POLDIP2 [The Human Chemical-Genetic Interaction Map Project]

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======= POLDIP2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: POLDIP2
  * **<color #00a2e8>Official Name</color>**: DNA polymerase delta interacting protein 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=26073|26073]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y2S7|Q9Y2S7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=POLDIP2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20POLDIP2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611519|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mitochondrion morphogenesis|
|negative regulation of macroautophagy|
|mitochondrial nucleoid|
|negative regulation of autophagy|
|positive regulation of mitotic cell cycle|
|regulation of macroautophagy|
|negative regulation of cellular catabolic process|
|negative regulation of catabolic process|
|regulation of autophagy|
|positive regulation of cell cycle|
|mitochondrion organization|
|cell part morphogenesis|
|regulation of mitotic cell cycle|
|cellular component morphogenesis|
|regulation of cellular catabolic process|
|regulation of catabolic process|
|regulation of cell cycle|
|mitochondrion|
|DNA binding|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|-1.81|
|[[:results:exp229|Dimethyloxaloylglycine 100μM R05 exp229]]|1.72|
|[[:results:exp189|Temozolomide 200μM R04 exp189]]|1.74|
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|1.78|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|1.99|
|[[:results:exp270|Campthothecin 0.001μM R06 exp270]]|2.05|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:k:kdm6a|KDM6A]]|0.425|
|[[:human genes:r:ring1|RING1]]|0.418|
|[[:human genes:n:nfatc3|NFATC3]]|0.417|
|[[:human genes:a:anp32a|ANP32A]]|0.417|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: N/A
^Tissue^Fraction Of Cell Lines Where Essential^
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2324
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.54 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='POLDIP2 Expression in NALM6 Cells: 6.54'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>