POLR2L [The Human Chemical-Genetic Interaction Map Project]

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======= POLR2L =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: POLR2L
  * **<color #00a2e8>Official Name</color>**: RNA polymerase II subunit L
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5441|5441]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P62875|P62875]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=POLR2L&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20POLR2L|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601189|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2L/RBP10 is part of the core element with the central large cleft (By similarity). {ECO:0000250, ECO:0000269|PubMed:9852112}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RNA pol N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|tRNA transcription by RNA polymerase III|
|tRNA transcription|
|RNA polymerase II activity|
|RNA polymerase I activity|
|RNA polymerase I complex|
|RNA polymerase II, core complex|
|RNA polymerase III activity|
|RNA polymerase III complex|
|transcription elongation from RNA polymerase I promoter|
|termination of RNA polymerase I transcription|
|regulation of transcription by RNA polymerase I|
|DNA-directed 5-3 RNA polymerase activity|
|7-methylguanosine mRNA capping|
|RNA capping|
|7-methylguanosine RNA capping|
|transcription initiation from RNA polymerase I promoter|
|transcription by RNA polymerase I|
|positive regulation of viral transcription|
|transcription by RNA polymerase III|
|positive regulation of gene expression, epigenetic|
|regulation of viral transcription|
|somatic stem cell population maintenance|
|snRNA transcription by RNA polymerase II|
|snRNA transcription|
|DNA-templated transcription, termination|
|transcription-coupled nucleotide-excision repair|
|transcription elongation from RNA polymerase II promoter|
|positive regulation of type I interferon production|
|fibroblast growth factor receptor signaling pathway|
|regulation of gene silencing by miRNA|
|regulation of gene silencing by RNA|
|regulation of posttranscriptional gene silencing|
|DNA-templated transcription, elongation|
|ncRNA transcription|
|positive regulation of viral process|
|cellular response to fibroblast growth factor stimulus|
|nucleotide-excision repair|
|response to fibroblast growth factor|
|regulation of type I interferon production|
|regulation of gene silencing|
|stem cell population maintenance|
|maintenance of cell number|
|transcription initiation from RNA polymerase II promoter|
|regulation of viral process|
|DNA-templated transcription, initiation|
|regulation of symbiosis, encompassing mutualism through parasitism|
|regulation of gene expression, epigenetic|
|RNA splicing, via transesterification reactions with bulged adenosine as nucleophile|
|mRNA splicing, via spliceosome|
|RNA splicing, via transesterification reactions|
|RNA splicing|
|positive regulation of cytokine production|
|mRNA processing|
|transcription by RNA polymerase II|
|cellular response to growth factor stimulus|
|DNA repair|
|positive regulation of multi-organism process|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|response to growth factor|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|mRNA metabolic process|
|regulation of cytokine production|
|enzyme linked receptor protein signaling pathway|
|DNA metabolic process|
|regulation of multi-organism process|
|cellular response to DNA damage stimulus|
|zinc ion binding|
|RNA processing|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|cellular response to endogenous stimulus|
|organic cyclic compound biosynthetic process|
|DNA binding|
|response to endogenous stimulus|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular response to stress|
|cellular macromolecule biosynthetic process|
|positive regulation of multicellular organismal process|
|macromolecule biosynthetic process|
|positive regulation of gene expression|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp443|SNS-032 15μM R08 exp443]]|-3.54|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|-3.45|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|-2.34|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|-2.28|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|-2.26|
|[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|-2.07|
|[[:results:exp532|TIC10 10μM R08 exp532]]|-2|
|[[:results:exp401|SNS-032 25μM R07 exp401]]|-1.99|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|-1.91|
|[[:results:exp433|LJH685 50μM R08 exp433]]|-1.9|
|[[:results:exp111|R-DABN 8μM R03 exp111]]|-1.77|
|[[:results:exp159|Docetaxel 0.001 to 0.002μM on day4 R04 exp159]]|1.76|
|[[:results:exp176|Apcin 50 to 100μM on day4 R04 exp176]]|1.85|
|[[:results:exp37|Wortmannin 0.5μM R00 exp37]]|1.87|
|[[:results:exp20|Etoposide 10μM R00 exp20]]|2.01|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|2.03|
|[[:results:exp245|UM0011500 5μM R05 exp245]]|2.1|
|[[:results:exp164|Q15 1 to 2μM on day4 R04 exp164]]|2.27|
|[[:results:exp537|WNT3A 44ng/ml R08 exp537]]|2.63|
|[[:results:exp341|BRD2 inhibitor II 20μM R07 exp341]]|2.96|
|[[:results:exp238|Parthenolide 2.5μM R05 exp238]]|3.42|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:psma6|PSMA6]]|0.482|
|[[:human genes:p:polr2j3|POLR2J3]]|0.478|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.471|
|[[:human genes:k:kctd17|KCTD17]]|0.47|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.464|
|[[:human genes:a:acsf2|ACSF2]]|0.455|
|[[:human genes:p:psma7|PSMA7]]|0.452|
|[[:human genes:r:rrp7a|RRP7A]]|0.452|
|[[:human genes:a:aqr|AQR]]|0.446|
|[[:human genes:p:psmb2|PSMB2]]|0.437|
|[[:human genes:c:chd4|CHD4]]|0.435|
|[[:human genes:r:rps12|RPS12]]|0.434|
|[[:human genes:n:napa|NAPA]]|0.419|
|[[:human genes:p:pde4dip|PDE4DIP]]|0.418|
|[[:human genes:s:sh3bp1|SH3BP1]]|0.416|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.416|
|[[:human genes:c:cox7a2l|COX7A2L]]|0.414|
|[[:human genes:n:nup160|NUP160]]|0.412|
|[[:human genes:r:rpl35|RPL35]]|0.411|
|[[:human genes:c:cactin|CACTIN]]|0.411|
|[[:human genes:t:tfip11|TFIP11]]|0.409|
|[[:human genes:c:cbwd6|CBWD6]]|0.408|
|[[:human genes:e:exosc9|EXOSC9]]|0.407|
|[[:human genes:n:nupl1|NUPL1]]|0.406|
|[[:human genes:s:slc38a7|SLC38A7]]|0.406|
|[[:human genes:t:tp53tg3d|TP53TG3D]]|0.404|
|[[:human genes:n:narfl|NARFL]]|0.403|
|[[:human genes:c:cbwd3|CBWD3]]|0.4|
|[[:human genes:n:nfatc4|NFATC4]]|0.4|
|[[:human genes:p:pole|POLE]]|0.4|
|[[:human genes:m:mt1e|MT1E]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 725/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|27/28|
|bone|25/25|
|breast|33/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|15/15|
|kidney|21/21|
|liver|20/20|
|lung|75/75|
|lymphocyte|14/14|
|ovary|26/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|7/7|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|29/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 784
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.65 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='POLR2L Expression in NALM6 Cells: 5.65'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>