POU1F1 [The Human Chemical-Genetic Interaction Map Project]

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======= POU1F1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: POU1F1
  * **<color #00a2e8>Official Name</color>**: POU class 1 homeobox 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5449|5449]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P28069|P28069]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=POU1F1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20POU1F1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/173110|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the POU family of transcription factors that regulate mammalian development. The protein regulates expression of several genes involved in pituitary development and hormone expression. Mutations in this genes result in combined pituitary hormone deficiency. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Transcription factor involved in the specification of the lactotrope, somatotrope, and thyrotrope phenotypes in the developing anterior pituitary. Specifically binds to the consensus sequence 5'-TAAAT-3'. Activates growth hormone and prolactin genes (PubMed:22010633, PubMed:26612202). {ECO:0000269|PubMed:22010633, ECO:0000269|PubMed:26612202}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pou|
|Homeobox|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|somatotropin secreting cell development|
|somatotropin secreting cell differentiation|
|positive regulation of inositol trisphosphate biosynthetic process|
|regulation of inositol trisphosphate biosynthetic process|
|adenohypophysis development|
|positive regulation of inositol phosphate biosynthetic process|
|regulation of inositol phosphate biosynthetic process|
|determination of adult lifespan|
|regulation of insulin-like growth factor receptor signaling pathway|
|positive regulation of alcohol biosynthetic process|
|positive regulation of multicellular organism growth|
|multicellular organism aging|
|pituitary gland development|
|RNA polymerase II activating transcription factor binding|
|positive regulation of cellular carbohydrate metabolic process|
|RNA polymerase II transcription factor binding|
|regulation of multicellular organism growth|
|regulation of alcohol biosynthetic process|
|diencephalon development|
|positive regulation of carbohydrate metabolic process|
|cell fate specification|
|regulation of carbohydrate biosynthetic process|
|B cell differentiation|
|chromatin|
|endocrine system development|
|positive regulation of small molecule metabolic process|
|regulation of cellular carbohydrate metabolic process|
|B cell activation|
|positive regulation of developmental growth|
|regulation of carbohydrate metabolic process|
|transcription factor complex|
|lymphocyte differentiation|
|cell fate commitment|
|positive regulation of growth|
|aging|
|regulation of developmental growth|
|leukocyte differentiation|
|lymphocyte activation|
|forebrain development|
|chromatin binding|
|gland development|
|regulation of small molecule metabolic process|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|transcription by RNA polymerase II|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|hemopoiesis|
|hematopoietic or lymphoid organ development|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|immune system development|
|RNA biosynthetic process|
|regulation of growth|
|DNA-binding transcription factor activity|
|negative regulation of cell population proliferation|
|brain development|
|head development|
|negative regulation of transcription by RNA polymerase II|
|positive regulation of cell population proliferation|
|leukocyte activation|
|central nervous system development|
|cell activation|
|nucleobase-containing compound biosynthetic process|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|negative regulation of transcription, DNA-templated|
|positive regulation of transcription by RNA polymerase II|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|organic cyclic compound biosynthetic process|
|negative regulation of RNA metabolic process|
|positive regulation of developmental process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of cell population proliferation|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|cell development|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|macromolecule biosynthetic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp230|Epigallocatechin gallate 20μM R05 exp230]]|1.71|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14363
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='POU1F1 Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>