[[:results:exp64|Nocodazole 0.2μM R02 exp64]]|2.04|
|[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|2.13|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|2.14|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|2.17|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|2.2|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|2.22|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|2.26|
|[[:results:exp8|Brefeldin A 0.02μM R00 exp8]]|2.29|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|2.31|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|2.34|
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|2.35|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|2.35|
|[[:results:exp539|42°C R08 exp539]]|2.73|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|2.88|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:d:dpagt1|DPAGT1]]|0.763|
|[[:human genes:t:triap1|TRIAP1]]|0.754|
|[[:human genes:t:thg1l|THG1L]]|0.754|
|[[:human genes:a:alg1|ALG1]]|0.751|
|[[:human genes:g:gmppb|GMPPB]]|0.746|
|[[:human genes:u:uap1|UAP1]]|0.695|
|[[:human genes:g:gfpt1|GFPT1]]|0.69|
|[[:human genes:a:alg2|ALG2]]|0.686|
|[[:human genes:r:rnmt|RNMT]]|0.674|
|[[:human genes:a:atxn10|ATXN10]]|0.661|
|[[:human genes:t:tamm41|TAMM41]]|0.653|
|[[:human genes:r:rpe|RPE]]|0.645|
|[[:human genes:r:rptor|RPTOR]]|0.644|
|[[:human genes:a:alg5|ALG5]]|0.642|
|[[:human genes:s:slc25a26|SLC25A26]]|0.642|
|[[:human genes:s:srp14|SRP14]]|0.641|
|[[:human genes:t:trmt5|TRMT5]]|0.64|
|[[:human genes:a:alg13|ALG13]]|0.637|
|[[:human genes:r:romo1|ROMO1]]|0.635|
|[[:human genes:u:uhrf1|UHRF1]]|0.631|
|[[:human genes:d:dohh|DOHH]]|0.623|
|[[:human genes:r:rpp21|RPP21]]|0.619|
|[[:human genes:t:taz|TAZ]]|0.614|
|[[:human genes:r:rtcb|RTCB]]|0.614|
|[[:human genes:g:gtf3c3|GTF3C3]]|0.613|
|[[:human genes:c:crls1|CRLS1]]|0.613|
|[[:human genes:d:dad1|DAD1]]|0.607|
|[[:human genes:h:hars|HARS]]|0.607|
|[[:human genes:p:pelo|PELO]]|0.607|
|[[:human genes:n:nae1|NAE1]]|0.604|
|[[:human genes:u:utp23|UTP23]]|0.604|
|[[:human genes:e:eny2|ENY2]]|0.603|
|[[:human genes:g:gnb1l|GNB1L]]|0.601|
|[[:human genes:v:vezt|VEZT]]|0.6|
|[[:human genes:m:med16|MED16]]|0.597|
|[[:human genes:a:alg14|ALG14]]|0.588|
|[[:human genes:r:rpia|RPIA]]|0.588|
|[[:human genes:a:alg6|ALG6]]|0.587|
|[[:human genes:o:oraov1|ORAOV1]]|0.581|
|[[:human genes:g:gtf3c4|GTF3C4]]|0.581|
|[[:human genes:a:adsl|ADSL]]|0.578|
|[[:human genes:t:tsen54|TSEN54]]|0.578|
|[[:human genes:a:aasdhppt|AASDHPPT]]|0.576|
|[[:human genes:e:exoc4|EXOC4]]|0.573|
|[[:human genes:h:hspd1|HSPD1]]|0.571|
|[[:human genes:a:atp5j|ATP5J]]|0.571|
