PPAT [The Human Chemical-Genetic Interaction Map Project]

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======= PPAT =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PPAT
  * **<color #00a2e8>Official Name</color>**: phosphoribosyl pyrophosphate amidotransferase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5471|5471]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q06203|Q06203]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PPAT&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PPAT|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/172450|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pribosyltran|
|GATase 2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|amidophosphoribosyltransferase activity|
|glutamine catabolic process|
|de novo IMP biosynthetic process|
|IMP biosynthetic process|
|purine nucleobase biosynthetic process|
|IMP metabolic process|
|purine ribonucleoside monophosphate biosynthetic process|
|purine nucleoside monophosphate biosynthetic process|
|nucleobase biosynthetic process|
|purine nucleobase metabolic process|
|glutamine metabolic process|
|glutamine family amino acid catabolic process|
|ribonucleoside monophosphate biosynthetic process|
|purine ribonucleoside monophosphate metabolic process|
|purine nucleoside monophosphate metabolic process|
|4 iron, 4 sulfur cluster binding|
|nucleobase metabolic process|
|nucleoside monophosphate biosynthetic process|
|lactation|
|pigment biosynthetic process|
|ribonucleoside monophosphate metabolic process|
|maternal process involved in female pregnancy|
|pigment metabolic process|
|glutamine family amino acid metabolic process|
|animal organ regeneration|
|body fluid secretion|
|nucleoside monophosphate metabolic process|
|protein homotetramerization|
|alpha-amino acid catabolic process|
|nucleoside metabolic process|
|G1/S transition of mitotic cell cycle|
|cell cycle G1/S phase transition|
|cellular amino acid catabolic process|
|mammary gland development|
|glycosyl compound metabolic process|
|purine ribonucleotide biosynthetic process|
|protein tetramerization|
|regeneration|
|purine nucleotide biosynthetic process|
|ribonucleotide biosynthetic process|
|cellular response to insulin stimulus|
|ribose phosphate biosynthetic process|
|purine-containing compound biosynthetic process|
|female pregnancy|
|alpha-amino acid metabolic process|
|multi-multicellular organism process|
|response to insulin|
|nucleotide biosynthetic process|
|nucleoside phosphate biosynthetic process|
|cellular response to peptide hormone stimulus|
|organic acid catabolic process|
|carboxylic acid catabolic process|
|kidney development|
|mitotic cell cycle phase transition|
|cell cycle phase transition|
|renal system development|
|cellular amino acid metabolic process|
|purine ribonucleotide metabolic process|
|urogenital system development|
|cellular response to peptide|
|ribonucleotide metabolic process|
|purine nucleotide metabolic process|
|ribose phosphate metabolic process|
|protein homooligomerization|
|purine-containing compound metabolic process|
|response to peptide hormone|
|cellular response to drug|
|gland development|
|small molecule catabolic process|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|response to peptide|
|regulation of body fluid levels|
|protein complex oligomerization|
|organophosphate biosynthetic process|
|nucleobase-containing small molecule metabolic process|
|mitotic cell cycle process|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|carbohydrate derivative biosynthetic process|
|cellular response to nitrogen compound|
|mitotic cell cycle|
|multicellular organismal reproductive process|
|multicellular organism reproduction|
|organophosphate metabolic process|
|response to hormone|
|carboxylic acid metabolic process|
|multi-organism reproductive process|
|cell cycle process|
|response to organonitrogen compound|
|oxoacid metabolic process|
|response to drug|
|organic acid metabolic process|
|carbohydrate derivative metabolic process|
|cellular response to oxygen-containing compound|
|organonitrogen compound catabolic process|
|response to nitrogen compound|
|nucleobase-containing compound biosynthetic process|
|secretion|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|cellular response to endogenous stimulus|
|organic cyclic compound biosynthetic process|
|cell cycle|
|organonitrogen compound biosynthetic process|
|reproductive process|
|reproduction|
|response to endogenous stimulus|
|response to oxygen-containing compound|
|protein-containing complex assembly|
|cellular nitrogen compound biosynthetic process|
|small molecule metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 72/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|3/28|
|blood|9/28|
|bone|1/26|
|breast|5/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|2/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|3/21|
|liver|0/20|
|lung|12/75|
|lymphocyte|1/16|
|ovary|0/26|
|pancreas|5/24|
|peripheral nervous system|1/16|
|plasma cell|4/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|5/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1181
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.67 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PPAT Expression in NALM6 Cells: 6.67'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>