POLR1B [The Human Chemical-Genetic Interaction Map Project]

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======= POLR1B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: POLR1B
  * **<color #00a2e8>Official Name</color>**: RNA polymerase I subunit B
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=84172|84172]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H9Y6|Q9H9Y6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=POLR1B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20POLR1B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602000|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RNA pol Rpb2 6|
|RNA pol Rpb2 7|
|RNA pol Rpb2 3|
|RNA pol Rpb2 2|
|RNA pol Rpb2 1|
|RNA pol Rpa2 4|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|nucleologenesis|
|ribonucleoside binding|
|nucleolus organization|
|RNA polymerase I complex|
|RNA polymerase I activity|
|rRNA transcription|
|transcription elongation from RNA polymerase I promoter|
|termination of RNA polymerase I transcription|
|DNA-directed 5-3 RNA polymerase activity|
|transcription initiation from RNA polymerase I promoter|
|embryo implantation|
|transcription by RNA polymerase I|
|positive regulation of gene expression, epigenetic|
|DNA-templated transcription, termination|
|DNA-templated transcription, elongation|
|ncRNA transcription|
|nucleus organization|
|female pregnancy|
|multi-multicellular organism process|
|DNA-templated transcription, initiation|
|regulation of gene expression, epigenetic|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|nucleolus|
|multi-organism reproductive process|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|organic cyclic compound biosynthetic process|
|reproductive process|
|reproduction|
|DNA binding|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|positive regulation of gene expression|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp355|Dinaciclib 0.007μM R07 exp355]]|-2.43|
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|-2.33|
|[[:results:exp446|4-Nitroquinoline-1-oxide 0.5μM R08 exp446]]|-2.32|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|-2.28|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|-2.24|
|[[:results:exp146|Quinacrine 2.5μM R03 exp146]]|-2.11|
|[[:results:exp256|HMS-I1 10μM R06 exp256]]|-2|
|[[:results:exp539|42°C R08 exp539]]|-1.95|
|[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|-1.9|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|-1.88|
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|-1.8|
|[[:results:exp513|ONC212 0.15μM R08 exp513]]|-1.78|
|[[:results:exp143|Phenformin 20μM R03 exp143]]|1.74|
|[[:results:exp128|GSK591 2.6μM R03 exp128]]|1.81|
|[[:results:exp58|UM131593 0.1μM R01 exp58]]|1.85|
|[[:results:exp490|Hydroxychloroquine 30μM R08 exp490]]|1.91|
|[[:results:exp261|ABT-702 5μM R06 exp261]]|2.03|
|[[:results:exp41|BI-2536 0.001μM R01 exp41]]|2.15|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.502|
|[[:human genes:r:rpl8|RPL8]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 568/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|20/28|
|blood|19/28|
|bone|16/25|
|breast|22/33|
|central nervous system|51/56|
|cervix|4/4|
|colorectal|13/17|
|esophagus|12/13|
|fibroblast|1/1|
|gastric|14/15|
|kidney|15/21|
|liver|17/20|
|lung|60/75|
|lymphocyte|11/14|
|ovary|20/26|
|pancreas|17/24|
|peripheral nervous system|13/16|
|plasma cell|8/15|
|prostate|0/1|
|skin|19/24|
|soft tissue|5/7|
|thyroid|2/2|
|upper aerodigestive|20/22|
|urinary tract|26/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 115
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.9 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='POLR1B Expression in NALM6 Cells: 6.9'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>