POU3F3 [The Human Chemical-Genetic Interaction Map Project]

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======= POU3F3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: POU3F3
  * **<color #00a2e8>Official Name</color>**: POU class 3 homeobox 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5455|5455]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P20264|P20264]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=POU3F3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20POU3F3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602480|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Transcription factor that acts synergistically with SOX11 and SOX4. Plays a role in neuronal development. Is implicated in an enhancer activity at the embryonic met- mesencephalic junction; the enhancer element contains the octamer motif (5'-ATTTGCAT-3') (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Homeobox|
|Pou|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|metanephric juxtaglomerular apparatus development|
|macula densa development|
|metanephric DCT cell differentiation|
|DCT cell differentiation|
|metanephric macula densa development|
|juxtaglomerular apparatus development|
|metanephric thick ascending limb development|
|thick ascending limb development|
|metanephric ascending thin limb development|
|ascending thin limb development|
|distal convoluted tubule development|
|metanephric distal convoluted tubule development|
|metanephric loop of Henle development|
|forebrain ventricular zone progenitor cell division|
|metanephric distal tubule development|
|loop of Henle development|
|distal tubule development|
|metanephric nephron tubule development|
|HMG box domain binding|
|cell differentiation involved in metanephros development|
|metanephric nephron epithelium development|
|metanephric tubule development|
|metanephric epithelium development|
|cell proliferation in forebrain|
|cerebral cortex radially oriented cell migration|
|excretion|
|cell differentiation involved in kidney development|
|cerebral cortex cell migration|
|telencephalon cell migration|
|forebrain cell migration|
|neural precursor cell proliferation|
|nephron tubule development|
|renal tubule development|
|metanephros development|
|nephron epithelium development|
|cerebral cortex development|
|nephron development|
|kidney epithelium development|
|pallium development|
|telencephalon development|
|kidney development|
|renal system development|
|urogenital system development|
|forebrain development|
|sequence-specific DNA binding|
|cell division|
|cell population proliferation|
|DNA-binding transcription factor activity|
|brain development|
|head development|
|tube development|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|positive regulation of cell population proliferation|
|cell migration|
|central nervous system development|
|negative regulation of cell death|
|localization of cell|
|cell motility|
|chemical homeostasis|
|epithelium development|
|negative regulation of transcription, DNA-templated|
|positive regulation of transcription by RNA polymerase II|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|locomotion|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|positive regulation of transcription, DNA-templated|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|movement of cell or subcellular component|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of programmed cell death|
|regulation of cell population proliferation|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|homeostatic process|
|regulation of cell death|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|tissue development|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|system process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10250
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.4 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='POU3F3 Expression in NALM6 Cells: 3.4'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>