|[[:human genes:c:ccdc101|CCDC101]]|0.568|
|[[:human genes:h:haus8|HAUS8]]|0.568|
|[[:human genes:a:aars|AARS]]|0.565|
|[[:human genes:g:gemin8|GEMIN8]]|0.56|
|[[:human genes:t:tti1|TTI1]]|0.558|
|[[:human genes:t:tti2|TTI2]]|0.557|
|[[:human genes:g:gtf3c2|GTF3C2]]|0.557|
|[[:human genes:t:tbca|TBCA]]|0.557|
|[[:human genes:o:opa1|OPA1]]|0.556|
|[[:human genes:u:ube2g2|UBE2G2]]|0.556|
|[[:human genes:e:eprs|EPRS]]|0.553|
|[[:human genes:c:cbfb|CBFB]]|0.552|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.551|
|[[:human genes:l:lsm10|LSM10]]|0.551|
|[[:human genes:b:bap1|BAP1]]|0.55|
|[[:human genes:t:trmt10a|TRMT10A]]|0.549|
|[[:human genes:p:pam16|PAM16]]|0.549|
|[[:human genes:p:ppcs|PPCS]]|0.547|
|[[:human genes:t:trnt1|TRNT1]]|0.547|
|[[:human genes:t:ttc4|TTC4]]|0.546|
|[[:human genes:p:ppp2r3c|PPP2R3C]]|0.545|
|[[:human genes:z:zrsr2|ZRSR2]]|0.545|
|[[:human genes:n:nsmce1|NSMCE1]]|0.545|
|[[:human genes:w:wdr24|WDR24]]|0.543|
|[[:human genes:d:ddost|DDOST]]|0.541|
|[[:human genes:d:dhps|DHPS]]|0.541|
|[[:human genes:t:tmem41b|TMEM41B]]|0.541|
|[[:human genes:c:csnk2b|CSNK2B]]|0.541|
|[[:human genes:a:atp5o|ATP5O]]|0.54|
|[[:human genes:h:hccs|HCCS]]|0.54|
|[[:human genes:m:mtor|MTOR]]|0.538|
|[[:human genes:c:chchd4|CHCHD4]]|0.536|
|[[:human genes:p:pggt1b|PGGT1B]]|0.536|
|[[:human genes:t:thoc6|THOC6]]|0.535|
|[[:human genes:t:txnrd1|TXNRD1]]|0.532|
|[[:human genes:a:atp5b|ATP5B]]|0.531|
|[[:human genes:g:gemin5|GEMIN5]]|0.53|
|[[:human genes:p:ppa2|PPA2]]|0.529|
|[[:human genes:g:gtf2a2|GTF2A2]]|0.528|
|[[:human genes:s:sec62|SEC62]]|0.528|
|[[:human genes:t:ten1|TEN1]]|0.528|
|[[:human genes:u:uba3|UBA3]]|0.528|
|[[:human genes:u:ube2j1|UBE2J1]]|0.527|
|[[:human genes:d:dhrsx|DHRSX]]|0.526|
|[[:human genes:s:sdha|SDHA]]|0.526|
|[[:human genes:g:gtf3c6|GTF3C6]]|0.526|
|[[:human genes:d:dpf2|DPF2]]|0.525|
|[[:human genes:a:atp2a2|ATP2A2]]|0.522|
|[[:human genes:s:srd5a3|SRD5A3]]|0.521|
|[[:human genes:m:mbtps2|MBTPS2]]|0.521|
|[[:human genes:d:ddx20|DDX20]]|0.52|
|[[:human genes:d:dolk|DOLK]]|0.519|
|[[:human genes:g:gtf3a|GTF3A]]|0.517|
|[[:human genes:v:vmp1|VMP1]]|0.516|
|[[:human genes:s:slc25a19|SLC25A19]]|0.515|
|[[:human genes:t:telo2|TELO2]]|0.515|
|[[:human genes:e:eno1|ENO1]]|0.515|
|[[:human genes:t:timm13|TIMM13]]|0.515|
|[[:human genes:f:fnta|FNTA]]|0.515|
|[[:human genes:l:lsm11|LSM11]]|0.514|
|[[:human genes:f:fh|FH]]|0.513|
|[[:human genes:o:osgep|OSGEP]]|0.512|
|[[:human genes:r:rpn1|RPN1]]|0.512|
|[[:human genes:e:elac2|ELAC2]]|0.511|
|[[:human genes:a:atp5d|ATP5D]]|0.511|
|[[:human genes:s:srp72|SRP72]]|0.51|
|[[:human genes:m:mapk14|MAPK14]]|0.509|
