POLR1A [The Human Chemical-Genetic Interaction Map Project]

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======= POLR1A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: POLR1A
  * **<color #00a2e8>Official Name</color>**: RNA polymerase I subunit A
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=25885|25885]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O95602|O95602]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=POLR1A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20POLR1A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/616404|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is the largest subunit of the RNA polymerase I complex. The encoded protein represents the catalytic subunit of the complex, which transcribes DNA into ribosomal RNA precursors. Defects in this gene are a cause of the Cincinnati type of acrofacial dysostosis. [provided by RefSeq, May 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Forms the polymerase active center together with the second largest subunit. A single stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol I. A bridging helix emanates from RPA1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol I by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition (By similarity). {ECO:0000250|UniProtKB:P10964}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RNA pol Rpb1 3|
|RNA pol Rpb1 1|
|RNA pol Rpb1 5|
|RNA pol Rpb1 2|
|RNA pol Rpb1 4|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of protein localization to nucleolus|
|regulation of protein localization to nucleolus|
|RNA polymerase I complex|
|RNA polymerase I activity|
|transcription elongation from RNA polymerase I promoter|
|negative regulation of protein localization to nucleus|
|termination of RNA polymerase I transcription|
|DNA-directed 5-3 RNA polymerase activity|
|transcription initiation from RNA polymerase I promoter|
|transcription by RNA polymerase I|
|positive regulation of gene expression, epigenetic|
|DNA-templated transcription, termination|
|DNA-templated transcription, elongation|
|negative regulation of cellular protein localization|
|regulation of protein localization to nucleus|
|DNA-templated transcription, initiation|
|regulation of gene expression, epigenetic|
|chromatin binding|
|regulation of cellular protein localization|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|zinc ion binding|
|regulation of cellular localization|
|regulation of protein localization|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|organic cyclic compound biosynthetic process|
|DNA binding|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|positive regulation of gene expression|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp515|PU-H71 1μM R08 exp515]]|-2.36|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|-2.16|
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|1.7|
|[[:results:exp310|2-Methoxyestradiol 0.55μM R07 exp310]]|1.73|
|[[:results:exp51|Nifuroxazide 1μM R01 exp51]]|1.77|
|[[:results:exp319|ABT-702 5μM plus Dimethyloxaloylglycine 11μM R07 exp319]]|1.79|
|[[:results:exp249|Vinorelbine 0.001μM R05 exp249]]|1.82|
|[[:results:exp183|IU1-C 25μM R04 exp183]]|1.84|
|[[:results:exp426|FBS-Wisent 0.1 R07 exp426]]|1.88|
|[[:results:exp40|2-Methoxyestradiol 0.2μM R01 exp40]]|2.01|
|[[:results:exp232|Epothilone-D 0.004 to 0.006μM on day4 R05 exp232]]|2.01|
|[[:results:exp61|YM155 0.0002μM R01 exp61]]|2.05|
|[[:results:exp222|Betulinic acid 10 to 15μM on day4 R05 exp222]]|2.09|
|[[:results:exp533|TNF-alpha 44ng/ml R08 exp533]]|2.11|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:chd4|CHD4]]|0.52|
|[[:human genes:o:orc1|ORC1]]|0.492|
|[[:human genes:c:cln6|CLN6]]|0.481|
|[[:human genes:v:vasn|VASN]]|0.48|
|[[:human genes:s:supt6h|SUPT6H]]|0.479|
|[[:human genes:m:mt1e|MT1E]]|0.479|
|[[:human genes:t:tceb3c|TCEB3C]]|0.473|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.472|
|[[:human genes:p:psmb4|PSMB4]]|0.472|
|[[:human genes:u:utp3|UTP3]]|0.47|
|[[:human genes:p:psmb2|PSMB2]]|0.467|
|[[:human genes:p:pan2|PAN2]]|0.467|
|[[:human genes:t:ticrr|TICRR]]|0.464|
|[[:human genes:t:tyms|TYMS]]|0.462|
|[[:human genes:p:psmc6|PSMC6]]|0.461|