|[[:human genes:p:plaa|PLAA]]|0.508|
|[[:human genes:y:yars|YARS]]|0.503|
|[[:human genes:p:polr3h|POLR3H]]|0.503|
|[[:human genes:a:atp5h|ATP5H]]|0.502|
|[[:human genes:a:apaf1|APAF1]]|0.501|
|[[:human genes:s:sec61g|SEC61G]]|0.5|
|[[:human genes:c:casp9|CASP9]]|0.5|
|[[:human genes:a:atp5a1|ATP5A1]]|0.5|
|[[:human genes:e:eif4e|EIF4E]]|0.499|
|[[:human genes:m:mars|MARS]]|0.499|
|[[:human genes:p:ppp4c|PPP4C]]|0.496|
|[[:human genes:d:dnlz|DNLZ]]|0.495|
|[[:human genes:u:uxt|UXT]]|0.495|
|[[:human genes:e:eif3f|EIF3F]]|0.49|
|[[:human genes:d:dr1|DR1]]|0.49|
|[[:human genes:m:mllt1|MLLT1]]|0.487|
|[[:human genes:t:tgs1|TGS1]]|0.487|
|[[:human genes:a:atic|ATIC]]|0.487|
|[[:human genes:r:rad1|RAD1]]|0.486|
|[[:human genes:c:cep57|CEP57]]|0.486|
|[[:human genes:n:nars|NARS]]|0.486|
|[[:human genes:e:exoc3|EXOC3]]|0.485|
|[[:human genes:m:meaf6|MEAF6]]|0.484|
|[[:human genes:s:ssb|SSB]]|0.482|
|[[:human genes:g:gfer|GFER]]|0.482|
|[[:human genes:v:vrk1|VRK1]]|0.481|
|[[:human genes:m:med4|MED4]]|0.479|
|[[:human genes:c:c17orf89|C17orf89]]|0.479|
|[[:human genes:t:tmed10|TMED10]]|0.478|
|[[:human genes:p:pdss1|PDSS1]]|0.478|
|[[:human genes:c:ctdnep1|CTDNEP1]]|0.477|
|[[:human genes:t:timm22|TIMM22]]|0.477|
|[[:human genes:w:wdr82|WDR82]]|0.477|
|[[:human genes:u:ube2k|UBE2K]]|0.477|
|[[:human genes:m:mrps14|MRPS14]]|0.476|
|[[:human genes:c:cycs|CYCS]]|0.476|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.475|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.475|
|[[:human genes:c:cox16|COX16]]|0.475|
|[[:human genes:d:dnajc3|DNAJC3]]|0.475|
|[[:human genes:r:rabggtb|RABGGTB]]|0.475|
|[[:human genes:m:mrps33|MRPS33]]|0.473|
|[[:human genes:t:tsen34|TSEN34]]|0.472|
|[[:human genes:t:tmem242|TMEM242]]|0.471|
|[[:human genes:c:cdipt|CDIPT]]|0.471|
|[[:human genes:d:ddx55|DDX55]]|0.47|
|[[:human genes:y:yars2|YARS2]]|0.47|
|[[:human genes:d:ddx39a|DDX39A]]|0.47|
|[[:human genes:t:tbcb|TBCB]]|0.47|
|[[:human genes:m:mis18a|MIS18A]]|0.469|
|[[:human genes:z:znf259|ZNF259]]|0.468|
|[[:human genes:t:trmt61a|TRMT61A]]|0.467|
|[[:human genes:t:tpk1|TPK1]]|0.467|
|[[:human genes:t:taf1a|TAF1A]]|0.467|
|[[:human genes:g:gemin6|GEMIN6]]|0.466|
|[[:human genes:c:cct7|CCT7]]|0.466|
|[[:human genes:m:mrps34|MRPS34]]|0.465|
|[[:human genes:b:bcs1l|BCS1L]]|0.465|
|[[:human genes:n:nsd1|NSD1]]|0.464|
|[[:human genes:p:pdap1|PDAP1]]|0.464|
|[[:human genes:p:pgm3|PGM3]]|0.464|
|[[:human genes:m:mrps5|MRPS5]]|0.464|
|[[:human genes:s:srp68|SRP68]]|0.463|
|[[:human genes:p:pisd|PISD]]|0.463|
|[[:human genes:s:stt3a|STT3A]]|0.462|
|[[:human genes:t:txnl4b|TXNL4B]]|0.462|