|[[:human genes:p:pola2|POLA2]]|0.461|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.46|
|[[:human genes:r:rpl35|RPL35]]|0.457|
|[[:human genes:c:copb1|COPB1]]|0.457|
|[[:human genes:m:mki67ip|MKI67IP]]|0.455|
|[[:human genes:a:aatf|AATF]]|0.453|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.453|
|[[:human genes:k:kctd17|KCTD17]]|0.452|
|[[:human genes:p:psmb1|PSMB1]]|0.452|
|[[:human genes:p:psma6|PSMA6]]|0.45|
|[[:human genes:v:vps54|VPS54]]|0.449|
|[[:human genes:s:slc4a1|SLC4A1]]|0.448|
|[[:human genes:r:rps7|RPS7]]|0.447|
|[[:human genes:p:polr2j3|POLR2J3]]|0.447|
|[[:human genes:a:akirin2|AKIRIN2]]|0.445|
|[[:human genes:d:dtl|DTL]]|0.445|
|[[:human genes:c:cbwd3|CBWD3]]|0.443|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.442|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.442|
|[[:human genes:c:chmp2a|CHMP2A]]|0.442|
|[[:human genes:c:col2a1|COL2A1]]|0.44|
|[[:human genes:n:nol10|NOL10]]|0.439|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.439|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.438|
|[[:human genes:o:orc6|ORC6]]|0.436|
|[[:human genes:c:c14orf93|C14orf93]]|0.436|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.436|
|[[:human genes:h:hist1h2be|HIST1H2BE]]|0.435|
|[[:human genes:o:ogfr|OGFR]]|0.435|
|[[:human genes:v:vps51|VPS51]]|0.435|
|[[:human genes:s:supt5h|SUPT5H]]|0.434|
|[[:human genes:k:kpnb1|KPNB1]]|0.434|
|[[:human genes:r:rbm39|RBM39]]|0.434|
|[[:human genes:c:cdc73|CDC73]]|0.434|
|[[:human genes:p:psmc2|PSMC2]]|0.433|
|[[:human genes:r:rfc1|RFC1]]|0.432|
|[[:human genes:s:sf3a3|SF3A3]]|0.431|
|[[:human genes:t:traip|TRAIP]]|0.431|
|[[:human genes:p:psma7|PSMA7]]|0.431|
|[[:human genes:e:exosc1|EXOSC1]]|0.43|
|[[:human genes:r:rpl6|RPL6]]|0.429|
|[[:human genes:a:arcn1|ARCN1]]|0.428|
|[[:human genes:n:nupl1|NUPL1]]|0.427|
|[[:human genes:c:cbwd6|CBWD6]]|0.427|
|[[:human genes:c:chmp4b|CHMP4B]]|0.427|
|[[:human genes:i:ik|IK]]|0.425|
|[[:human genes:o:osbp|OSBP]]|0.425|
|[[:human genes:a:aamp|AAMP]]|0.425|
|[[:human genes:r:rps2|RPS2]]|0.424|
|[[:human genes:t:tuba8|TUBA8]]|0.424|
|[[:human genes:c:cactin|CACTIN]]|0.424|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.424|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.424|
|[[:human genes:g:gid4|GID4]]|0.424|
|[[:human genes:u:usp35|USP35]]|0.424|
|[[:human genes:a:atp6v0c|ATP6V0C]]|0.423|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.423|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.423|
|[[:human genes:i:ints5|INTS5]]|0.422|
|[[:human genes:p:psmd14|PSMD14]]|0.42|
|[[:human genes:c:copg1|COPG1]]|0.418|
|[[:human genes:p:prim1|PRIM1]]|0.418|
|[[:human genes:t:tfip11|TFIP11]]|0.416|
|[[:human genes:t:twistnb|TWISTNB]]|0.416|
|[[:human genes:m:med17|MED17]]|0.415|
|[[:human genes:r:rrp7a|RRP7A]]|0.415|
|[[:human genes:v:vps28|VPS28]]|0.414|
|[[:human genes:r:rrn3|RRN3]]|0.414|
|[[:human genes:z:znf830|ZNF830]]|0.412|
|[[:human genes:e:exosc8|EXOSC8]]|0.411|
|[[:human genes:c:cbwd5|CBWD5]]|0.411|
|[[:human genes:c:cog4|COG4]]|0.411|
|[[:human genes:c:clasp1|CLASP1]]|0.409|
|[[:human genes:c:cep192|CEP192]]|0.408|
|[[:human genes:t:tp53tg3b|TP53TG3B]]|0.408|
|[[:human genes:t:tp53tg3c|TP53TG3C]]|0.407|
|[[:human genes:t:tp53tg3|TP53TG3]]|0.407|
|[[:human genes:m:mfsd12|MFSD12]]|0.407|
|[[:human genes:t:tspy2|TSPY2]]|0.407|
|[[:human genes:p:psmb3|PSMB3]]|0.405|
|[[:human genes:d:ddtl|DDTL]]|0.404|
|[[:human genes:i:itga2b|ITGA2B]]|0.402|
|[[:human genes:c:cdca3|CDCA3]]|0.402|
|[[:human genes:r:rpa2|RPA2]]|0.401|
|[[:human genes:m:myo18a|MYO18A]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 723/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|28/28|
|bone|24/25|
|breast|33/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|16/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|15/15|
|kidney|21/21|
|liver|20/20|
|lung|75/75|
|lymphocyte|14/14|
|ovary|26/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|23/24|
|soft tissue|7/7|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|29/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 157
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.23 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='POLR1A Expression in NALM6 Cells: 8.23'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>