|[[:human genes:t:tprkb|TPRKB]]|0.462|
|[[:human genes:u:urm1|URM1]]|0.462|
|[[:human genes:w:wdr59|WDR59]]|0.462|
|[[:human genes:i:irf2bp2|IRF2BP2]]|0.461|
|[[:human genes:s:snapc5|SNAPC5]]|0.461|
|[[:human genes:s:sars2|SARS2]]|0.459|
|[[:human genes:r:rpusd4|RPUSD4]]|0.459|
|[[:human genes:p:ppp6c|PPP6C]]|0.458|
|[[:human genes:b:bak1|BAK1]]|0.458|
|[[:human genes:c:cbx3|CBX3]]|0.458|
|[[:human genes:e:elp3|ELP3]]|0.457|
|[[:human genes:r:rft1|RFT1]]|0.457|
|[[:human genes:g:gpn2|GPN2]]|0.457|
|[[:human genes:m:mrpl23|MRPL23]]|0.457|
|[[:human genes:m:med23|MED23]]|0.455|
|[[:human genes:t:tufm|TUFM]]|0.455|
|[[:human genes:t:tbp|TBP]]|0.455|
|[[:human genes:r:rfk|RFK]]|0.454|
|[[:human genes:e:eef1e1|EEF1E1]]|0.454|
|[[:human genes:p:polr3b|POLR3B]]|0.452|
|[[:human genes:m:mrpl53|MRPL53]]|0.451|
|[[:human genes:m:mrps18a|MRPS18A]]|0.45|
|[[:human genes:a:alg8|ALG8]]|0.45|
|[[:human genes:s:srprb|SRPRB]]|0.45|
|[[:human genes:k:kdsr|KDSR]]|0.449|
|[[:human genes:a:atp5c1|ATP5C1]]|0.449|
|[[:human genes:t:tkt|TKT]]|0.449|
|[[:human genes:m:mrps6|MRPS6]]|0.449|
|[[:human genes:d:ddx6|DDX6]]|0.449|
|[[:human genes:p:polr3c|POLR3C]]|0.447|
|[[:human genes:f:fev|FEV]]|0.446|
|[[:human genes:o:otud5|OTUD5]]|0.445|
|[[:human genes:c:ctc1|CTC1]]|0.445|
|[[:human genes:t:tomm40|TOMM40]]|0.444|
|[[:human genes:d:dars2|DARS2]]|0.444|
|[[:human genes:s:sec16a|SEC16A]]|0.443|
|[[:human genes:m:mrpl21|MRPL21]]|0.443|
|[[:human genes:g:gatc|GATC]]|0.442|
|[[:human genes:p:pyroxd1|PYROXD1]]|0.442|
|[[:human genes:s:spcs2|SPCS2]]|0.441|
|[[:human genes:x:xpo6|XPO6]]|0.44|
|[[:human genes:r:rbm14|RBM14]]|0.44|
|[[:human genes:w:wbscr16|WBSCR16]]|0.44|
|[[:human genes:c:crcp|CRCP]]|0.44|
|[[:human genes:u:ube2m|UBE2M]]|0.44|
|[[:human genes:e:eif1ax|EIF1AX]]|0.439|
|[[:human genes:k:kctd5|KCTD5]]|0.439|
|[[:human genes:w:wdr1|WDR1]]|0.437|
|[[:human genes:g:g6pd|G6PD]]|0.436|
|[[:human genes:b:brwd1|BRWD1]]|0.436|
|[[:human genes:d:ddx1|DDX1]]|0.436|
|[[:human genes:l:lamtor5|LAMTOR5]]|0.436|
|[[:human genes:d:dap3|DAP3]]|0.435|
|[[:human genes:s:suv420h1|SUV420H1]]|0.435|
|[[:human genes:e:elp2|ELP2]]|0.434|
|[[:human genes:e:eed|EED]]|0.433|
|[[:human genes:m:mrpl36|MRPL36]]|0.432|
|[[:human genes:f:faf2|FAF2]]|0.432|
|[[:human genes:t:tle4|TLE4]]|0.43|
|[[:human genes:g:gemin7|GEMIN7]]|0.43|
|[[:human genes:c:cars|CARS]]|0.429|
|[[:human genes:s:sec63|SEC63]]|0.429|
|[[:human genes:s:sco2|SCO2]]|0.429|
|[[:human genes:d:dhx29|DHX29]]|0.428|
|[[:human genes:p:ptchd3|PTCHD3]]|0.427|
|[[:human genes:m:mrps2|MRPS2]]|0.426|
|[[:human genes:l:lamtor4|LAMTOR4]]|0.426|
|[[:human genes:n:nxt1|NXT1]]|0.424|
|[[:human genes:k:kdm8|KDM8]]|0.423|
|[[:human genes:m:mrps16|MRPS16]]|0.423|
|[[:human genes:g:gfm1|GFM1]]|0.423|
|[[:human genes:t:trim28|TRIM28]]|0.423|
|[[:human genes:s:sox7|SOX7]]|0.422|
|[[:human genes:c:cinp|CINP]]|0.422|
|[[:human genes:n:n6amt1|N6AMT1]]|0.421|
|[[:human genes:t:timm10|TIMM10]]|0.421|
|[[:human genes:t:thoc3|THOC3]]|0.421|
|[[:human genes:s:slc35b1|SLC35B1]]|0.42|
|[[:human genes:l:lsmd1|LSMD1]]|0.42|
|[[:human genes:m:mfn1|MFN1]]|0.419|
|[[:human genes:d:dctn6|DCTN6]]|0.418|
|[[:human genes:s:serf2|SERF2]]|0.418|
|[[:human genes:u:uqcrc2|UQCRC2]]|0.418|
|[[:human genes:t:tpi1|TPI1]]|0.418|
|[[:human genes:z:zfp91|ZFP91]]|0.418|
|[[:human genes:d:dhdds|DHDDS]]|0.417|
|[[:human genes:m:mrps11|MRPS11]]|0.416|
|[[:human genes:e:eftud1|EFTUD1]]|0.415|
|[[:human genes:p:ppp5c|PPP5C]]|0.414|
|[[:human genes:o:orc5|ORC5]]|0.414|
|[[:human genes:v:vhl|VHL]]|0.414|
|[[:human genes:d:dcp2|DCP2]]|0.414|
|[[:human genes:o:oip5|OIP5]]|0.413|
|[[:human genes:p:phb|PHB]]|0.413|
|[[:human genes:t:tars2|TARS2]]|0.413|
|[[:human genes:z:zbtb11|ZBTB11]]|0.413|
|[[:human genes:m:mlst8|MLST8]]|0.412|
|[[:human genes:p:pik3r4|PIK3R4]]|0.412|
|[[:human genes:z:znhit1|ZNHIT1]]|0.411|
|[[:human genes:z:znf608|ZNF608]]|0.411|
|[[:human genes:m:mrps9|MRPS9]]|0.411|
|[[:human genes:f:fbxo11|FBXO11]]|0.411|
|[[:human genes:s:snf8|SNF8]]|0.411|
|[[:human genes:f:fgfr1op|FGFR1OP]]|0.41|
|[[:human genes:z:zzz3|ZZZ3]]|0.41|
|[[:human genes:b:bub3|BUB3]]|0.41|
|[[:human genes:s:smg9|SMG9]]|0.409|
|[[:human genes:t:timm44|TIMM44]]|0.408|
|[[:human genes:p:pgk1|PGK1]]|0.406|
|[[:human genes:u:ubqln1|UBQLN1]]|0.406|
|[[:human genes:p:pdpk1|PDPK1]]|0.405|
|[[:human genes:n:nbn|NBN]]|0.405|
|[[:human genes:n:nupl2|NUPL2]]|0.404|
|[[:human genes:d:dnajb11|DNAJB11]]|0.404|
|[[:human genes:n:nup50|NUP50]]|0.403|
|[[:human genes:t:timm8b|TIMM8B]]|0.402|
|[[:human genes:c:cops8|COPS8]]|0.401|
|[[:human genes:w:wsb1|WSB1]]|0.401|
|[[:human genes:d:dpm3|DPM3]]|0.4|
|[[:human genes:c:chordc1|CHORDC1]]|0.4|
|[[:human genes:r:rbfa|RBFA]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 24/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|2/28|
|blood|1/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|0/21|
|liver|3/20|
|lung|3/75|
|lymphocyte|1/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|2/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1463
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.09 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PMM2 Expression in NALM6 Cells: 6.09'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>